RAT:BCL2

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Bcl2 (synonyms: Bcl-2)
Protein Name(s)	Apoptosis regulator Bcl-2
External Links
UniProt	P49950
EMBL	L14680 U34964 S74122
PIR	I53744 I67432
RefSeq	NP_058689.1
UniGene	Rn.9996
ProteinModelPortal	P49950
SMR	P49950
BioGrid	246412
DIP	DIP-30849N
IntAct	P49950
STRING	10116.ENSRNOP00000003768
iPTMnet	P49950
PhosphoSitePlus	P49950
PaxDb	P49950
GeneID	24224
KEGG	rno:24224
UCSC	RGD:2199
CTD	596
RGD	2199
eggNOG	KOG4728 ENOG41123S0
HOGENOM	HOG000056452
HOVERGEN	HBG004472
InParanoid	P49950
KO	K02161
PhylomeDB	P49950
PRO	PR:P49950
Proteomes	UP000002494
GO	GO:0005737 GO:0005829 GO:0005789 GO:0016021 GO:0005741 GO:0005739 GO:0031965 GO:0048471 GO:0051400 GO:0046982 GO:0007568 GO:0006915 GO:0007420 GO:1902618 GO:0071333 GO:0071456 GO:0071407 GO:0021987 GO:0034349 GO:0097421 GO:0043066 GO:0048709 GO:0001541 GO:0046902 GO:0051881 GO:0001836 GO:0010044 GO:1904645 GO:0031000 GO:0051591 GO:0046688 GO:0051412 GO:0034097 GO:0042493 GO:0051602 GO:0036017 GO:0043627 GO:0045471 GO:0051593 GO:0009408 GO:0001666 GO:0010035 GO:0032868 GO:0033591 GO:0034284 GO:0035094 GO:0007584 GO:0014070 GO:0010033 GO:0043434 GO:0080184 GO:0033197
InterPro	IPR013278 IPR002475 IPR004725 IPR020717 IPR020726 IPR020728 IPR003093 IPR020731 IPR026298
PANTHER	PTHR11256 PTHR11256:SF55
Pfam	PF00452 PF02180
PRINTS	PR01863 PR01862
SMART	SM00265
TIGRFAMs	TIGR00865
PROSITE	PS50062 PS01080 PS01258 PS01259 PS01260 PS50063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030061	mitochondrial crista	PMID:9731187^[1]	ECO:0000314			C	Figure 6 clearly illustrates that Bcl-2 is predominantly localized in the crista of the Mitochondria. Uniprot Nomenclature: Apoptosis regulator Bcl-2 (BCL2_RAT) Uniprot ID: P49950 Organism: Rattus norvegicus	complete CACAO 12583
	GO:0005743	mitochondrial inner membrane	PMID:9731187^[1]	ECO:0000314			C	Figure 6 clearly illustrates that Bcl-2 is predominantly localized in the inner mitochondrial membrane. Uniprot Nomenclature: Apoptosis regulator Bcl-2 (BCL2_RAT) Uniprot ID: P49950 Organism: Rattus norvegicus	complete CACAO 12584
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	PMID:26692938^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21212266^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:9843949^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P	Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:9843949^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P	Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:9843949^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	PMID:18374914^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902618	cellular response to fluoride	PMID:16388103^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:21503946^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0080184	response to phenylpropanoid	PMID:22700048^[8]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20669351^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:19574995^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:21474815^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	PMID:17700647^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051593	response to folic acid	PMID:18156304^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	PMID:18086876^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051412	response to corticosterone	PMID:17562391^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621635	F	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621547	F	Seeded From UniProt	complete
enables	GO:0051400	BH domain binding	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2192	F	Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:12787069^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:11299004^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621635	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:621547	F	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9356461^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2192	F	Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	PMID:18289470^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:18259862^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:15469889^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:16084662^[22]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:15686664^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15004018^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11879647^[25]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18284815^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036017	response to erythropoietin	PMID:26261574^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:15332118^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	PMID:18931364^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034284	response to monosaccharide	PMID:26261574^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:18832793^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033591	response to L-ascorbic acid	PMID:18758938^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	PMID:26261574^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:18758938^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	PMID:17236787^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	PMID:9813151^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18384965^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010044	response to aluminum ion	PMID:17967740^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	PMID:16256253^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:16249675^[37]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:17131910^[38]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	PMID:16216918^[39]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:9813151^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:17302035^[40]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:18058945^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:18959742^[42]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18259862^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:15341589^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15341589^[43]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16445580^[44]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	PMID:17570453^[45]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[46]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004725	C	Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003093 InterPro:IPR004725 InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR020731 InterPro:IPR026298 InterPro:IPR036834	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013278	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:11792651^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Motoyama, S et al. (1998) Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Biochem. Biophys. Res. Commun. 249 628-36 PubMed GONUTS page
↑ Zhai, C et al. (2015) Inhibition of microRNA-1 attenuates hypoxia/re-oxygenation-induced apoptosis of cardiomyocytes by directly targeting Bcl-2 but not GADD45Beta. Am J Transl Res 7 1952-62 PubMed GONUTS page
