RAT:NMDZ1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Grin1 (synonyms: Nmdar1)
Protein Name(s)	Glutamate receptor ionotropic, NMDA 1 GluN1 Glutamate [NMDA] receptor subunit zeta-1 N-methyl-D-aspartate receptor subunit NR1 NMD-R1
External Links
UniProt	P35439
EMBL	X63255 AY157515 U08261 U08262 U08263 U08264 U08265 U08267 U08268 S39217 S39218 S39219 S39220 S39221 X65227
PIR	JN0336 JN0337 JN0338 JN0339 JN0340 JN0341 JN0342 S19710
RefSeq	NP_001257531.1 NP_001257532.1 NP_001257534.1 NP_001257537.1 NP_001257539.1 NP_001274352.1 NP_058706.1
UniGene	Rn.9840
PDB	1PB7 1PB8 1PB9 1PBQ 1Y1M 1Y1Z 1Y20 2A5T 3Q41 4KCC 4KFQ 4NF4 4NF5 4NF6 4NF8 4PE5
PDBsum	1PB7 1PB8 1PB9 1PBQ 1Y1M 1Y1Z 1Y20 2A5T 3Q41 4KCC 4KFQ 4NF4 4NF5 4NF6 4NF8 4PE5
ProteinModelPortal	P35439
SMR	P35439
BioGrid	246573
DIP	DIP-674N
IntAct	P35439
MINT	MINT-101336
BindingDB	P35439
ChEMBL	CHEMBL2096911
GuidetoPHARMACOLOGY	455
PhosphoSite	P35439
PaxDb	P35439
PRIDE	P35439
Ensembl	ENSRNOT00000037725 ENSRNOT00000044246 ENSRNOT00000049297
GeneID	24408
KEGG	rno:24408
UCSC	RGD:2736
CTD	2902
RGD	2736
eggNOG	NOG282132
GeneTree	ENSGT00760000119186
HOGENOM	HOG000231491
HOVERGEN	HBG052638
InParanoid	P35439
KO	K05208
OMA	TMSDGTC
OrthoDB	EOG79GT5V
PhylomeDB	P35439
TreeFam	TF351405
Reactome	REACT_196389 REACT_196392 REACT_241561 REACT_258198
EvolutionaryTrace	P35439
NextBio	603223
PRO	PR:P35439
Proteomes	UP000002494
ExpressionAtlas	P35439
Genevestigator	P35439
GO	GO:0030054 GO:0009986 GO:0032590 GO:0043197 GO:0005783 GO:0060076 GO:0017146 GO:0097481 GO:0014069 GO:0045211 GO:0045202 GO:0043083 GO:0008021 GO:0043195 GO:0005262 GO:0005509 GO:0019899 GO:0005234 GO:0016595 GO:0035254 GO:0016594 GO:0004970 GO:0004972 GO:0042165 GO:0046983 GO:0046982 GO:0005102 GO:0022843 GO:0008344 GO:0006874 GO:0071287 GO:0021987 GO:0001661 GO:0034220 GO:0035235 GO:0007611 GO:0007616 GO:0060179 GO:0043524 GO:0008355 GO:0021586 GO:0043065 GO:0010942 GO:2000463 GO:0045944 GO:0060134 GO:0018964 GO:0051262 GO:0050770 GO:0048814 GO:0034765 GO:0048169 GO:0043576 GO:0051963 GO:0007585 GO:0014075 GO:0001975 GO:0051592 GO:0045471 GO:0060992 GO:0043278 GO:0014070 GO:0048511 GO:0019233 GO:0035176 GO:0001967 GO:0035249 GO:0008542
InterPro	IPR001828 IPR018882 IPR019594 IPR001508 IPR001320 IPR028082
Pfam	PF01094 PF10562 PF00060
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045202	synapse	PMID:19450252^[1]	ECO:0000314			C		Figure 6D showed that patching of Nlgn1 clustered NR1 at synaptic location.	complete
enables	GO:0001540	amyloid-beta binding	PMID:17308309^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0097060) occurs_in:(UBERON:0001890) positively_regulates:(GO:0060402)\|occurs_in(GO:0097060) occurs_in:(UBERON:0001890) positively_regulates:(GO:1903409)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17526495^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17526495^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:24876489^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:24876489^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:24876489^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:24876489^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:24876489^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	PMID:17526495^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q00960	P	occurs_in:(CL:0002608) regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:17308309^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002608) positively_regulates:(GO:1903409)	Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	PMID:17308309^[2]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	C	part_of:(UBERON:0001890)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:17308309^[2]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F	occurs_in:(GO:0097060) occurs_in:(UBERON:0001890) positively_regulates:(GO:0060402)\|occurs_in(GO:0097060) occurs_in:(UBERON:0001890) positively_regulates:(GO:1903409)	Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	PMID:17308309^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	regulates_o_occurs_in:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:18177891^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:18177891^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:18177891^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:28384476^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:28384476^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:28384476^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:12930820^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:19730411^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	PMID:15620359^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	PMID:8011339^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:8011339^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902952	positive regulation of dendritic spine maintenance	PMID:17360908^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1120,UniProtKB:P05067:VAR_000023	P	regulates_o_occurs_in:(CL:1001571)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:12160751^[12]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	PMID:12160751^[12]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(GO:0098978) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	PMID:19666514^[13]	ECO:0006063	over expression analysis evidence used in manual assertion		F	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	PMID:19666514^[13]	ECO:0006054	pharmacological assay evidence used in manual assertion		F	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
enables	GO:0099507	ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	PMID:19666514^[13]	ECO:0006013	patch-clamp recording evidence used in manual assertion		F	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:23159309^[14]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098686)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:19666514^[13]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098688)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12160751^[12]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12160751^[12]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	PMID:19666514^[13]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	PMID:23159309^[14]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900149	positive regulation of Schwann cell migration	PMID:26656067^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071287	cellular response to manganese ion	PMID:19643132^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060992	response to fungicide	PMID:19591855^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	PMID:19761817^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:22493736^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:22493736^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21544205^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:25526735^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044307	dendritic branch	PMID:10618500^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:17207780^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:19666514^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	PMID:17207780^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:10618500^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042165	neurotransmitter binding	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	PMID:19298817^[25]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2737 RGD:2738	F		Seeded From UniProt	complete
