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RAT:MAOX

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Me1 (synonyms: Mod-1, Mod1)
Protein Name(s) NADP-dependent malic enzyme

NADP-ME Malic enzyme 1

External Links
UniProt P13697
EMBL M26594
M26581
M26582
M26583
M26584
M26585
M26586
M26587
M26588
M26589
M26590
M26591
M26592
M26593
PIR A37228
UniGene Rn.3519
ProteinModelPortal P13697
SMR P13697
STRING 10116.ENSRNOP00000013244
ChEMBL CHEMBL2293
World-2DPAGE 0004:P13697
PaxDb P13697
PRIDE P13697
UCSC RGD:3074
RGD 3074
eggNOG COG0281
HOGENOM HOG000042486
HOVERGEN HBG000746
InParanoid P13697
PhylomeDB P13697
SABIO-RK P13697
Proteomes UP000002494
Genevestigator P13697
GO GO:0005829
GO:0004471
GO:0004473
GO:0004470
GO:0030145
GO:0051287
GO:0050661
GO:0008948
GO:0006108
GO:0009725
Gene3D 3.40.50.10380
3.40.50.720
InterPro IPR015884
IPR012301
IPR012302
IPR001891
IPR016040
Pfam PF00390
PF03949
PIRSF PIRSF000106
PRINTS PR00072
SMART SM00919
PROSITE PS00331

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005739

mitochondrion

PMID:9681477[1]

ECO:0000314

C

See Figure 2.

complete
CACAO 5782

part_of

GO:0005739

mitochondrion

PMID:9681477[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:7622060[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

F

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

PMID:2416344[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:8187880[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

P

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:7622060[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:2416344[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:2416344[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:8187880[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:8187880[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:7622060[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48163

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:17447164[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:18062843[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:17447164[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:11735100[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002719
PANTHER:PTN000601050
PomBase:SPCC794.12c
TAIR:locus:2017854
TAIR:locus:2052045
TAIR:locus:2054085
TAIR:locus:2127038
TAIR:locus:2180547
TAIR:locus:2181980
UniProtKB:P48163
UniProtKB:Q16798

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
PomBase:SPCC794.12c
SGD:S000001512
UniProtKB:Q16798

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001157886
RGD:3074
UniProtKB:F1N3V0
UniProtKB:P23368

C

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002719
MGI:MGI:97043
PANTHER:PTN000601052
RGD:3074
TAIR:locus:2017854
TAIR:locus:2052045
TAIR:locus:2180547
TAIR:locus:2181980
UniProtKB:P48163
UniProtKB:Q16798

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
RGD:3074
SGD:S000001512
UniProtKB:P23368
UniProtKB:P48163
UniProtKB:Q16798

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891

F

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891
InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012302

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

P

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0008948

oxaloacetate decarboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vogel, R et al. (1998) Mitochondrial malic enzyme: purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain. J. Neurochem. 71 844-52 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 González-Manchón, C et al. (1995) Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene 159 255-60 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Dozin, B et al. (1985) Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Biochemistry 24 5581-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Loeber, G et al. (1994) Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 344 181-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 Tylicki, A et al. (2007) Effect of anabolic steroid nandrolone decanoate on the properties of certain enzymes in the heart, liver, and muscle of rats, and their effect on rats' cardiac electrophysiology. Horm. Metab. Res. 39 268-72 PubMed GONUTS page
  6. ↑ Huong, DT & Ide, T (2008) Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br. J. Nutr. 100 79-87 PubMed GONUTS page
  7. ↑ Moura, MA et al. (2001) Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Metab. Clin. Exp. 50 1493-8 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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