GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

RAT:MSH2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Msh2
Protein Name(s) DNA mismatch repair protein Msh2

MutS protein homolog 2

External Links
UniProt P54275
EMBL X93591
PIR JC6184
RefSeq NP_112320.1
UniGene Rn.3174
ProteinModelPortal P54275
SMR P54275
BioGrid 249587
PhosphoSite P54275
PaxDb P54275
PRIDE P54275
GeneID 81709
KEGG rno:81709
UCSC RGD:620786
CTD 4436
RGD 620786
eggNOG COG0249
HOGENOM HOG000196498
HOVERGEN HBG006399
InParanoid P54275
KO K08735
PhylomeDB P54275
NextBio 615336
PRO PR:P54275
Proteomes UP000002494
Genevestigator P54275
GO GO:0032301
GO:0032302
GO:0000228
GO:0005634
GO:0005524
GO:0003684
GO:0003677
GO:0008094
GO:0000406
GO:0000400
GO:0032137
GO:0000404
GO:0032138
GO:0000403
GO:0006200
GO:0006302
GO:0031573
GO:0042771
GO:0045190
GO:0043570
GO:0006311
GO:0000710
GO:0045128
GO:0006301
GO:0043200
GO:0042493
GO:0014070
GO:0010224
GO:0010165
GO:0016446
GO:0007283
Gene3D 3.40.50.300
InterPro IPR011184
IPR007695
IPR000432
IPR007861
IPR007696
IPR007860
IPR027417
Pfam PF01624
PF05188
PF05192
PF05190
PF00488
PIRSF PIRSF005813
SMART SM00534
SM00533
SUPFAM SSF48334
SSF52540
PROSITE PS00486

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032301

MutSalpha complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43246

C

Seeded From UniProt

complete

involved_in

GO:0006301

postreplication repair

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43246

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P43246

F

Seeded From UniProt

complete

involved_in

GO:0043200

response to amino acid

PMID:11026496[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:11056294[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:18095365[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:9034308[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9473709[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045910

negative regulation of DNA recombination

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145640
TAIR:locus:2095097
UniProtKB:P43246

P

Seeded From UniProt

complete

involved_in

GO:0043570

maintenance of DNA repeat elements

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015546
PANTHER:PTN000145640
PomBase:SPBC19G7.01c
UniProtKB:P43246
WB:WBGene00003418
ZFIN:ZDB-GENE-040426-2932

P

Seeded From UniProt

complete

involved_in

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145643
WB:WBGene00003418

P

Seeded From UniProt

complete

part_of

GO:0032302

MutSbeta complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145640
SGD:S000005450
UniProtKB:P43246

C

Seeded From UniProt

complete

part_of

GO:0032301

MutSalpha complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145640
SGD:S000005450
UniProtKB:P43246

C

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779

C

Seeded From UniProt

complete

contributes_to

GO:0032143

single thymine insertion binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

contributes_to

GO:0032137

guanine/thymine mispair binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:1343961
PANTHER:PTN002260779
SGD:S000001162
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145643

P

Seeded From UniProt

complete

involved_in

GO:0010224

response to UV-B

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145643

P

Seeded From UniProt

complete

involved_in

GO:0010165

response to X-ray

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145643

P

Seeded From UniProt

complete

enables

GO:0008094

DNA-dependent ATPase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002260779
SGD:S000001162

F

Seeded From UniProt

complete

involved_in

GO:0006302

double-strand break repair

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145643

P

Seeded From UniProt

complete

involved_in

GO:0006301

postreplication repair

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145640
UniProtKB:P43246

P

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
FB:FBgn0015546
MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN000145505
PomBase:SPBC19G7.01c
PomBase:SPCC285.16c
SGD:S000000688
SGD:S000001162
SGD:S000002504
SGD:S000005450
TAIR:locus:2095097
UniProtKB:P20585
UniProtKB:P43246
UniProtKB:P52701
WB:WBGene00003418
WB:WBGene00003422

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
PANTHER:PTN000145640
RGD:620786
SGD:S000005450
UniProtKB:P43246

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450
UniProtKB:P43246
UniProtKB:P52701

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10625
PANTHER:PTN002260779
SGD:S000002504
SGD:S000005450

F

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101816
MGI:MGI:109519
MGI:MGI:1343961
PANTHER:PTN002260779
TAIR:locus:2095097
TAIR:locus:2131829
UniProtKB:O04716

F

Seeded From UniProt

complete

contributes_to

GO:0000400

four-way junction DNA binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000145640
UniProtKB:P43246

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032642

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR011184
InterPro:IPR016151
InterPro:IPR032642
InterPro:IPR036678

F

Seeded From UniProt

complete

involved_in

GO:0006298

mismatch repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR011184
InterPro:IPR016151
InterPro:IPR032642
InterPro:IPR036678

P

Seeded From UniProt

complete

enables

GO:0030983

mismatched DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000432
InterPro:IPR007695
InterPro:IPR007696
InterPro:IPR007860
InterPro:IPR007861
InterPro:IPR011184
InterPro:IPR016151
InterPro:IPR036678

F

Seeded From UniProt

complete

part_of

GO:0032300

mismatch repair complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR032642

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Uberti, D et al. (2000) Induction of p53 in the glutamate-induced cell death program. Amino Acids 19 253-61 PubMed GONUTS page
  2. ↑ Harrouk, W et al. (2000) Paternal exposure to cyclophosphamide induces DNA damage and alters the expression of DNA repair genes in the rat preimplantation embryo. Mutat. Res. 461 229-41 PubMed GONUTS page
  3. ↑ Dihal, AA et al. (2008) Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. Proteomics 8 45-61 PubMed GONUTS page
  4. ↑ Vani, RG & Rao, MR (1997) Cloning of the cDNA encoding rat homologue of the mismatch repair gene MSH2 and its expression during spermatogenesis. Gene 185 19-26 PubMed GONUTS page
  5. ↑ Marietta, C et al. (1998) Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain. Brain Res. Mol. Brain Res. 53 317-20 PubMed GONUTS page
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 6.12 6.13 6.14 6.15 6.16 6.17 6.18 6.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=RAT:MSH2&oldid=5933283"