RAT:INS2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Ins2 (synonyms: Ins-2)
Protein Name(s)	Insulin-2 Insulin-2 B chain Insulin-2 A chain
External Links
UniProt	P01323
EMBL	V01243 J00748 M25585 M25583
PIR	B90789
RefSeq	NP_062003.1
UniGene	Rn.989
ProteinModelPortal	P01323
SMR	P01323
BioGrid	246665
STRING	10116.ENSRNOP00000027656
PhosphoSite	P01323
PaxDb	P01323
PRIDE	P01323
Ensembl	ENSRNOT00000027656
GeneID	24506
KEGG	rno:24506
CTD	16334
RGD	2916
eggNOG	NOG45999
GeneTree	ENSGT00390000015440
HOGENOM	HOG000261669
HOVERGEN	HBG006137
InParanoid	P01323
KO	K04526
OMA	GFFYSPK
OrthoDB	EOG7TF7CG
PhylomeDB	P01323
TreeFam	TF332820
Reactome	REACT_274049 REACT_275576 REACT_276026 REACT_289184 REACT_291993 REACT_295378 REACT_331521 REACT_340889 REACT_345047
NextBio	603523
PMAP-CutDB	P01323
PRO	PR:P01323
Proteomes	UP000002494
Genevisible	P01323
GO	GO:0005615 GO:0005634 GO:0030141 GO:0005732 GO:0002020 GO:0032403 GO:0000187 GO:0060070 GO:0006983 GO:0006006 GO:0070059 GO:0016042 GO:0007520 GO:0000122 GO:0043552 GO:0043393
Gene3D	1.10.100.10
InterPro	IPR004825 IPR016179 IPR022353 IPR022352
Pfam	PF00049
PRINTS	PR00277 PR00276
SMART	SM00078
SUPFAM	SSF56994
PROSITE	PS00262

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005615	extracellular space		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0030141	secretory granule		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0005625	soluble fraction		ECO:0000314			C	Source: RGD	Missing: reference
	GO:0002020	protease binding		ECO:0000021			F	Source: RGD	Missing: with/from, reference
enables	GO:0044877	protein-containing complex binding	PMID:10806118^[1]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3272 RGD:621314	F	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:10806118^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0030141	secretory granule	PMID:7822759^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0030141	secretory granule	PMID:10806118^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008150	biological_process	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12475375^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:10806118^[1]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3272	F	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000155760 RGD:2915	P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760 RGD:2915	C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000155760 RGD:2915	F	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96573 PANTHER:PTN000155760	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0060070	canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	C	Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0014902	myotube differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0007520	myoblast fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0006983	ER overload response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	C	Seeded From UniProt	complete
part_of	GO:0005732	small nucleolar ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	C	Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01326 ensembl:ENSMUSP00000147425	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179 InterPro:IPR022352	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004825 InterPro:IPR016179	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Arias, AE et al. (2000) Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. J. Cell. Sci. 113 ( Pt 11) 2075-83 PubMed GONUTS page
↑ Malide, D et al. (1995) Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. J. Histochem. Cytochem. 43 11-9 PubMed GONUTS page
↑ Guest, PC et al. (2002) Proinsulin processing in the diabetic Goto-Kakizaki rat. J. Endocrinol. 175 637-47 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10806118-1] 1.0 ^1.1 ^1.2 ^1.3 Arias, AE et al. (2000) Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. J. Cell. Sci. 113 ( Pt 11) 2075-83 PubMed GONUTS page

[PMID:7822759-2] Malide, D et al. (1995) Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. J. Histochem. Cytochem. 43 11-9 PubMed GONUTS page

[PMID:12475375-3] Guest, PC et al. (2002) Proinsulin processing in the diabetic Goto-Kakizaki rat. J. Endocrinol. 175 637-47 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:INS2

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Notes

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