RAT:CCKN

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Cck
Protein Name(s)	Cholecystokinin CCK Cholecystokinin-39 CCK39 Cholecystokinin-33 CCK33 Cholecystokinin-22 CCK22 Cholecystokinin-12 CCK12 Cholecystokinin-8 CCK8
External Links
UniProt	P01355
EMBL	X01032 K01259 M25942 M10353 M10352
PIR	A01624
RefSeq	NP_036961.1
UniGene	Rn.9781
ProteinModelPortal	P01355
STRING	10116.ENSRNOP00000026159
BindingDB	P01355
PaxDb	P01355
PRIDE	P01355
Ensembl	ENSRNOT00000026159
GeneID	25298
KEGG	rno:25298
UCSC	RGD:2288
CTD	885
RGD	2288
eggNOG	NOG40485
GeneTree	ENSGT00390000003571
HOGENOM	HOG000073533
HOVERGEN	HBG005806
InParanoid	P01355
KO	K05226
OMA	MPHADPT
OrthoDB	EOG7F7WBS
PhylomeDB	P01355
TreeFam	TF333419
Reactome	REACT_250028 REACT_263374
NextBio	606067
PMAP-CutDB	P01355
PRO	PR:P01355
Proteomes	UP000002494
Genevestigator	P01355
GO	GO:0030424 GO:0043203 GO:0043194 GO:0030425 GO:0005576 GO:0005615 GO:0043025 GO:0043204 GO:0043195 GO:0005179 GO:0005184 GO:0006919 GO:0006915 GO:0007409 GO:0001662 GO:0042755 GO:0032099 GO:0001764 GO:0043065 GO:0008284 GO:0051901 GO:0050731 GO:0032461 GO:0007205 GO:0051930 GO:0001836
InterPro	IPR015499 IPR001651 IPR013152
PANTHER	PTHR10786
Pfam	PF00918
SMART	SM00029
PROSITE	PS00259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0014049	positive regulation of glutamate secretion	PMID:20392936^[1]	ECO:0000314			P	Fig 5 shows that CCK increases glutamate release through inhibition of calcium channels.	complete CACAO 6370
involved_in	GO:0014049	positive regulation of glutamate secretion	PMID:20392936^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:15374756^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	C	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:15374756^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	F	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:15152034^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09240	P	Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	PMID:12373548^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000986	negative regulation of behavioral fear response	PMID:12450740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904058	positive regulation of sensory perception of pain	PMID:15647484^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903999	negative regulation of eating behavior	PMID:6185005^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:17157334^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051901	positive regulation of mitochondrial depolarization	PMID:11964411^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:12496267^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:12763251^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	PMID:12763251^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:12763251^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043194	axon initial segment	PMID:12763251^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11964411^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12927199^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	PMID:15890776^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:12496267^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	PMID:12615048^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:12927199^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008542	visual learning	PMID:12450740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15536283^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:12450740^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	PMID:12496267^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:11964411^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:11964411^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8208365^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11964411^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:15647484^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:15890776^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:11964411^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:11964411^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88297 PANTHER:PTN002583982	C	Seeded From UniProt	complete
involved_in	GO:0007586	digestion	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 UniProtKB:Q9PU41	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 RGD:2288 UniProtKB:F1MC79 UniProtKB:P41520	C	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88297 PANTHER:PTN002583982 RGD:2288	F	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002583982 RGD:2288	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005184	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06307 ensembl:ENSP00000379472	F	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	C	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
enables	GO:0005184	neuropeptide hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	F	Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09240 ensembl:ENSMUSP00000149679	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001651	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001651	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Deng, PY et al. (2010) Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J. Neurosci. 30 5136-48 PubMed GONUTS page
↑ ^2.0 ^2.1 Hnasko, TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023 309-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Giacobini, P et al. (2004) Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J. Neurosci. 24 4737-48 PubMed GONUTS page
↑ Hernandez-Gómez, AM et al. (2002) Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. Amino Acids 23 283-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Cohen, H et al. (2002) Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress. Neuropeptides 36 341-52 PubMed GONUTS page
↑ ^6.0 ^6.1 Xie, JY et al. (2005) Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. J. Neurosci. 25 409-16 PubMed GONUTS page
↑ McLaughlin, CL et al. (1983) Hyperphagia during lactation: satiety response to CCK and growth of the pancreas. Am. J. Physiol. 244 E61-5 PubMed GONUTS page
↑ Torres-López, JE et al. (2007) Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats. Neuropharmacology 52 788-95 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gukovskaya, AS et al. (2002) Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J. Biol. Chem. 277 22595-604 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Piiper, A et al. (2003) Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. J. Biol. Chem. 278 7065-72 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Mascagni, F & McDonald, AJ (2003) Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. Brain Res. 976 171-84 PubMed GONUTS page
↑ ^12.0 ^12.1 Morozov, YM & Freund, TF (2003) Postnatal development and migration of cholecystokinin-immunoreactive interneurons in rat hippocampus. Neuroscience 120 923-39 PubMed GONUTS page
↑ ^13.0 ^13.1 Date, Y et al. (2005) Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 146 3518-25 PubMed GONUTS page
↑ Gay, J et al. (2003) Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats. Brain Behav. Immun. 17 35-42 PubMed GONUTS page
↑ Kuntz, E et al. (2004) Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. JOP 5 464-75 PubMed GONUTS page
↑ Beinfeld, MC (1994) Inhibition of pro-cholecystokinin (CCK) sulfation by treatment with sodium chlorate alters its processing and decreases cellular content and secretion of CCK 8. Neuropeptides 26 195-200 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20392936-1] 1.0 ^1.1 Deng, PY et al. (2010) Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability. J. Neurosci. 30 5136-48 PubMed GONUTS page

