RAT:NLGN1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nlgn1
Protein Name(s)	Neuroligin-1 Neuroligin I
External Links
UniProt	Q62765
EMBL	U22952
RefSeq	NP_446320.1
UniGene	Rn.10173
PDB	3BIW 3BIX 3VKF
PDBsum	3BIW 3BIX 3VKF
ProteinModelPortal	Q62765
SMR	Q62765
BioGrid	250532
DIP	DIP-44832N
IntAct	Q62765
MINT	MINT-1526995
STRING	10116.ENSRNOP00000049486
MEROPS	S09.994
PaxDb	Q62765
PRIDE	Q62765
Ensembl	ENSRNOT00000041111 ENSRNOT00000043276
GeneID	116647
KEGG	rno:116647
UCSC	RGD:621117
CTD	22871
RGD	621117
eggNOG	COG2272
GeneTree	ENSGT00760000118946
HOGENOM	HOG000231424
HOVERGEN	HBG008839
InParanoid	Q62765
KO	K07378
OMA	KFVELIV
OrthoDB	EOG7RBZ7R
PhylomeDB	Q62765
TreeFam	TF326187
EvolutionaryTrace	Q62765
NextBio	619391
PRO	PR:Q62765
Proteomes	UP000002494
Genevestigator	Q62765
GO	GO:0030054 GO:0009986 GO:0030425 GO:0060076 GO:0009897 GO:0032433 GO:0005887 GO:0014069 GO:0045211 GO:0045202 GO:0050839 GO:0042043 GO:0046983 GO:0004872 GO:0097113 GO:0016339 GO:0048789 GO:0045184 GO:0007157 GO:0097114 GO:0007399 GO:0097115 GO:0007158 GO:0045161 GO:0060999 GO:2000463 GO:0051491 GO:1902533 GO:1900029 GO:0051965 GO:0032230 GO:0051968 GO:1900244 GO:2000302 GO:0097119 GO:0097104 GO:0097105 GO:0051290 GO:0051260 GO:0035418 GO:0006605 GO:0097120 GO:2000311 GO:2000310 GO:0045664 GO:0002087 GO:0007416 GO:0050808 GO:0097091 GO:0016080 GO:0072553
Gene3D	3.40.50.1820
InterPro	IPR029058 IPR002018 IPR019819 IPR000460 IPR030022
PANTHER	PTHR11559:SF52
Pfam	PF00135
PRINTS	PR01090
SUPFAM	SSF53474
PROSITE	PS00941

