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PMID:15374756
| Citation |
Hnasko, TS, Szczypka, MS, Alaynick, WA, During, MJ and Palmiter, RD (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res. 1023:309-18 |
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| Abstract |
Dopamine-deficient (DD) mice become hypophagic and die of starvation by 3 to 4 weeks of age unless dopamine is restored by daily treatment with l-3-4-dihydroxyphenylalanine (l-dopa). We demonstrate here that DD mice mount qualitatively normal counter-regulatory blood glucose responses to insulin and 2-deoxy-d-glucose (2-DG). However, unlike control mice, DD mice fail to eat in response to acute glucoprivation induced by insulin or 2-DG. They also have a severely blunted response to central administration of peptide YY (PYY). Viral-mediated restoration of dopamine synthesis to the central caudate putamen (CPu) of DD mice rescues feeding and survival. However, this treatment fails to restore insulin- and 2-DG-induced feeding despite normalizing feeding in response to food deprivation and PYY. Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region. |
| Links |
PubMed Online version:10.1016/j.brainres.2004.07.051 |
| Keywords |
Adenoviridae/physiology; Analysis of Variance; Animals; Antimetabolites/pharmacology; Behavior, Animal; Blood Glucose/metabolism; Deoxyglucose/pharmacology; Dopamine/physiology; Dopamine Agents/pharmacology; Dopamine beta-Hydroxylase/deficiency; Dopamine beta-Hydroxylase/genetics; Drug Interactions; Eating/drug effects; Eating/physiology; Feeding Behavior/drug effects; Feeding Behavior/physiology; Food Deprivation; Genetic Vectors; Hypoglycemic Agents/pharmacology; Insulin/pharmacology; Levodopa/pharmacology; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide YY/pharmacology; Sincalide/administration & dosage; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase/deficiency; Tyrosine 3-Monooxygenase/genetics |
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Significance
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| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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