↑ Dluzen, D et al. (2011) BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J. Biol. Chem. 286 7705-13 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page
↑ Chi, CW et al. (2008) Tournefolic acid B attenuates amyloid beta protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons. Eur. J. Pharmacol. 586 35-43 PubMed GONUTS page
↑ Xu, H et al. (2006) Effect of sodium fluoride on the expression of bcl-2 family and osteopontin in rat renal tubular cells. Biol Trace Elem Res 109 55-60 PubMed GONUTS page
↑ Guerra, MT et al. (2011) Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis. Hepatology 54 296-306 PubMed GONUTS page
↑ Jian, J et al. (2012) The effect of 17-methoxyl-7-hydroxy-benzene-furanchalcone isolated from Millettia pulchra on myocardial ischemia in vitro and in vivo. Planta Med. 78 1324-31 PubMed GONUTS page
↑ Gao, F et al. (2010) Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. J Zhejiang Univ Sci B 11 608-17 PubMed GONUTS page
↑ Liu, RT et al. (2009) Liquiritigenin inhibits Abeta(25-35)-induced neurotoxicity and secretion of Abeta(1-40) in rat hippocampal neurons. Acta Pharmacol. Sin. 30 899-906 PubMed GONUTS page
↑ Katare, R et al. (2011) Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ. Res. 108 1238-51 PubMed GONUTS page
↑ Kosten, TA et al. (2008) Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures. Neuropsychopharmacology 33 1545-58 PubMed GONUTS page
↑ Marsillach, J et al. (2008) Moderately high folic acid supplementation exacerbates experimentally induced liver fibrosis in rats. Exp. Biol. Med. (Maywood) 233 38-47 PubMed GONUTS page
↑ Kim, SJ et al. (2008) Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol. Cell. Biol. 28 1644-56 PubMed GONUTS page
↑ Yoshimura, A et al. (2007) Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure. Brain Res. Bull. 73 254-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Hsu, SY et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U.S.A. 94 12401-6 PubMed GONUTS page
↑ Itoh, T et al. (2003) Bcl-2-related protein family gene expression during oligodendroglial differentiation. J. Neurochem. 85 1500-12 PubMed GONUTS page
↑ Vis, JC et al. (2001) The mitochondrial toxin 3-nitropropionic acid induces differential expression patterns of apoptosis-related markers in rat striatum. Neuropathol. Appl. Neurobiol. 27 68-76 PubMed GONUTS page
↑ Li, YW et al. (2008) [Excessive copper induces hepatocyte apoptosis and affects Bax and Bcl-2 expression in rat liver]. Zhongguo Dang Dai Er Ke Za Zhi 10 42-6 PubMed GONUTS page
↑ ^20.0 ^20.1 Bhupanapadu Sunkesula, SR et al. (2008) Cell death is associated with reduced base excision repair during chronic alcohol administration in adult rat brain. Neurochem. Res. 33 1117-28 PubMed GONUTS page
↑ Ge, Y et al. (2004) Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9. Brain Res. Mol. Brain Res. 129 124-34 PubMed GONUTS page
↑ Wu, TW et al. (2005) 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuroprotection. Neuroscience 135 59-72 PubMed GONUTS page
↑ Emir, M et al. (2004) Effect of erythropoietin on bcl-2 gene expression in rat cardiac myocytes after traumatic brain injury. Transplant. Proc. 36 2935-8 PubMed GONUTS page
↑ Wang, J et al. (2004) Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J. Biol. Chem. 279 19948-54 PubMed GONUTS page
↑ Goldberg, JL et al. (2002) Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron 33 689-702 PubMed GONUTS page
↑ Yiming, L et al. (2008) Neuroprotective effects of breviscapine against apoptosis induced by transient focal cerebral ischaemia in rats. J. Pharm. Pharmacol. 60 349-55 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Wu, H et al. (2015) rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1. Int J Clin Exp Pathol 8 6870-80 PubMed GONUTS page
↑ Sun, X et al. (2004) Protective effects of nicotine against glutamate-induced neurotoxicity in PC12 cells. Cell. Mol. Biol. Lett. 9 409-22 PubMed GONUTS page
↑ Bhattacharjee, M et al. (2008) Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Int. Immunol. 20 1489-505 PubMed GONUTS page
↑ Lan, X et al. (2008) Granulocyte-colony stimulating factor inhibits neuronal apoptosis in a rat model of diabetic cerebral ischemia. Tohoku J. Exp. Med. 216 117-26 PubMed GONUTS page
↑ ^31.0 ^31.1 Jafari Anarkooli, I et al. (2009) Evaluation of insulin and ascorbic acid effects on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of STZ-induced diabetic rats. Cell. Mol. Neurobiol. 29 133-40 PubMed GONUTS page
↑ Corsetti, G et al. (2007) Acute caffeine administration decreased NOS and Bcl2 expression in rat skeletal muscles. Pharmacol. Res. 55 96-103 PubMed GONUTS page
↑ ^33.0 ^33.1 Shimohama, S et al. (1998) Differential expression of rat brain bcl-2 family proteins in development and aging. Biochem. Biophys. Res. Commun. 252 92-6 PubMed GONUTS page
↑ Yamagata, K et al. (2008) Protective effects of ebselen, a seleno-organic antioxidant on neurodegeneration induced by hypoxia and reperfusion in stroke-prone spontaneously hypertensive rat. Neuroscience 153 428-35 PubMed GONUTS page
↑ Niu, Q et al. (2007) The relationship between Bcl-gene expression and learning and memory impairment in chronic aluminum-exposed rats. Neurotox Res 12 163-9 PubMed GONUTS page
↑ Bai, J & Meng, Z (2005) Effects of sulfur dioxide on apoptosis-related gene expressions in lungs from rats. Regul. Toxicol. Pharmacol. 43 272-9 PubMed GONUTS page
↑ Jamnicki-Abegg, M et al. (2005) Isoflurane inhibits cardiac myocyte apoptosis during oxidative and inflammatory stress by activating Akt and enhancing Bcl-2 expression. Anesthesiology 103 1006-14 PubMed GONUTS page
↑ Khar, A et al. (2006) Heat stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species. Indian J. Exp. Biol. 44 802-8 PubMed GONUTS page
↑ Jeyakumar, SM et al. (2005) Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. J. Mol. Endocrinol. 35 391-8 PubMed GONUTS page
↑ Zhang, ZB et al. (2007) [Lipid peroxidation affects serum T and Bcl-2 expression in the testis of aging male rats]. Zhonghua Nan Ke Xue 13 46-9 PubMed GONUTS page
↑ Soane, L et al. (2008) Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res. 86 1267-76 PubMed GONUTS page
↑ Onoue, S et al. (2008) Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J. 275 5542-51 PubMed GONUTS page
↑ ^43.0 ^43.1 Hu, XL et al. (2004) Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Eur. J. Neurosci. 20 1177-88 PubMed GONUTS page
↑ Ma, XQ et al. (2005) Hypoxia-reoxygenation-induced apoptosis in cultured neonatal rat cardiomyocyets and the protective effect of prostaglandin E. Clin. Exp. Pharmacol. Physiol. 32 1124-30 PubMed GONUTS page
↑ Gürsoy, E et al. (2008) Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Res. Vet. Sci. 84 56-61 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 ^46.3 ^46.4 ^46.5 ^46.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Phaneuf, S & Leeuwenburgh, C (2002) Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 R423-30 PubMed GONUTS page

