RAT:LYN

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Lyn
Protein Name(s)	Tyrosine-protein kinase Lyn V-yes-1 Yamaguchi sarcoma viral related oncogene homolog p53Lyn p56Lyn
External Links
UniProt	Q07014
EMBL	L14951 L14782 L14823 AF000300 AF000301 AF000302
PIR	I56160 PT0198
RefSeq	NP_001104568.1 NP_110484.1 XP_006237896.1
UniGene	Rn.4338
ProteinModelPortal	Q07014
SMR	Q07014
BioGrid	249512
IntAct	Q07014
MINT	MINT-4564766
STRING	10116.ENSRNOP00000011130
BindingDB	Q07014
ChEMBL	CHEMBL4363
iPTMnet	Q07014
PhosphoSite	Q07014
PaxDb	Q07014
PRIDE	Q07014
Ensembl	ENSRNOT00000011130
GeneID	81515
KEGG	rno:81515
UCSC	RGD:621017
CTD	4067
RGD	621017
eggNOG	KOG0197 COG0515
GeneTree	ENSGT00760000118938
HOGENOM	HOG000233858
HOVERGEN	HBG008761
InParanoid	Q07014
KO	K05854
OMA	WWRAKSL
OrthoDB	EOG7GTT2V
PhylomeDB	Q07014
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	R-RNO-114604 R-RNO-1433557 R-RNO-1433559 R-RNO-202733 R-RNO-2454202 R-RNO-389356 R-RNO-389513 R-RNO-3928662 R-RNO-3928663 R-RNO-3928665 R-RNO-5621575 R-RNO-75892 R-RNO-982772
NextBio	615007
PRO	PR:Q07014
Proteomes	UP000002494
Genevisible	Q07014
GO	GO:0005913 GO:0005737 GO:0070062 GO:0031234 GO:0005794 GO:0034666 GO:0042629 GO:0016020 GO:0045121 GO:0030061 GO:0005758 GO:0031966 GO:0005634 GO:0048471 GO:0005886 GO:0014069 GO:0005524 GO:0019899 GO:0043015 GO:0043208 GO:0005178 GO:0016301 GO:0004715 GO:0051219 GO:0005161 GO:0032403 GO:0004713 GO:0005102 GO:0031625 GO:0002250 GO:0001782 GO:0050853 GO:0006974 GO:0031668 GO:0034605 GO:0071300 GO:0050663 GO:0097028 GO:0030218 GO:0002774 GO:0002431 GO:0002553 GO:0002768 GO:0045087 GO:0035556 GO:0031663 GO:0030889 GO:0008285 GO:0070373 GO:1902532 GO:0043407 GO:0070667 GO:0002762 GO:0001933 GO:0034136 GO:0034144 GO:0031175 GO:0014003 GO:0038083 GO:0002576 GO:0050861 GO:0030335 GO:0008284 GO:2000670 GO:0060369 GO:0060252 GO:0070668 GO:0010976 GO:0070447 GO:0043552 GO:0042327 GO:0070304 GO:0042531 GO:0002902 GO:0050855 GO:0033628 GO:0001817 GO:0050707 GO:0070372 GO:0045646 GO:0050727 GO:0033003 GO:0043304 GO:0090025 GO:0090330 GO:0051279 GO:0043200 GO:0048678 GO:0009743 GO:0042493 GO:0009725 GO:0032868 GO:0014070 GO:0043434 GO:0006991 GO:0009636 GO:0002513 GO:0007169
Gene3D	3.30.505.10
InterPro	IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635
Pfam	PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00109
SMART	SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005758	mitochondrial intermembrane space	PMID:27087918^[1]	ECO:0000314			C		IDA Figure 11 shows immunogold detection of lyn in rat brain mitrochondrial intermembrane space.	complete CACAO 11816
	GO:0044290	mitochondrial intracristal space	PMID:27087918^[1]	ECO:0000314			C		Figure 11 shows immunogold detection of lyn in rat brain mitrochondrial cristal lumen (intracristal space).	complete CACAO 11935
involved_in	GO:2000670	positive regulation of dendritic cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:1902532	negative regulation of intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0097028	dendritic cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0070667	negative regulation of mast cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0050855	regulation of B cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0045646	regulation of erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0043304	regulation of mast cell degranulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0033003	regulation of mast cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	C		Seeded From UniProt	complete
involved_in	GO:0002774	Fc receptor mediated inhibitory signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0002768	immune response-regulating cell surface receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0002513	tolerance induction to self antigen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0002431	Fc receptor mediated stimulatory signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25911	P		Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:14529711^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:14529711^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:14529711^[2]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:14529711^[2]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation	PMID:15504915^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway	PMID:16177098^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	PMID:15504915^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051279	regulation of release of sequestered calcium ion into cytosol	PMID:16177098^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:8910399^[5]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2598	F		Seeded From UniProt	complete
involved_in	GO:0050663	cytokine secretion	PMID:16177098^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	PMID:17918263^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:10545487^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:18326662^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:12681493^[9]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1557394 RGD:1563421 RGD:708436	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:18234883^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:17579026^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:16713446^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043208	glycosphingolipid binding	PMID:8106508^[13]	ECO:0000353	physical interaction evidence used in manual assertion	PubChem_Compound:6450237	F		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	PMID:16529858^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	PMID:10545487^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17039281^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:16177098^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034666	integrin alpha2-beta1 complex	PMID:18234883^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:12372808^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:12089355^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:12007793^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	PMID:17845203^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:14531861^[20]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620535	F		Seeded From UniProt	complete