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0097119	postsynaptic density protein 95 clustering	PMID:12930820^[1]	ECO:0000315			P		Figure 2B, showed clustering of PSD-95 when HEK293 cells transfected with wild type Nlgn1,but mutated Nlgn1 showed no clustering of PSD-95, figure 2c.	complete CACAO 2945
	GO:0097105	presynaptic membrane assembly	PMID:19628693^[2]	ECO:0000315			P		To investigate maturation of presynaptic bouton, presynaptic markers were used Basson. Figure 1 shows increase in Basson expression when hippocampal neurons were transfected with over expression of Nlgn1, by 2.3 fold, figure 1. Similar result are seen in figure 4G, SV (synaptic vesicle) recycling was impaired when Nlgn1 is mutated. SV trafficking is part of presynaptic maturation.	complete CACAO 3155
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:19628693^[2]	ECO:0000315			P		Figure 4A, B showed increase mini frequency in Nlgn1 overexpression compared to non-transfected cells. Figure 4C and D, when NMDA receptors blocker is used EPSC amplitude was decrease.	complete CACAO 3156
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:19628693^[2]	ECO:0000315			P		Figure 4C and D, when NMDA receptors blocker is used EPSC amplitude was decreased.	complete CACAO 3157
	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	PMID:19628693^[2]	ECO:0000315			P		Figure 4C and D, when NMDA receptors blocker is used EPSC amplitude was decreased.	complete CACAO 3158
	GO:0048489	synaptic vesicle transport	PMID:19628693^[2]	ECO:0000315			P		Figure 4G, SV (synaptic vesicle) recycling was impaired when Nlgn1 is mutated. SV trafficking is part of presynaptic maturation. Over expression of Nlgn1 increased SV at bouton figure 4F.	complete CACAO 3159
	GO:0030425	dendrite	PMID:19450252^[3]	ECO:0000314			C		Additional file 1A show Nlgn1 localized to dendrite, also seen in figure 1C	complete
	GO:0097091	synaptic vesicle clustering	PMID:19628693^[2]	ECO:0000315			P		Figure S3 increased synaptic vesicle clustering to synapse when Nlgn1 over expressed	complete CACAO 3160
	GO:0009986	cell surface	PMID:19459252^[4]	ECO:0000314			C		Figure 1A,B located at the surface of the cell.	complete
	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	PMID:12930820^[1]	ECO:0000314			P		Figure 1A and 1B, Nlgn1 transfected in HEK293 cell with NR1-1a/NR2A, showed NMDA receptor mediated mEPSE. This is not seen when Nlgn1 in not transfected in HEK293 cells. Similar results seen in figure 3A and B.	complete
	GO:0032433	filopodium tip	PMID:19450252^[3]	ECO:0000314			C		Cluster of Nlgn1 found in highly active filopodia where Nlgn1 is targeted towards the tip of the filopodia , figure 1C.	complete CACAO 3165
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:12930820^[1]	ECO:0000314			P		Figure 1A and 1B, Nlgn1 transfected in HEK293 cell with NR1-1a/NR2A, showed NMDA receptor mediated mEPSE. This is not seen when Nlgn1 in not transfected in HEK293 cells. Similar results seen in figure 3A and B.	complete
	GO:0097119	postsynaptic density protein 95 clustering	PMID:19450252^[3]	ECO:0000315			P		Figure 4A-E showed Patching of Nlgn1 increased in PSD-95 clustering. Figure 5A,B showed increase of PSD-95 clustering by 31% when neurons were transfected with Nlgn1.	complete CACAO 3166
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:12930820^[1]	ECO:0000314			P		Figure 1A and 1B. Nlgn1 transfected in HEK293 cell with NR1-1a/NR2A showed NMDA mediated mEPSE. This is not seen when Nlgn1 in not transfected in HEK293 cells, Similar results seen in figure 3A and B.	complete
	GO:0097114	N-methyl-D-aspartate receptor clustering	PMID:19450252^[3]	ECO:0000314			P		Figure 6D showed that patching of Nlgn1 clustered NR1 at synaptic location	complete CACAO 3167
	GO:0005886	plasma membrane	PMID:12930820^[1]	ECO:0000314			C		Figure 2A, Nlgn1 found on edge of cell therefore located at plasma membrane	complete
involved_in	GO:1905520	positive regulation of presynaptic active zone assembly	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0140058	neuron projection arborization	PMID:22750515^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P58400	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:22750515^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P58400	P	occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:14522992^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:14522992^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63373	F	part_of:(GO:0071277)	Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:25428619^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:25428619^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P	transports_or_maintains_localization_of:(UniProtKB:O08835)	Seeded From UniProt	complete
involved_in	GO:0098942	retrograde trans-synaptic signaling by trans-synaptic protein complex	PMID:17237775^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0000598) occurs_in:(UBERON:0003881) regulates:(GO:0007268)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15519238^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
colocalizes_with	GO:0014069	postsynaptic density	PMID:15519238^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:15519238^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15519238^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0030425) part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:19450252^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048489	synaptic vesicle transport	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:12930820^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:20534458^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:20534458^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(GO:0048786) occurs_in:(CL:0000540) occurs_in:(GO:0030425)	Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P	occurs_in:(CL:1001571)	Seeded From UniProt	complete
involved_in	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19730411^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902533	positive regulation of intracellular signal transduction	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900029	positive regulation of ruffle assembly	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	PMID:21940442^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:19730411^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0060080	inhibitory postsynaptic potential	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:17582332^[12]	ECO:0000305	curator inference used in manual assertion	GO:2000463	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	PMID:19730411^[13]	ECO:0000305	curator inference used in manual assertion	GO:2000463	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:19730411^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:19730411^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:15797875^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	PMID:19628693^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:19730411^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:15797875^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:19730411^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63373	F		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
