RAT:D4A523

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	No Information Provided.
Protein Name(s)	Protein Nlrp3 (ECO:0000313 with Ensembl:ENSRNOP00000004280)
External Links
UniProt	D4A523
EMBL	AABR06064074 AABR06064075
RefSeq	NP_001178571.1 XP_006246515.1
UniGene	Rn.214177
ProteinModelPortal	D4A523
Ensembl	ENSRNOT00000004280
GeneID	287362
KEGG	rno:287362
UCSC	RGD:1308314
CTD	114548
RGD	1308314
GeneTree	ENSGT00770000120466
InParanoid	D4A523
KO	K12800
OMA	EVDCERF
OrthoDB	EOG7P5T07
Reactome	REACT_196450
NextBio	35572564
PRO	PR:D4A523
Proteomes	UP000002494
GO	GO:0072559 GO:0005524 GO:0006919 GO:0071222 GO:0051607 GO:0006954 GO:0032611 GO:0050701 GO:0032621 GO:0002674 GO:0050713 GO:0042347 GO:0032088 GO:0044546 GO:0050718 GO:0051092
Gene3D	1.10.533.10
InterPro	IPR004020 IPR011029 IPR001611 IPR003590 IPR007111 IPR029495 IPR027417
Pfam	PF14484 PF02758
SMART	SM00368
SUPFAM	SSF47986 SSF52540
PROSITE	PS50824 PS51450 PS50837

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050701	interleukin-1 secretion	PMID:24454932^[1]	ECO:0000314			P	Figures 6A-C: NLRP3 impaired early renal IL1-β levels after UUO.	complete CACAO 9435
involved_in	GO:0008150	biological_process	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005575	cellular_component	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648032 UniProtKB:Q96P20	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2653833 PANTHER:PTN000648032 UniProtKB:Q96P20	P	Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648032 UniProtKB:Q96P20	P	Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:2000321	positive regulation of T-helper 17 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
part_of	GO:0072559	NLRP3 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	C	Seeded From UniProt	complete
involved_in	GO:0071224	cellular response to peptidoglycan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0050701	interleukin-1 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0045630	positive regulation of T-helper 2 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0044546	NLRP3 inflammasome complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	F	Seeded From UniProt	complete
involved_in	GO:0032754	positive regulation of interleukin-5 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0032736	positive regulation of interleukin-13 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0032621	interleukin-18 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0032611	interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	F	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	C	Seeded From UniProt	complete
involved_in	GO:0002830	positive regulation of type 2 immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:0002374	cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R4B8 ensembl:ENSMUSP00000098707	P	Seeded From UniProt	complete
involved_in	GO:1901223	negative regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
part_of	GO:0072559	NLRP3 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	C	Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0050713	negative regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	F	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	C	Seeded From UniProt	complete
involved_in	GO:0002674	negative regulation of acute inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	P	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96P20 ensembl:ENSP00000337383	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0061702	inflammasome complex	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1271 UniProtKB-SubCell:SL-0488	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Pulskens, WP et al. (2014) Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction. PLoS ONE 9 e85775 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24454932-1] Pulskens, WP et al. (2014) Nlrp3 prevents early renal interstitial edema and vascular permeability in unilateral ureteral obstruction. PLoS ONE 9 e85775 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:D4A523

Contents

Annotations

Notes

References

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