part_of	GO:0030061	mitochondrial crista	PMID:12007793^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:9692543^[21]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:67383	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:8757630^[22]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:71096	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:8190127^[23]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3796	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:18579528^[24]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620521	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:14529711^[2]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620224	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16177098^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:17265464^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:15287886^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:14529711^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014003	oligodendrocyte development	PMID:15504915^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009743	response to carbohydrate	PMID:10330413^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:16529858^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006991	response to sterol depletion	PMID:10330413^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	PMID:1709169^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18579528^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:12007793^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:15504915^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:15504915^[3]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3284	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:8870703^[29]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3860	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:16177098^[4]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2598	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11714805^[30]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:61978	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11591756^[31]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2599	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:12007793^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002553	histamine secretion by mast cell	PMID:16177098^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000670	positive regulation of dendritic cell apoptotic process	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0097028	dendritic cell differentiation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0070667	negative regulation of mast cell proliferation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0050855	regulation of B cell receptor signaling pathway	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0043304	regulation of mast cell degranulation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:Q9H3Y6 WB:WBGene00005077	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P08631	C		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 RGD:621423	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521528 UniProtKB:P07948	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000701011 UniProtKB:P07948	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0262733 PANTHER:PTN002521528 RGD:2641 RGD:620795 RGD:621017 UniProtKB:P12931	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95527 PANTHER:PTN002521528 UniProtKB:P09769 UniProtKB:P51451 UniProtKB:Q13882 WB:WBGene00005077	F		Seeded From UniProt	complete
involved_in	GO:0002902	regulation of B cell apoptotic process	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0002513	tolerance induction to self antigen	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
involved_in	GO:0002431	Fc receptor mediated stimulatory signaling pathway	PMID:21873635^[32]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96892 PANTHER:PTN000701011	P		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0002553	C		Seeded From UniProt	complete
involved_in	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
enables	GO:0140031	phosphorylation-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	F		Seeded From UniProt	complete
involved_in	GO:0090025	regulation of monocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0070668	positive regulation of mast cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
enables	GO:0046875	ephrin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
involved_in	GO:0033628	regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07948 ensembl:ENSP00000428924	P		Seeded From UniProt	complete
involved_in	GO:2000670	positive regulation of dendritic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:1902532	negative regulation of intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0097028	dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0070667	negative regulation of mast cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0051279	regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0050855	regulation of B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0045646	regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	F		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0043304	regulation of mast cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0033003	regulation of mast cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	F		Seeded From UniProt	complete