involved_in	GO:0035235	ionotropic glutamate receptor signaling pathway	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0022843	voltage-gated cation channel activity	PMID:17050728^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	PMID:15102920^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15069201^[28]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620556	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:22493736^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:17050728^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	PMID:22098737^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014075	response to amine	PMID:19918184^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:19322657^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21314939^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17207780^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:20168047^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12408866^[34]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2518	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:17050728^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:22098737^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	PMID:16477151^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:21873635^[35]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010399 MGI:MGI:95819 PANTHER:PTN001451205 RGD:2736 UniProtKB:Q05586	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[35]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:21873635^[35]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010399 MGI:MGI:95819 PANTHER:PTN001451205 RGD:2736 UniProtKB:Q05586	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:17003121^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15978582^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:15681343^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:7929101^[39]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022843	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1904315	P		Seeded From UniProt	complete
involved_in	GO:0060078	regulation of postsynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1904315	P		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022843	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
involved_in	GO:0099505	regulation of presynaptic membrane potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099507	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:12535174^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:12535174^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12535174^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	PMID:12535174^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-RNO-9618659 Reactome:R-RNO-9617436 Reactome:R-RNO-9617322 Reactome:R-RNO-9614351 Reactome:R-RNO-9614350 Reactome:R-RNO-9614228 Reactome:R-RNO-9612145	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 De Felice, FG et al. (2007) Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282 11590-601 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Karakas, E & Furukawa, H (2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science 344 992-7 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Schmidt, C & Hollmann, M (2008) Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit. J. Mol. Biol. 376 658-70 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Sun, W et al. (2017) Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Neuron 94 58-64.e3 PubMed GONUTS page
↑ Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page
↑ Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page
↑ Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
↑ ^10.0 ^10.1 Kuryatov, A et al. (1994) Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron 12 1291-300 PubMed GONUTS page
↑ Shankar, GM et al. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27 2866-75 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Barria, A & Malinow, R (2002) Subunit-specific NMDA receptor trafficking to synapses. Neuron 35 345-53 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Bidoret, C et al. (2009) Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Proc. Natl. Acad. Sci. U.S.A. 106 14126-31 PubMed GONUTS page
↑ ^14.0 ^14.1 Berg, LK et al. (2013) Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Neuroscience 230 139-50 PubMed GONUTS page
↑ Wei, B et al. (2016) Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Brain Res. 1631 157-64 PubMed GONUTS page
↑ Xu, B et al. (2009) Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology 30 941-9 PubMed GONUTS page
↑ Nakatsu, Y et al. (2009) Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Toxicol. Appl. Pharmacol. 240 292-8 PubMed GONUTS page
↑ Dos-Anjos, S et al. (2009) Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Neuroscience 164 1119-26 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Riou, M et al. (2012) An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors. PLoS ONE 7 e35134 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Ishihama, K et al. (2005) Prenatal development of NMDA receptor composition and function in trigeminal neurons. Arch. Histol. Cytol. 68 321-35 PubMed GONUTS page
↑ Lee, CH & Gouaux, E (2011) Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS ONE 6 e19180 PubMed GONUTS page
↑ Gill, I et al. (2015) Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. J. Cell. Sci. 128 768-80 PubMed GONUTS page
↑ ^23.0 ^23.1 Feliciello, A et al. (1999) Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). FEBS Lett. 464 174-8 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Radley, JJ et al. (2007) Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Brain Res. 1134 87-94 PubMed GONUTS page
↑ Swanwick, CC et al. (2009) NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. FEBS Lett. 583 1226-30 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Qian, A & Johnson, JW (2006) Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. J. Neurosci. 26 10899-910 PubMed GONUTS page
↑ Ning, K et al. (2004) Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J. Neurosci. 24 4052-60 PubMed GONUTS page
↑ Gingrich, JR et al. (2004) Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc. Natl. Acad. Sci. U.S.A. 101 6237-42 PubMed GONUTS page
↑ ^29.0 ^29.1 Talukder, I et al. (2011) GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation. Biophys. J. 101 2389-98 PubMed GONUTS page
↑ Han, LC et al. (2010) The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Eur J Anaesthesiol 27 181-6 PubMed GONUTS page
↑ Bersier, MG & Rodríguez de Lores Arnaiz, G (2009) Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Neurochem. Res. 34 1650-7 PubMed GONUTS page
↑ Gardoni, F et al. (2011) Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. J Neuroinflammation 8 14 PubMed GONUTS page
↑ Fukumori, R et al. (2010) Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. J. Pharmacol. Sci. 112 273-81 PubMed GONUTS page
↑ Lee, FJ et al. (2002) Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 111 219-30 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Schlief, ML et al. (2006) Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proc. Natl. Acad. Sci. U.S.A. 103 14919-24 PubMed GONUTS page
↑ Burkhardt, C et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579 3821-8 PubMed GONUTS page
↑ Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ Chazot, PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269 24403-9 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Lee, PR et al. (2003) Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain. J. Neuroendocrinol. 15 87-92 PubMed GONUTS page

