PMID:18717646

Citation	Flamenco, P, Galizia, L, Rivarola, V, Fernandez, J, Ford, P and Capurro, C (2009) Role of AQP2 during apoptosis in cortical collecting duct cells. Biol. Cell 101:237-50
Abstract	A major hallmark of apoptosis is cell shrinkage, termed apoptotic volume decrease, due to the cellular outflow of potassium and chloride ions, followed by osmotically obliged water. In many cells, the ionic pathways triggered during the apoptotic volume decrease may be similar to that observed during a regulatory volume decrease response under hypotonic conditions. However, the pathways involved in water loss during apoptosis have been largely ignored. It was recently reported that in some systems this water movement is mediated via specific water channels (aquaporins). Nevertheless, it is important to identify whether this is a ubiquitous aspect of apoptosis as well as to define the mechanisms involved. The aim of the present work was to investigate the role of aquaporin-2 during apoptosis in renal-collecting duct cells. We evaluated the putative relationship between aquaporin-2 expression and the activation of the ionic pathways involved in the regulatory volume response.
Links	PubMed Online version:10.1042/BC20080050
Keywords	Animals; Apoptosis/physiology; Aquaporin 2/genetics; Aquaporin 2/metabolism; Barium Compounds/metabolism; Cell Line; Cell Membrane Permeability; Cell Size; Chlorides/metabolism; Cycloheximide/metabolism; DNA Fragmentation; Glyburide/metabolism; Humans; Ion Channels/metabolism; Kidney Tubules, Collecting/cytology; Kidney Tubules, Collecting/metabolism; Osmolar Concentration; Rats; Water/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:AQP2	involved_in	GO:0006915: apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

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