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RAT:AQP2

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Aqp2
Protein Name(s) Aquaporin-2

AQP-2 ADH water channel Aquaporin-CD AQP-CD Collecting duct water channel protein WCH-CD Water channel protein for renal collecting duct

External Links
UniProt P34080
EMBL D13906
L28112
BC128705
PIR JT0750
RefSeq NP_037041.2
UniGene Rn.90076
ProteinModelPortal P34080
SMR P34080
DIP DIP-46223N
STRING 10116.ENSRNOP00000000324
PhosphoSite P34080
PaxDb P34080
Ensembl ENSRNOT00000000324
GeneID 25386
KEGG rno:25386
UCSC RGD:2142
CTD 359
RGD 2142
eggNOG COG0580
GeneTree ENSGT00760000119223
HOGENOM HOG000288286
HOVERGEN HBG000312
InParanoid P34080
KO K09865
OrthoDB EOG7N8ZWD
PhylomeDB P34080
TreeFam TF312940
Reactome REACT_230689
REACT_259181
NextBio 606439
PRO PR:P34080
Proteomes UP000002494
Genevestigator P34080
GO GO:0016324
GO:0016323
GO:0030136
GO:0005737
GO:0030659
GO:0005769
GO:0070382
GO:0070062
GO:0016021
GO:0005764
GO:0005886
GO:0043234
GO:0055037
GO:0005791
GO:0005802
GO:0030133
GO:0003779
GO:0015168
GO:0030165
GO:0015250
GO:0005372
GO:0030042
GO:0007568
GO:0006915
GO:0006884
GO:0071280
GO:0071288
GO:0042631
GO:0007565
GO:0006972
GO:0072205
GO:0051928
GO:0003097
GO:0051592
GO:0033762
GO:0009725
GO:0032496
GO:0010226
GO:0009651
GO:0042594
GO:0009414
GO:0030104
GO:0006833
Gene3D 1.20.1080.10
InterPro IPR023271
IPR000425
IPR022357
PANTHER PTHR19139
Pfam PF00230
PRINTS PR00783
SUPFAM SSF81338
TIGRFAMs TIGR00861
PROSITE PS00221

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016324

apical plasma membrane

PMID:17804457[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006833

water transport

PMID:9321919[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9321919[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005372

water transmembrane transporter activity

PMID:9321919[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070382

exocytic vesicle

PMID:15037626[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051928

positive regulation of calcium ion transport

PMID:18094031[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051592

response to calcium ion

PMID:19138132[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042631

cellular response to water deprivation

PMID:15196935[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042594

response to starvation

PMID:15610244[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033762

response to glucagon

PMID:18829741[8]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:15823548[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:15196935[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

GO:0003097

renal water transport

PMID:25658446[10]

ECO:0000314

P

Figure 2 immuno blotting

complete
CACAO 10640

involved_in

GO:0032496

response to lipopolysaccharide

PMID:18824919[11]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030165

PDZ domain binding

PMID:15196935[6]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1303184

F

Seeded From UniProt

complete

part_of

GO:0030136

clathrin-coated vesicle

PMID:18843259[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030133

transport vesicle

PMID:15196935[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030042

actin filament depolymerization

PMID:18678705[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:18971210[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:15579502[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:15037626[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:11518698[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:17339611[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

PMID:15579502[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010226

response to lithium ion

PMID:19244398[18]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

PMID:17376764[19]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009651

response to salt stress

PMID:12176047[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009414

response to water deprivation

PMID:18367658[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:18367658[21]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:18293204[22]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006972

hyperosmotic response

PMID:19138132[5]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:18717646[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006884

cell volume homeostasis

PMID:18094031[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006833

water transport

PMID:11518698[16]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:15905145[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005791

rough endoplasmic reticulum

PMID:15905145[24]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005769

early endosome

PMID:18843259[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

PMID:18843259[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19008911[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15579502[15]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:15336526[26]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106215
MGI:MGI:1096865
PANTHER:PTN000440694
RGD:2142
RGD:2144
UniProtKB:P41181
UniProtKB:P55064

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
FB:FBgn0015872
MGI:MGI:103201
PANTHER:PTN000440616
RGD:2143
UniProtKB:P06624

C

Seeded From UniProt

complete

enables

GO:0015250

water channel activity

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0015872
MGI:MGI:107387
MGI:MGI:1096865
MGI:MGI:96990
PANTHER:PTN000440616
RGD:2141
RGD:2143
RGD:3090
UniProtKB:P06624
UniProtKB:P29972
UniProtKB:P30301
UniProtKB:P41181
UniProtKB:P55064
UniProtKB:P55087
UniProtKB:Q5A1Z4
ZFIN:ZDB-GENE-030131-7764
ZFIN:ZDB-GENE-040801-41

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[27]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
MGI:MGI:103201
MGI:MGI:106215
MGI:MGI:107387
MGI:MGI:1096865
MGI:MGI:96990
PANTHER:PTN000440616
RGD:2141
RGD:2142
RGD:2143
RGD:2144
RGD:3090
UniProtKB:K7N7A8
UniProtKB:P06624
UniProtKB:P29972
UniProtKB:P30301
UniProtKB:P41181
UniProtKB:P55064
UniProtKB:P55087
UniProtKB:Q5A1Z4

