RAT:ITPR1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Itpr1 (synonyms: Insp3r)
Protein Name(s)	Inositol 1,4,5-trisphosphate receptor type 1 IP3 receptor isoform 1 IP-3-R IP3R 1 InsP3R1 Type 1 inositol 1,4,5-trisphosphate receptor Type 1 InsP3 receptor
External Links
UniProt	P29994
EMBL	J05510 J05510 M64699 M64698 U38653 U38812 U38665
PIR	A36579 B36579
RefSeq	NP_001257526.1
UniGene	Rn.2135
PDB	3T8S 3UJ0 3UJ4
PDBsum	3T8S 3UJ0 3UJ4
ProteinModelPortal	P29994
SMR	P29994
BioGrid	247302
DIP	DIP-29715N
IntAct	P29994
MINT	MINT-5026585
BindingDB	P29994
ChEMBL	CHEMBL2804
GuidetoPHARMACOLOGY	743
PhosphoSite	P29994
PaxDb	P29994
PRIDE	P29994
GeneID	25262
KEGG	rno:25262
CTD	3708
RGD	2933
eggNOG	NOG280601
HOGENOM	HOG000007660
HOVERGEN	HBG052158
InParanoid	P29994
KO	K04958
PhylomeDB	P29994
Reactome	REACT_194374 REACT_194690 REACT_203734 REACT_211910 REACT_220575 REACT_221588 REACT_234414 REACT_247187
NextBio	605915
PRO	PR:P29994
Proteomes	UP000002494
Genevestigator	P29994
GO	GO:0005737 GO:0030425 GO:0005789 GO:0016021 GO:0043231 GO:0045121 GO:0043025 GO:0005635 GO:0048471 GO:0005886 GO:0014069 GO:0043234 GO:0016529 GO:0030667 GO:0097060 GO:0005220 GO:0005218 GO:0035091 GO:0008022 GO:0032403 GO:0019903 GO:0071320 GO:0071456 GO:0048016 GO:0070059 GO:1901215 GO:0051928 GO:0007204 GO:0051209
Gene3D	1.25.10.30
InterPro	IPR016024 IPR014821 IPR000493 IPR005821 IPR016093 IPR013662 IPR000699 IPR015925
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF01365
PRINTS	PR00779
SMART	SM00472
SUPFAM	SSF100909 SSF48371 SSF82109
PROSITE	PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:2165071^[1]	ECO:0000314			F		Figure 6 shows that the negative charged amino acid residues represent the calcium channels for which help to to moderate the inositol 1,4,5-triphosphate.	complete CACAO 9309
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:16223735^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11881	F		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0030868) part_of:(GO:0098793) part_of:(UBERON:0000061) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030868	smooth endoplasmic reticulum membrane	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098794) part_of:(UBERON:0000061) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030868	smooth endoplasmic reticulum membrane	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098793) part_of:(UBERON:0000061) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0030868) part_of:(GO:0098794) part_of:(UBERON:0000061) part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0030176	integral component of endoplasmic reticulum membrane	PMID:1311032^[3]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0030868) part_of:(GO:0044425) part_of:(GO:0098793) part_of:(GO:0098982) part_of:(UBERON:0000061) part_of:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:2000347	positive regulation of hepatocyte proliferation	PMID:24814243^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:20434434^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:24814243^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	PMID:12676536^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:17285299^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:20189985^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	PMID:19036964^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:23479737^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12615969^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15911880^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15212990^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21859719^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:28072885^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:17471556^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:12676536^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:15911880^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17471556^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:15212990^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:16014380^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016358	dendrite development	PMID:19236309^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:1338970^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:21211516^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:12676536^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:733700	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:12676536^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:71087	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:24814243^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:15911880^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15911880^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:15911880^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:15533917^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12615969^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:16014380^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:19036964^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:15533917^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185	F		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001010185 RGD:2933 UniProtKB:Q8WN96	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:69649	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96623 MGI:MGI:96624 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:96624 MGI:MGI:99418 PANTHER:PTN001010185 RGD:2933 RGD:2934 RGD:69649 UniProtKB:Q14573	F		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