involved_in	GO:0002902	regulation of B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002774	Fc receptor mediated inhibitory signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002768	immune response-regulating cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002762	negative regulation of myeloid leukocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002513	tolerance induction to self antigen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0002431	Fc receptor mediated stimulatory signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0001817	regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P25911 ensembl:ENSMUSP00000038838	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:12007793^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lim, S et al. (2016) Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation. Cell Biosci 6 25 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kalia, LV & Salter, MW (2003) Interactions between Src family protein tyrosine kinases and PSD-95. Neuropharmacology 45 720-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Colognato, H et al. (2004) Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J. Cell Biol. 167 365-75 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Vonakis, BM et al. (2005) Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI). J. Immunol. 175 4543-54 PubMed GONUTS page
↑ Kimura, T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J. Biol. Chem. 271 27962-8 PubMed GONUTS page
↑ Tsuda, M et al. (2008) Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 56 50-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Dráberová, L et al. (1999) Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells. Int. Immunol. 11 1829-39 PubMed GONUTS page
↑ Das, R et al. (2008) Real-time cross-correlation image analysis of early events in IgE receptor signaling. Biophys. J. 94 4996-5008 PubMed GONUTS page
↑ Fujii, Y et al. (2003) Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 540 111-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Alessandri-Haber, N et al. (2008) Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046-57 PubMed GONUTS page
↑ Leung, WH & Bolland, S (2007) The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J. Immunol. 179 95-102 PubMed GONUTS page
↑ Pace, A et al. (2006) The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules. Biochim. Biophys. Acta 1763 356-65 PubMed GONUTS page
↑ Minoguchi, K et al. (1994) Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells. J. Biol. Chem. 269 5249-54 PubMed GONUTS page
↑ ^14.0 ^14.1 Napolitano, M et al. (2006) L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases. Neurosci. Lett. 398 211-4 PubMed GONUTS page
↑ He, H et al. (2006) Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. Cardiovasc Drugs Ther 20 259-71 PubMed GONUTS page
↑ Fazal, N et al. (2002) Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury. Am. J. Physiol., Cell Physiol. 283 C1469-79 PubMed GONUTS page
↑ Anderwald, C et al. (2002) Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol. Endocrinol. 16 1612-28 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Salvi, M et al. (2002) Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Biochim. Biophys. Acta 1589 181-95 PubMed GONUTS page
↑ Konno, R et al. (2007) Gene expression profiling of the rat endometriosis model. Am. J. Reprod. Immunol. 58 330-43 PubMed GONUTS page
↑ Kyo, S et al. (2003) Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation. Genes Cells 8 825-36 PubMed GONUTS page
↑ Song, JS et al. (1998) Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene 16 3357-68 PubMed GONUTS page
↑ Pullar, CE et al. (1996) Rapid dephosphorylation of the GTPase dynamin after FcepsilonRI aggregation in a rat mast cell line. J. Immunol. 157 1226-32 PubMed GONUTS page
↑ Minoguchi, K et al. (1994) Src family tyrosine kinase Lyn binds several proteins including paxillin in rat basophilic leukemia cells. Mol. Immunol. 31 519-29 PubMed GONUTS page
↑ ^24.0 ^24.1 Amir-Moazami, O et al. (2008) Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. J. Biol. Chem. 283 25514-23 PubMed GONUTS page
↑ Mallozzi, C et al. (2007) L-NAME reverses quinolinic acid-induced toxicity in rat corticostriatal slices: Involvement of src family kinases. J. Neurosci. Res. 85 2770-7 PubMed GONUTS page
↑ Wu, X et al. (2004) AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression. J. Neurochem. 90 807-18 PubMed GONUTS page
↑ ^27.0 ^27.1 Sheets, ED et al. (1999) Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. J. Cell Biol. 145 877-87 PubMed GONUTS page
↑ Tsukita, S et al. (1991) Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J. Cell Biol. 113 867-79 PubMed GONUTS page
↑ Narisawa-Saito, M et al. (1996) Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells. Clin. Exp. Immunol. 106 86-90 PubMed GONUTS page
↑ Xu, R et al. (2001) SH2 domain-containing inositol polyphosphate 5'-phosphatase is the main mediator of the inhibitory action of the mast cell function-associated antigen. J. Immunol. 167 6394-402 PubMed GONUTS page
↑ Lara, M et al. (2001) Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk. J. Immunol. 167 4329-37 PubMed GONUTS page
↑ ^32.00 ^32.01 ^32.02 ^32.03 ^32.04 ^32.05 ^32.06 ^32.07 ^32.08 ^32.09 ^32.10 ^32.11 ^32.12 ^32.13 ^32.14 ^32.15 ^32.16 ^32.17 ^32.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27087918-1] 1.0 ^1.1 Lim, S et al. (2016) Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation. Cell Biosci 6 25 PubMed GONUTS page