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[PMID:17131910-38] Khar, A et al. (2006) Heat stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species. Indian J. Exp. Biol. 44 802-8 PubMed GONUTS page

[PMID:16216918-39] Jeyakumar, SM et al. (2005) Vitamin A supplementation induces adipose tissue loss through apoptosis in lean but not in obese rats of the WNIN/Ob strain. J. Mol. Endocrinol. 35 391-8 PubMed GONUTS page

[PMID:17302035-40] Zhang, ZB et al. (2007) [Lipid peroxidation affects serum T and Bcl-2 expression in the testis of aging male rats]. Zhonghua Nan Ke Xue 13 46-9 PubMed GONUTS page

[PMID:18058945-41] Soane, L et al. (2008) Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. J. Neurosci. Res. 86 1267-76 PubMed GONUTS page

[PMID:18959742-42] Onoue, S et al. (2008) Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J. 275 5542-51 PubMed GONUTS page

[PMID:15341589-43] 43.0 ^43.1 Hu, XL et al. (2004) Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats. Eur. J. Neurosci. 20 1177-88 PubMed GONUTS page

[PMID:16445580-44] Ma, XQ et al. (2005) Hypoxia-reoxygenation-induced apoptosis in cultured neonatal rat cardiomyocyets and the protective effect of prostaglandin E. Clin. Exp. Pharmacol. Physiol. 32 1124-30 PubMed GONUTS page

[PMID:17570453-45] Gürsoy, E et al. (2008) Expression and localisation of Bcl-2 and Bax proteins in developing rat ovary. Res. Vet. Sci. 84 56-61 PubMed GONUTS page

[PMID:21873635-46] 46.0 ^46.1 ^46.2 ^46.3 ^46.4 ^46.5 ^46.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11792651-47] Phaneuf, S & Leeuwenburgh, C (2002) Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 R423-30 PubMed GONUTS page

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