[PMID:15374756-2] 2.0 ^2.1 Hnasko, TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023 309-18 PubMed GONUTS page

[PMID:15152034-3] 3.0 ^3.1 ^3.2 Giacobini, P et al. (2004) Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons. J. Neurosci. 24 4737-48 PubMed GONUTS page

[PMID:12373548-4] Hernandez-Gómez, AM et al. (2002) Role of cholecystokinin-A and cholecystokinin-B receptors in anxiety. Amino Acids 23 283-90 PubMed GONUTS page

[PMID:12450740-5] 5.0 ^5.1 ^5.2 Cohen, H et al. (2002) Effect of intraperitoneal mRNA antisense-oligodeoxynucleotides to cholecystokinin on anxiety-like and learning behaviors in rats: association with pre-experimental stress. Neuropeptides 36 341-52 PubMed GONUTS page

[PMID:15647484-6] 6.0 ^6.1 Xie, JY et al. (2005) Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. J. Neurosci. 25 409-16 PubMed GONUTS page

[PMID:6185005-7] McLaughlin, CL et al. (1983) Hyperphagia during lactation: satiety response to CCK and growth of the pancreas. Am. J. Physiol. 244 E61-5 PubMed GONUTS page

[PMID:17157334-8] Torres-López, JE et al. (2007) Peripheral participation of cholecystokinin in the morphine-induced peripheral antinociceptive effect in non-diabetic and diabetic rats. Neuropharmacology 52 788-95 PubMed GONUTS page

[PMID:11964411-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 Gukovskaya, AS et al. (2002) Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J. Biol. Chem. 277 22595-604 PubMed GONUTS page

[PMID:12496267-10] 10.0 ^10.1 ^10.2 Piiper, A et al. (2003) Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon. J. Biol. Chem. 278 7065-72 PubMed GONUTS page

[PMID:12763251-11] 11.0 ^11.1 ^11.2 ^11.3 Mascagni, F & McDonald, AJ (2003) Immunohistochemical characterization of cholecystokinin containing neurons in the rat basolateral amygdala. Brain Res. 976 171-84 PubMed GONUTS page

[PMID:12927199-12] 12.0 ^12.1 Morozov, YM & Freund, TF (2003) Postnatal development and migration of cholecystokinin-immunoreactive interneurons in rat hippocampus. Neuroscience 120 923-39 PubMed GONUTS page

[PMID:15890776-13] 13.0 ^13.1 Date, Y et al. (2005) Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 146 3518-25 PubMed GONUTS page

[PMID:12615048-14] Gay, J et al. (2003) Alteration of CCK-induced satiety in post-Nippostrongylus brasiliensis-infected rats. Brain Behav. Immun. 17 35-42 PubMed GONUTS page

[PMID:15536283-15] Kuntz, E et al. (2004) Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. JOP 5 464-75 PubMed GONUTS page

[PMID:8208365-16] Beinfeld, MC (1994) Inhibition of pro-cholecystokinin (CCK) sulfation by treatment with sodium chlorate alters its processing and decreases cellular content and secretion of CCK 8. Neuropeptides 26 195-200 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:CCKN

Contents

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Notes

References

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