RAT:CD44

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cd44
Protein Name(s)	CD44 antigen Extracellular matrix receptor III ECMR-III GP90 lymphocyte homing/adhesion receptor HUTCH-I Hermes antigen Hyaluronate receptor Phagocytic glycoprotein 1 PGP-1 Phagocytic glycoprotein I PGP-I
External Links
UniProt	P26051
EMBL	M61875 M61874 U52179 U46957
PIR	B38745
RefSeq	XP_006234693.1
UniGene	Rn.1120
ProteinModelPortal	P26051
SMR	P26051
IntAct	P26051
PhosphoSite	P26051
PaxDb	P26051
PRIDE	P26051
GeneID	25406
KEGG	rno:25406
UCSC	RGD:2307
CTD	960
RGD	2307
eggNOG	NOG41023
HOVERGEN	HBG003850
InParanoid	P26051
KO	K06256
PhylomeDB	P26051
PRO	PR:P26051
Proteomes	UP000002494
Genevestigator	P26051
GO	GO:0016324 GO:0016323 GO:0016021 GO:0005634 GO:0043234 GO:0005154 GO:0005540 GO:0051219 GO:0019901 GO:0001955 GO:0007155 GO:0016477 GO:0006954 GO:0034238 GO:0031175 GO:0033031 GO:0001558 GO:0014070 GO:0033189
Gene3D	3.10.100.10
InterPro	IPR016186 IPR016187 IPR001231 IPR000538
Pfam	PF00193
PRINTS	PR00658 PR01265
SMART	SM00445
SUPFAM	SSF56436
PROSITE	PS01241 PS50963

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005902	microvillus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15379	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16070	C	Seeded From UniProt	complete
part_of	GO:0031258	lamellipodium membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16070	C	Seeded From UniProt	complete
involved_in	GO:2000392	regulation of lamellipodium morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16070	P	Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16070	P	Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:11316791^[1]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:3169	F	Seeded From UniProt	complete
involved_in	GO:0034238	macrophage fusion	PMID:16195325^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	PMID:16804311^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033031	positive regulation of neutrophil apoptotic process	PMID:11044212^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11316791^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	PMID:17760872^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8103744^[6]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2641	F	Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:16306150^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:16786159^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:16786159^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:17105903^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:16306150^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:1707342^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:8639178^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16195325^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	PMID:21349584^[12]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2543	F	Seeded From UniProt	complete
involved_in	GO:0001955	blood vessel maturation	PMID:15947460^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001558	regulation of cell growth	PMID:11316791^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88338 PANTHER:PTN000027499 UniProtKB:P16070	P	Seeded From UniProt	complete
part_of	GO:0035692	macrophage migration inhibitory factor receptor complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88338 PANTHER:PTN000027499 UniProtKB:P16070	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88338 PANTHER:PTN000027499 RGD:2307 UniProtKB:F1SGT4	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88338 PANTHER:PTN000027499 RGD:2307	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000027499 RGD:2307	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2136348 MGI:MGI:88338 PANTHER:PTN000812484 UniProtKB:F1SGT4 UniProtKB:P16070	C	Seeded From UniProt	complete
enables	GO:0005540	hyaluronic acid binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2136348 MGI:MGI:88338 PANTHER:PTN000812485 UniProtKB:P16070	F	Seeded From UniProt	complete
contributes_to	GO:0004896	cytokine receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88338 PANTHER:PTN000027499 UniProtKB:P16070	F	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2136348 PANTHER:PTN000812484	F	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004896	P	Seeded From UniProt	complete
enables	GO:0005540	hyaluronic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000538	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000538 InterPro:IPR001231	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001231	C	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0293	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Morrison, H et al. (2001) The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev. 15 968-80 PubMed GONUTS page
↑ ^2.0 ^2.1 Cui, W et al. (2006) The intracellular domain of CD44 promotes the fusion of macrophages. Blood 107 796-805 PubMed GONUTS page
↑ Sen, M et al. (2006) Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. Eur Surg Res 38 347-52 PubMed GONUTS page
↑ Takazoe, K et al. (2000) CD44-mediated neutrophil apoptosis in the rat. Kidney Int. 58 1920-30 PubMed GONUTS page
↑ Ries, A et al. (2007) A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach. J. Neurochem. 103 1491-505 PubMed GONUTS page
↑ Carmo, AM et al. (1993) Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn. Eur. J. Immunol. 23 2196-201 PubMed GONUTS page
↑ ^7.0 ^7.1 Zhu, H et al. (2006) The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells 24 928-35 PubMed GONUTS page
↑ ^8.0 ^8.1 Declèves, AE et al. (2006) Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury. Int. J. Mol. Med. 18 83-94 PubMed GONUTS page
↑ Adriani, W et al. (2006) Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Ann. N. Y. Acad. Sci. 1074 52-73 PubMed GONUTS page
↑ Günthert, U et al. (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65 13-24 PubMed GONUTS page
↑ Halloran, MM et al. (1996) Cellular adhesion molecules in rat adjuvant arthritis. Arthritis Rheum. 39 810-9 PubMed GONUTS page
↑ Kim, Y et al. (2011) Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis. Mol. Immunol. 48 1035-45 PubMed GONUTS page
↑ Hellström, M et al. (2005) Expression of the CD44 receptor in the blood vessel system: an experimental study in rat. Cells Tissues Organs (Print) 179 102-8 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11316791-1] 1.0 ^1.1 ^1.2 Morrison, H et al. (2001) The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev. 15 968-80 PubMed GONUTS page