part_of	GO:0032433	filopodium tip	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032230	positive regulation of synaptic transmission, GABAergic	PMID:12930820^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17582332^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0017146	NMDA selective glutamate receptor complex	PMID:19450252^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19730411^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:15797875^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:9278515^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:9325340^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	PMID:9278515^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99K10	C		Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0000988)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(UBERON:0000988)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0000988)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099174	regulation of presynapse organization	PMID:10892652^[17]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0000988)	Seeded From UniProt	complete
part_of	GO:0099060	integral component of postsynaptic specialization membrane	PMID:9927700^[18]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:9927700^[18]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:1902474	positive regulation of protein localization to synapse	PMID:15681343^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:15681343^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:23083734^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	PMID:18093522^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:22539981^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:18093522^[21]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2444609 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117	P		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0083963 PANTHER:PTN000168538	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 MGI:MGI:2681835 MGI:MGI:3775191 PANTHER:PTN000168538 RGD:621117 RGD:621119 WB:WBGene00006412	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031866 MGI:MGI:2179435 MGI:MGI:2681835 PANTHER:PTN000168538 RGD:621117 RGD:621119 UniProtKB:Q8N0W4	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000168538 RGD:621117 RGD:621119	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119 UniProtKB:Q8N0W4 UniProtKB:Q9NZ94	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 RGD:621117 RGD:621118 RGD:621119	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2179435 PANTHER:PTN000168538 UniProtKB:Q8N0W4	C		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:15681343^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016080	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048488	C		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	F		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8N2Q7 ensembl:ENSP00000392500	F		Seeded From UniProt	complete
involved_in	GO:2000809	positive regulation of synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:2000302	positive regulation of synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:1904861	excitatory synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:1900244	positive regulation of synaptic vesicle endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0098698	postsynaptic specialization assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097115	neurexin clustering involved in presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097113	AMPA glutamate receptor clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0072553	terminal button organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0061002	negative regulation of dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0051965	positive regulation of synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0048789	cytoskeletal matrix organization at active zone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	F		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	C		Seeded From UniProt	complete
involved_in	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99K10 ensembl:ENSMUSP00000142200	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460	C		Seeded From UniProt	complete
enables	GO:0042043	neurexin family protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000460 InterPro:IPR030022	F		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030022	C		Seeded From UniProt	complete
involved_in	GO:0045161	neuronal ion channel clustering	PMID:9278515^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-RNO-6797307	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Wittenmayer, N et al. (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc. Natl. Acad. Sci. U.S.A. 106 13564-9 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page
↑ () PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page
↑ ^6.0 ^6.1 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page
↑ ^7.0 ^7.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page
↑ ^8.0 ^8.1 Fang, M et al. (2016) Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Mol. Neurobiol. 53 270-284 PubMed GONUTS page
↑ Futai, K et al. (2007) Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat. Neurosci. 10 186-95 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Dresbach, T et al. (2004) Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol. Cell. Neurosci. 27 227-35 PubMed GONUTS page
↑ ^11.0 ^11.1 Stan, A et al. (2010) Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc. Natl. Acad. Sci. U.S.A. 107 11116-21 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page
↑ Mondin, M et al. (2011) Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. J. Neurosci. 31 13500-15 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Irie, M et al. (1997) Binding of neuroligins to PSD-95. Science 277 1511-5 PubMed GONUTS page
↑ Nguyen, T & Südhof, TC (1997) Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 26032-9 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Scheiffele, P et al. (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101 657-69 PubMed GONUTS page
↑ ^18.0 ^18.1 Song, JY et al. (1999) Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc. Natl. Acad. Sci. U.S.A. 96 1100-5 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page
↑ Shipman, SL & Nicoll, RA (2012) A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP. Neuron 76 309-16 PubMed GONUTS page
↑ ^21.0 ^21.1 Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page
↑ Jackson, J et al. (2012) Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. PLoS ONE 7 e35557 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 ^23.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12930820-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Fu, Z et al. (2003) Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J. Neurophysiol. 90 3950-7 PubMed GONUTS page

