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PMID:9278515
| Citation |
Irie, M, Hata, Y, Takeuchi, M, Ichtchenko, K, Toyoda, A, Hirao, K, Takai, Y, Rosahl, TW and Südhof, TC (1997) Binding of neuroligins to PSD-95. Science 277:1511-5 |
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| Abstract |
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins. |
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| Keywords |
Amino Acid Sequence; Animals; COS Cells; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion Molecules, Neuronal; Cell Line; Cell Membrane/metabolism; Cytoplasm/metabolism; Guanylate Kinase; Intercellular Junctions/metabolism; Intracellular Signaling Peptides and Proteins; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/metabolism; Neurons/metabolism; Nucleoside-Phosphate Kinase/metabolism; Potassium Channels/metabolism; Prosencephalon/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Recombinant Fusion Proteins/metabolism; Tumor Suppressor Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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References
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