[PMID:14529711-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kalia, LV & Salter, MW (2003) Interactions between Src family protein tyrosine kinases and PSD-95. Neuropharmacology 45 720-8 PubMed GONUTS page

[PMID:15504915-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Colognato, H et al. (2004) Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development. J. Cell Biol. 167 365-75 PubMed GONUTS page

[PMID:16177098-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Vonakis, BM et al. (2005) Regulation of rat basophilic leukemia-2H3 mast cell secretion by a constitutive Lyn kinase interaction with the high affinity IgE receptor (Fc epsilon RI). J. Immunol. 175 4543-54 PubMed GONUTS page

[PMID:8910399-5] Kimura, T et al. (1996) Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor. J. Biol. Chem. 271 27962-8 PubMed GONUTS page

[PMID:17918263-6] Tsuda, M et al. (2008) Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 56 50-8 PubMed GONUTS page

[PMID:10545487-7] 7.0 ^7.1 Dráberová, L et al. (1999) Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells. Int. Immunol. 11 1829-39 PubMed GONUTS page

[PMID:18326662-8] Das, R et al. (2008) Real-time cross-correlation image analysis of early events in IgE receptor signaling. Biophys. J. 94 4996-5008 PubMed GONUTS page

[PMID:12681493-9] Fujii, Y et al. (2003) Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 540 111-6 PubMed GONUTS page

[PMID:18234883-10] 10.0 ^10.1 Alessandri-Haber, N et al. (2008) Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J. Neurosci. 28 1046-57 PubMed GONUTS page

[PMID:17579026-11] Leung, WH & Bolland, S (2007) The inositol 5'-phosphatase SHIP-2 negatively regulates IgE-induced mast cell degranulation and cytokine production. J. Immunol. 179 95-102 PubMed GONUTS page

[PMID:16713446-12] Pace, A et al. (2006) The Src family kinase, Lyn, is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters and growth factors which stimulate its association with numerous other signaling molecules. Biochim. Biophys. Acta 1763 356-65 PubMed GONUTS page

[PMID:8106508-13] Minoguchi, K et al. (1994) Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells. J. Biol. Chem. 269 5249-54 PubMed GONUTS page

[PMID:16529858-14] 14.0 ^14.1 Napolitano, M et al. (2006) L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases. Neurosci. Lett. 398 211-4 PubMed GONUTS page

[PMID:17039281-15] He, H et al. (2006) Fosinopril and carvedilol reverse hypertrophy and change the levels of protein kinase C epsilon and components of its signaling complex. Cardiovasc Drugs Ther 20 259-71 PubMed GONUTS page

[PMID:12372808-16] Fazal, N et al. (2002) Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury. Am. J. Physiol., Cell Physiol. 283 C1469-79 PubMed GONUTS page

[PMID:12089355-17] Anderwald, C et al. (2002) Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol. Endocrinol. 16 1612-28 PubMed GONUTS page

[PMID:12007793-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Salvi, M et al. (2002) Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria. Biochim. Biophys. Acta 1589 181-95 PubMed GONUTS page

[PMID:17845203-19] Konno, R et al. (2007) Gene expression profiling of the rat endometriosis model. Am. J. Reprod. Immunol. 58 330-43 PubMed GONUTS page

[PMID:14531861-20] Kyo, S et al. (2003) Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation. Genes Cells 8 825-36 PubMed GONUTS page

[PMID:9692543-21] Song, JS et al. (1998) Tyrosine phosphorylation-dependent and -independent associations of protein kinase C-delta with Src family kinases in the RBL-2H3 mast cell line: regulation of Src family kinase activity by protein kinase C-delta. Oncogene 16 3357-68 PubMed GONUTS page

[PMID:8757630-22] Pullar, CE et al. (1996) Rapid dephosphorylation of the GTPase dynamin after FcepsilonRI aggregation in a rat mast cell line. J. Immunol. 157 1226-32 PubMed GONUTS page

[PMID:8190127-23] Minoguchi, K et al. (1994) Src family tyrosine kinase Lyn binds several proteins including paxillin in rat basophilic leukemia cells. Mol. Immunol. 31 519-29 PubMed GONUTS page

[PMID:18579528-24] 24.0 ^24.1 Amir-Moazami, O et al. (2008) Phospholipid scramblase 1 modulates a selected set of IgE receptor-mediated mast cell responses through LAT-dependent pathway. J. Biol. Chem. 283 25514-23 PubMed GONUTS page

[PMID:17265464-25] Mallozzi, C et al. (2007) L-NAME reverses quinolinic acid-induced toxicity in rat corticostriatal slices: Involvement of src family kinases. J. Neurosci. Res. 85 2770-7 PubMed GONUTS page

[PMID:15287886-26] Wu, X et al. (2004) AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression. J. Neurochem. 90 807-18 PubMed GONUTS page

[PMID:10330413-27] 27.0 ^27.1 Sheets, ED et al. (1999) Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes. J. Cell Biol. 145 877-87 PubMed GONUTS page

[PMID:1709169-28] Tsukita, S et al. (1991) Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J. Cell Biol. 113 867-79 PubMed GONUTS page

[PMID:8870703-29] Narisawa-Saito, M et al. (1996) Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells. Clin. Exp. Immunol. 106 86-90 PubMed GONUTS page

[PMID:11714805-30] Xu, R et al. (2001) SH2 domain-containing inositol polyphosphate 5'-phosphatase is the main mediator of the inhibitory action of the mast cell function-associated antigen. J. Immunol. 167 6394-402 PubMed GONUTS page

[PMID:11591756-31] Lara, M et al. (2001) Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk. J. Immunol. 167 4329-37 PubMed GONUTS page

[PMID:21873635-32] 32.00 ^32.01 ^32.02 ^32.03 ^32.04 ^32.05 ^32.06 ^32.07 ^32.08 ^32.09 ^32.10 ^32.11 ^32.12 ^32.13 ^32.14 ^32.15 ^32.16 ^32.17 ^32.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:LYN

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