C

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

P

Seeded From UniProt

complete

involved_in

GO:0030104

water homeostasis

PMID:15336526[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0015250

water channel activity

PMID:12176047[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006833

water transport

PMID:12176047[20]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0030659

cytoplasmic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0089

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0026

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Barone, S et al. (2007) Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Nephrol. Dial. Transplant. 22 3462-70 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Mulders, SM et al. (1997) Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Am. J. Physiol. 273 F451-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 Henn, V et al. (2004) Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J. Biol. Chem. 279 26654-65 PubMed GONUTS page
  4. ↑ 4.0 4.1 Galizia, L et al. (2008) Role of AQP2 in activation of calcium entry by hypotonicity: implications in cell volume regulation. Am. J. Physiol. Renal Physiol. 294 F582-90 PubMed GONUTS page
  5. ↑ 5.0 5.1 Gajghate, S et al. (2009) Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc. J. Bone Miner. Res. 24 992-1001 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Noda, Y et al. (2004) Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett. 568 139-45 PubMed GONUTS page
  7. ↑ Wilke, C et al. (2005) Vasopressin-independent regulation of collecting duct aquaporin-2 in food deprivation. Kidney Int. 67 201-16 PubMed GONUTS page
  8. ↑ Yano, Y et al. (2009) Aquaporin 2 expression increased by glucagon in normal rat inner medullary collecting ducts. Am. J. Physiol. Renal Physiol. 296 F54-9 PubMed GONUTS page
  9. ↑ Noda, Y et al. (2005) Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem. Biophys. Res. Commun. 330 1041-7 PubMed GONUTS page
  10. ↑ Lütken, SC et al. (2015) AVP-induced increase in AQP2 and p-AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidney. PLoS ONE 10 e0116501 PubMed GONUTS page
  11. ↑ Chagnon, F et al. (2008) Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Crit. Care Med. 36 3054-61 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Moeller, HB et al. (2009) Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Kidney Int. 75 295-303 PubMed GONUTS page
  13. ↑ Noda, Y et al. (2008) Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. J. Cell Biol. 182 587-601 PubMed GONUTS page
  14. ↑ Jensen, AM et al. (2009) Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction. Am. J. Physiol. Renal Physiol. 296 F127-34 PubMed GONUTS page
  15. ↑ 15.0 15.1 15.2 Kim, SW et al. (2004) Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney. J. Am. Soc. Nephrol. 15 2998-3005 PubMed GONUTS page
  16. ↑ 16.0 16.1 Gallardo, P et al. (2001) Aquaporin-2, a regulated water channel, is expressed in apical membranes of rat distal colon epithelium. Am. J. Physiol. Gastrointest. Liver Physiol. 281 G856-63 PubMed GONUTS page
  17. ↑ Watson, KJ et al. (2007) Expression of aquaporin water channels in rat taste buds. Chem. Senses 32 411-21 PubMed GONUTS page
  18. ↑ Zhang, Y et al. (2009) Potential role of purinergic signaling in lithium-induced nephrogenic diabetes insipidus. Am. J. Physiol. Renal Physiol. 296 F1194-201 PubMed GONUTS page
  19. ↑ de Seigneux, S et al. (2007) Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. Am. J. Physiol. Renal Physiol. 293 F87-99 PubMed GONUTS page
  20. ↑ 20.0 20.1 20.2 Roxas, B et al. (2002) Aquaporin-2 transcript is differentially regulated by dietary salt in Sprague-Dawley and Dahl SS/Jr rats. Biochem. Biophys. Res. Commun. 296 755-8 PubMed GONUTS page
  21. ↑ 21.0 21.1 Combet, S et al. (2008) Aquaporin-2 downregulation in kidney medulla of aging rats is posttranscriptional and is abolished by water deprivation. Am. J. Physiol. Renal Physiol. 294 F1408-14 PubMed GONUTS page
  22. ↑ Abreu, N et al. (2008) Hemodynamic parameters during normal and hypertensive pregnancy in rats: evaluation of renal salt and water transporters. Hypertens Pregnancy 27 49-63 PubMed GONUTS page
  23. ↑ Flamenco, P et al. (2009) Role of AQP2 during apoptosis in cortical collecting duct cells. Biol. Cell 101 237-50 PubMed GONUTS page
  24. ↑ 24.0 24.1 Barile, M et al. (2005) Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Mol. Cell Proteomics 4 1095-106 PubMed GONUTS page
  25. ↑ Okutsu, R et al. (2008) AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts. Kidney Int. 74 1429-33 PubMed GONUTS page
  26. ↑ 26.0 26.1 Noda, Y et al. (2004) Water channel aquaporin-2 directly binds to actin. Biochem. Biophys. Res. Commun. 322 740-5 PubMed GONUTS page
  27. ↑ 27.0 27.1 27.2 27.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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