[PMID:16195325-2] 2.0 ^2.1 Cui, W et al. (2006) The intracellular domain of CD44 promotes the fusion of macrophages. Blood 107 796-805 PubMed GONUTS page

[PMID:16804311-3] Sen, M et al. (2006) Effect of vitamin A on the CD44 expression in the small intestine of rats with obstructive jaundice. Eur Surg Res 38 347-52 PubMed GONUTS page

[PMID:11044212-4] Takazoe, K et al. (2000) CD44-mediated neutrophil apoptosis in the rat. Kidney Int. 58 1920-30 PubMed GONUTS page

[PMID:17760872-5] Ries, A et al. (2007) A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach. J. Neurochem. 103 1491-505 PubMed GONUTS page

[PMID:8103744-6] Carmo, AM et al. (1993) Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn. Eur. J. Immunol. 23 2196-201 PubMed GONUTS page

[PMID:16306150-7] 7.0 ^7.1 Zhu, H et al. (2006) The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells 24 928-35 PubMed GONUTS page

[PMID:16786159-8] 8.0 ^8.1 Declèves, AE et al. (2006) Dynamics of hyaluronan, CD44, and inflammatory cells in the rat kidney after ischemia/reperfusion injury. Int. J. Mol. Med. 18 83-94 PubMed GONUTS page

[PMID:17105903-9] Adriani, W et al. (2006) Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Ann. N. Y. Acad. Sci. 1074 52-73 PubMed GONUTS page

[PMID:1707342-10] Günthert, U et al. (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65 13-24 PubMed GONUTS page

[PMID:8639178-11] Halloran, MM et al. (1996) Cellular adhesion molecules in rat adjuvant arthritis. Arthritis Rheum. 39 810-9 PubMed GONUTS page

[PMID:21349584-12] Kim, Y et al. (2011) Integrin α(5) interacts with EGFR, is necessary for FcɛRI signaling and is necessary for allergic inflammation in relation with angiogenesis. Mol. Immunol. 48 1035-45 PubMed GONUTS page

[PMID:15947460-13] Hellström, M et al. (2005) Expression of the CD44 receptor in the blood vessel system: an experimental study in rat. Cells Tissues Organs (Print) 179 102-8 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:CD44

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