[PMID:19450252-1] Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page

[PMID:17308309-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 De Felice, FG et al. (2007) Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem. 282 11590-601 PubMed GONUTS page

[PMID:17526495-3] 3.0 ^3.1 ^3.2 Wu, HY et al. (2007) Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J. Biol. Chem. 282 20075-87 PubMed GONUTS page

[PMID:24876489-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Karakas, E & Furukawa, H (2014) Crystal structure of a heterotetrameric NMDA receptor ion channel. Science 344 992-7 PubMed GONUTS page

[PMID:18177891-5] 5.0 ^5.1 ^5.2 Schmidt, C & Hollmann, M (2008) Apparent homomeric NR1 currents observed in Xenopus oocytes are caused by an endogenous NR2 subunit. J. Mol. Biol. 376 658-70 PubMed GONUTS page

[PMID:28384476-6] 6.0 ^6.1 ^6.2 Sun, W et al. (2017) Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Neuron 94 58-64.e3 PubMed GONUTS page

[PMID:12930820-7] Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page

[PMID:19730411-8] Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page

[PMID:15620359-9] Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page

[PMID:8011339-10] 10.0 ^10.1 Kuryatov, A et al. (1994) Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. Neuron 12 1291-300 PubMed GONUTS page

[PMID:17360908-11] Shankar, GM et al. (2007) Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27 2866-75 PubMed GONUTS page

[PMID:12160751-12] 12.0 ^12.1 ^12.2 ^12.3 Barria, A & Malinow, R (2002) Subunit-specific NMDA receptor trafficking to synapses. Neuron 35 345-53 PubMed GONUTS page

[PMID:19666514-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Bidoret, C et al. (2009) Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Proc. Natl. Acad. Sci. U.S.A. 106 14126-31 PubMed GONUTS page