involved_in	GO:0048016	inositol phosphate-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005220	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493 InterPro:IPR015925	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P		Seeded From UniProt	complete
enables	GO:0070679	inositol 1,4,5 trisphosphate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000493	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26458101^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29994-1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21827954^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P29994-1	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-RNO-182097 Reactome:R-RNO-182052	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0030658	transport vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0245	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mignery, GA et al. (1990) Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 265 12679-85 PubMed GONUTS page
↑ Li, Y et al. (2005) Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. J. Biol. Chem. 280 41298-306 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Takei, K et al. (1992) Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin. J. Neurosci. 12 489-505 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Oliveira, AG et al. (2015) Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration. Liver Int. 35 1162-71 PubMed GONUTS page
↑ Bickler, PE & Fahlman, CS (2010) Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res. 1340 86-95 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Maximov, A et al. (2003) Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Mol. Cell. Neurosci. 22 271-83 PubMed GONUTS page
↑ Jurkovicova, D et al. (2007) Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum. Pflugers Arch. 454 415-25 PubMed GONUTS page
↑ Tovey, SC et al. (2010) Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. J. Biol. Chem. 285 12979-89 PubMed GONUTS page
↑ ^9.0 ^9.1 Chen, X et al. (2008) Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J. Neurosci. 28 12713-24 PubMed GONUTS page
↑ Alzayady, KJ et al. (2013) Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels. J. Biol. Chem. 288 11122-34 PubMed GONUTS page
↑ ^11.0 ^11.1 Vermassen, E et al. (2003) Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells. J. Cell. Sci. 116 1269-77 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Hur, EM et al. (2005) Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. J. Cell Biol. 169 657-67 PubMed GONUTS page
↑ ^13.0 ^13.1 Erin, N & Billingsley, ML (2004) Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices. Brain Res. 1014 45-52 PubMed GONUTS page
↑ Kopil, CM et al. (2011) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. J. Biol. Chem. 286 35998-6010 PubMed GONUTS page
↑ Ikebara, JM et al. (2017) Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia. PLoS ONE 12 e0169861 PubMed GONUTS page
↑ ^16.0 ^16.1 Nicolay, NH et al. (2007) Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. J. Neurosci. Res. 85 2026-36 PubMed GONUTS page
↑ ^17.0 ^17.1 Cárdenas, C et al. (2005) Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation. J. Cell. Sci. 118 3131-40 PubMed GONUTS page
↑ Collado-Hilly, M & Coquil, JF (2009) Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells. Biol. Cell 101 469-80 PubMed GONUTS page
↑ Suzuki, T et al. (1992) P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum. Neurochem. Int. 20 61-7 PubMed GONUTS page
↑ Itoh, K et al. (2011) Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors. Brain Res. 1377 32-40 PubMed GONUTS page
↑ ^21.0 ^21.1 Tu, H et al. (2005) Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms. Biophys. J. 88 1046-55 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 ^22.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Fan, G et al. (2015) Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature 527 336-41 PubMed GONUTS page
↑ Ludtke, SJ et al. (2011) Flexible architecture of IP3R1 by Cryo-EM. Structure 19 1192-9 PubMed GONUTS page

[PMID:2165071-1] Mignery, GA et al. (1990) Structure and expression of the rat inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 265 12679-85 PubMed GONUTS page

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[PMID:15911880-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Hur, EM et al. (2005) Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling. J. Cell Biol. 169 657-67 PubMed GONUTS page

[PMID:15212990-13] 13.0 ^13.1 Erin, N & Billingsley, ML (2004) Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices. Brain Res. 1014 45-52 PubMed GONUTS page

[PMID:21859719-14] Kopil, CM et al. (2011) Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. J. Biol. Chem. 286 35998-6010 PubMed GONUTS page

[PMID:28072885-15] Ikebara, JM et al. (2017) Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia. PLoS ONE 12 e0169861 PubMed GONUTS page

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[PMID:1338970-19] Suzuki, T et al. (1992) P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum. Neurochem. Int. 20 61-7 PubMed GONUTS page

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[PMID:21873635-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 ^22.8 ^22.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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[PMID:21827954-24] Ludtke, SJ et al. (2011) Flexible architecture of IP3R1 by Cryo-EM. Structure 19 1192-9 PubMed GONUTS page

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RAT:ITPR1

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