PMID:17237775

Citation	Futai, K, Kim, MJ, Hashikawa, T, Scheiffele, P, Sheng, M and Hayashi, Y (2007) Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat. Neurosci. 10:186-95
Abstract	The structure and function of presynaptic and postsynaptic components of the synapse are highly coordinated. How such coordination is achieved and the molecules involved in this process have not been clarified. Several lines of evidence suggest that presynaptic functionalities are regulated by retrograde mechanisms from the postsynaptic side. We therefore sought postsynaptic mechanisms responsible for trans-synaptic regulation of presynaptic function at excitatory synapses in rat hippocampal CA1 pyramidal neurons. We show here that the postsynaptic complex of scaffolding protein PSD-95 and neuroligin can modulate the release probability of transmitter vesicles at synapse in a retrograde way, resulting in altered presynaptic short-term plasticity. Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function.
Links	PubMed PMC4755312 Online version:10.1038/nn1837
Keywords	Animals; Cell Adhesion Molecules, Neuronal; Disks Large Homolog 4 Protein; Excitatory Postsynaptic Potentials/physiology; Hippocampus/cytology; Hippocampus/metabolism; Intracellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Nerve Tissue Proteins/metabolism; Neuronal Plasticity/physiology; Neurotransmitter Agents/metabolism; Organ Culture Techniques; Presynaptic Terminals/metabolism; Presynaptic Terminals/ultrastructure; Probability; Protein Transport/physiology; Pyramidal Cells/metabolism; Pyramidal Cells/ultrastructure; Rats; Signal Transduction/physiology; Synaptic Membranes/metabolism; Synaptic Membranes/ultrastructure; Synaptic Transmission/physiology; Synaptic Vesicles/metabolism; Synaptic Vesicles/ultrastructure
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:NLGN1	involved_in	GO:0098942: retrograde trans-synaptic signaling by trans-synaptic protein complex	ECO:0000315: mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0060076) occurs_in:(CL:0000598) occurs_in:(UBERON:0003881) regulates:(GO:0007268)	Seeded From UniProt	complete

References

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