[PMID:23159309-14] 14.0 ^14.1 Berg, LK et al. (2013) Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Neuroscience 230 139-50 PubMed GONUTS page

[PMID:26656067-15] Wei, B et al. (2016) Hippocampal NMDAR-Wnt-Catenin signaling disrupted with cognitive deficits in adolescent offspring exposed to prenatal hypoxia. Brain Res. 1631 157-64 PubMed GONUTS page

[PMID:19643132-16] Xu, B et al. (2009) Effect of manganese exposure on intracellular Ca2+ homeostasis and expression of NMDA receptor subunits in primary cultured neurons. Neurotoxicology 30 941-9 PubMed GONUTS page

[PMID:19591855-17] Nakatsu, Y et al. (2009) Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate. Toxicol. Appl. Pharmacol. 240 292-8 PubMed GONUTS page

[PMID:19761817-18] Dos-Anjos, S et al. (2009) Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Neuroscience 164 1119-26 PubMed GONUTS page

[PMID:22493736-19] 19.0 ^19.1 ^19.2 Riou, M et al. (2012) An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors. PLoS ONE 7 e35134 PubMed GONUTS page

[PMID:16477151-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 Ishihama, K et al. (2005) Prenatal development of NMDA receptor composition and function in trigeminal neurons. Arch. Histol. Cytol. 68 321-35 PubMed GONUTS page

[PMID:21544205-21] Lee, CH & Gouaux, E (2011) Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS ONE 6 e19180 PubMed GONUTS page

[PMID:25526735-22] Gill, I et al. (2015) Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo. J. Cell. Sci. 128 768-80 PubMed GONUTS page

[PMID:10618500-23] 23.0 ^23.1 Feliciello, A et al. (1999) Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). FEBS Lett. 464 174-8 PubMed GONUTS page

[PMID:17207780-24] 24.0 ^24.1 ^24.2 Radley, JJ et al. (2007) Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines. Brain Res. 1134 87-94 PubMed GONUTS page

[PMID:19298817-25] Swanwick, CC et al. (2009) NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins. FEBS Lett. 583 1226-30 PubMed GONUTS page

[PMID:17050728-26] 26.0 ^26.1 ^26.2 Qian, A & Johnson, JW (2006) Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors. J. Neurosci. 26 10899-910 PubMed GONUTS page

[PMID:15102920-27] Ning, K et al. (2004) Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN. J. Neurosci. 24 4052-60 PubMed GONUTS page

[PMID:15069201-28] Gingrich, JR et al. (2004) Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc. Natl. Acad. Sci. U.S.A. 101 6237-42 PubMed GONUTS page

[PMID:22098737-29] 29.0 ^29.1 Talukder, I et al. (2011) GluN1-specific redox effects on the kinetic mechanism of NMDA receptor activation. Biophys. J. 101 2389-98 PubMed GONUTS page

[PMID:19918184-30] Han, LC et al. (2010) The effect of ketamine on N-methyl-D-aspartate receptor subunit expression in neonatal rats. Eur J Anaesthesiol 27 181-6 PubMed GONUTS page

[PMID:19322657-31] Bersier, MG & Rodríguez de Lores Arnaiz, G (2009) Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Neurochem. Res. 34 1650-7 PubMed GONUTS page

[PMID:21314939-32] Gardoni, F et al. (2011) Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation. J Neuroinflammation 8 14 PubMed GONUTS page

[PMID:20168047-33] Fukumori, R et al. (2010) Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. J. Pharmacol. Sci. 112 273-81 PubMed GONUTS page

[PMID:12408866-34] Lee, FJ et al. (2002) Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 111 219-30 PubMed GONUTS page

[PMID:21873635-35] 35.0 ^35.1 ^35.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17003121-36] Schlief, ML et al. (2006) Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity. Proc. Natl. Acad. Sci. U.S.A. 103 14919-24 PubMed GONUTS page

[PMID:15978582-37] Burkhardt, C et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579 3821-8 PubMed GONUTS page

[PMID:15681343-38] Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:7929101-39] Chazot, PL et al. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269 24403-9 PubMed GONUTS page

[PMID:12535174-40] 40.0 ^40.1 ^40.2 ^40.3 Lee, PR et al. (2003) Thyroid hormone regulation of N-methyl-D-aspartic acid receptor subunit mRNA expression in adult brain. J. Neuroendocrinol. 15 87-92 PubMed GONUTS page

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