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PMID:16773041
| Citation |
Helleboid-Chapman, A, Helleboid, S, Jakel, H, Timmerman, C, Sergheraert, C, Pattou, F, Fruchart-Najib, J and Fruchart, JC (2006) Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells. Cell Res. 16:661-70 |
|---|---|
| Abstract |
Liver X receptors (LXRs) are members of the nuclear receptor superfamily, which have been implicated in lipid homeostasis and more recently in glucose metabolism. Here, we show that glucose does not change LXRalpha protein level, but affects its localization in pancreatic beta-cells. LXRalpha is found in the nucleus at 8 mM glucose and in the cytoplasm at 4.2 mM. Addition of glucose translocates LXRalpha from the cytoplasm into the nucleus. Moreover, after the activation of LXR by its synthetic non-steroidal agonist (T0901317), insulin secretion and glucose uptake are increased at 8 mM and decreased at 4.2 mM glucose in a dose-dependent manner. Furthermore, at low glucose condition, okadaic acid reversed LXRalpha effect on insulin secretion, suggesting the involvement of glucose signaling through a phosphorylation-dependent mechanism. |
| Links |
PubMed Online version:10.1038/sj.cr.7310069 |
| Keywords |
Animals; Antigens, CD95/metabolism; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Enzyme Inhibitors/metabolism; Glucose/metabolism; Hydrocarbons, Fluorinated; Insulin/metabolism; Insulin-Secreting Cells/cytology; Insulin-Secreting Cells/metabolism; Okadaic Acid/metabolism; Orphan Nuclear Receptors; Peptides/genetics; Peptides/metabolism; Rats; Receptors, Cytoplasmic and Nuclear/genetics; Receptors, Cytoplasmic and Nuclear/metabolism; Sterol Regulatory Element Binding Protein 1/metabolism; Sulfonamides/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
See also
References
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