[PMID:19628693-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 Wittenmayer, N et al. (2009) Postsynaptic Neuroligin1 regulates presynaptic maturation. Proc. Natl. Acad. Sci. U.S.A. 106 13564-9 PubMed GONUTS page

[PMID:19450252-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page

[PMID:19459252-4] () PubMed GONUTS page

[PMID:15797875-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Chubykin, AA et al. (2005) Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J. Biol. Chem. 280 22365-74 PubMed GONUTS page

[PMID:22750515-6] 6.0 ^6.1 Gjørlund, MD et al. (2012) Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1. FASEB J. 26 4174-86 PubMed GONUTS page

[PMID:14522992-7] 7.0 ^7.1 Comoletti, D et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J. Biol. Chem. 278 50497-505 PubMed GONUTS page

[PMID:25428619-8] 8.0 ^8.1 Fang, M et al. (2016) Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Mol. Neurobiol. 53 270-284 PubMed GONUTS page

[PMID:17237775-9] Futai, K et al. (2007) Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat. Neurosci. 10 186-95 PubMed GONUTS page

[PMID:15519238-10] 10.0 ^10.1 ^10.2 ^10.3 Dresbach, T et al. (2004) Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Mol. Cell. Neurosci. 27 227-35 PubMed GONUTS page

[PMID:20534458-11] 11.0 ^11.1 Stan, A et al. (2010) Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation. Proc. Natl. Acad. Sci. U.S.A. 107 11116-21 PubMed GONUTS page

[PMID:17582332-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 ^12.9 Chubykin, AA et al. (2007) Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron 54 919-31 PubMed GONUTS page

[PMID:19730411-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 ^13.7 Ko, J et al. (2009) Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28 3244-55 PubMed GONUTS page

[PMID:21940442-14] Mondin, M et al. (2011) Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. J. Neurosci. 31 13500-15 PubMed GONUTS page

[PMID:9278515-15] 15.0 ^15.1 ^15.2 Irie, M et al. (1997) Binding of neuroligins to PSD-95. Science 277 1511-5 PubMed GONUTS page

[PMID:9325340-16] Nguyen, T & Südhof, TC (1997) Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. J. Biol. Chem. 272 26032-9 PubMed GONUTS page

[PMID:10892652-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 ^17.7 Scheiffele, P et al. (2000) Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101 657-69 PubMed GONUTS page

[PMID:9927700-18] 18.0 ^18.1 Song, JY et al. (1999) Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc. Natl. Acad. Sci. U.S.A. 96 1100-5 PubMed GONUTS page

[PMID:15681343-19] 19.0 ^19.1 ^19.2 Chih, B et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science 307 1324-8 PubMed GONUTS page

[PMID:23083734-20] Shipman, SL & Nicoll, RA (2012) A subtype-specific function for the extracellular domain of neuroligin 1 in hippocampal LTP. Neuron 76 309-16 PubMed GONUTS page

[PMID:18093522-21] 21.0 ^21.1 Araç, D et al. (2007) Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56 992-1003 PubMed GONUTS page

[PMID:22539981-22] Jackson, J et al. (2012) Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult. PLoS ONE 7 e35557 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 ^23.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NLGN1

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