RAT:AAPK1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Prkaa1 (synonyms: Ampk1)
Protein Name(s)	5'-AMP-activated protein kinase catalytic subunit alpha-1 AMPK subunit alpha-1 Acetyl-CoA carboxylase kinase ACACA kinase Hydroxymethylglutaryl-CoA reductase kinase HMGCR kinase Tau-protein kinase PRKAA1
External Links
UniProt	P54645
EMBL	CH474048 U40819
RefSeq	NP_062015.2
UniGene	Rn.87789
PDB	2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4EAK 4EAL 4F2L 4QFG 4QFR 4QFS
PDBsum	2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4EAK 4EAL 4F2L 4QFG 4QFR 4QFS
ProteinModelPortal	P54645
BioGrid	249325
DIP	DIP-57168N
IntAct	P54645
MINT	MINT-4566241
STRING	10116.ENSRNOP00000017626
BindingDB	P54645
ChEMBL	CHEMBL4533
PhosphoSite	P54645
PRIDE	P54645
Ensembl	ENSRNOT00000017626
GeneID	65248
KEGG	rno:65248
CTD	5562
RGD	3387
eggNOG	COG0515
GeneTree	ENSGT00760000118892
HOGENOM	HOG000233016
HOVERGEN	HBG050432
InParanoid	P54645
KO	K07198
OMA	MKRATIR
OrthoDB	EOG7RRF6K
PhylomeDB	P54645
TreeFam	TF314032
BRENDA	2.7.11.1
Reactome	REACT_232838 REACT_236950
EvolutionaryTrace	P54645
NextBio	614203
PRO	PR:P54645
Proteomes	UP000002494
Genevestigator	P54645
GO	GO:0031588 GO:0016324 GO:0005737 GO:0005634 GO:0043234 GO:0050405 GO:0047322 GO:0004679 GO:0005524 GO:0003682 GO:0042557 GO:0035174 GO:0019900 GO:0046872 GO:0008022 GO:0004674 GO:0050321 GO:0000187 GO:0006914 GO:0071361 GO:0042149 GO:0070301 GO:0071456 GO:0031669 GO:0071417 GO:0006695 GO:0009631 GO:0006633 GO:0055089 GO:0019395 GO:0042593 GO:0006006 GO:0008610 GO:0043066 GO:2001274 GO:0050995 GO:0032007 GO:0017148 GO:0010508 GO:0008284 GO:0046321 GO:0010628 GO:0045722 GO:0046326 GO:0045821 GO:0051291 GO:0006468 GO:0042752 GO:2000505 GO:0006355 GO:0060627 GO:0014823 GO:0031000 GO:1901563 GO:0010332 GO:0009411 GO:0048511 GO:0006351 GO:0016055
InterPro	IPR028375 IPR011009 IPR028797 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24343:SF81
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF103243 SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0030424	axon	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(GO:0030424) occurs_in:(CL:0002608)\|occurs_in:(GO:0030425) occurs_in:(CL:0002608)\|occurs_in:(GO:0043025) occurs_in:(CL:0002608)	Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:25788287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:39124) part_of:(GO:0071277)\|occurs_in(GO:0030424) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0030425) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)\|occurs_in(GO:0043025) occurs_in:(CL:0002608) activated_by:(CHEBI:15866) part_of:(GO:0071333)	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	PMID:11724780^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055089	fatty acid homeostasis	PMID:11724780^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:11903059^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046321	positive regulation of fatty acid oxidation	PMID:11997383^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	PMID:11069105^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045722	positive regulation of gluconeogenesis	PMID:11903059^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
enables	GO:0042557	eukaryotic elongation factor-2 kinase activator activity	PMID:12194824^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	F		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:17851531^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21399626^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:12194824^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:18256313^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9845345^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18256313^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:21399626^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:11724780^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:11069105^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q5EG47	F		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:17720864^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071417	cellular response to organonitrogen compound	PMID:19236843^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071361	cellular response to ethanol	PMID:20164678^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:18081811^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060627	regulation of vesicle-mediated transport	PMID:19139597^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:14511394^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:20501641^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:14511394^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:16648175^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	PMID:19608206^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:17253964^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009631	cold acclimation	PMID:21945600^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17720864^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:15695819^[22]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:71057	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8955377^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16648175^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16648175^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:8955377^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:10698692^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:16648175^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	PMID:14511394^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8955377^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336173 MGI:MGI:2145955 PANTHER:PTN001217363	P		Seeded From UniProt	complete
part_of	GO:0031588	nucleotide-activated protein kinase complex	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001217363 RGD:3387 RGD:620893	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042557	P		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0035404	histone-serine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0035174	P		Seeded From UniProt	complete
involved_in	GO:0070050	neuron cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0061762	CAMKK-AMPK signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0061744	motor behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13131 ensembl:ENSP00000346148	F		Seeded From UniProt	complete
involved_in	GO:2000758	positive regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:1904428	negative regulation of tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:1903829	positive regulation of cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:1903109	positive regulation of mitochondrial transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:1901563	response to camptothecin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0071380	cellular response to prostaglandin E stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0062028	regulation of stress granule assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0050995	negative regulation of lipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	C		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
enables	GO:0035174	histone serine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0033135	regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0031669	cellular response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	C		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0008610	lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	C		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5EG47 ensembl:ENSMUSP00000063166	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004679	AMP-activated protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039137	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
enables	GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.31	F		Seeded From UniProt	complete
enables	GO:0050405	[acetyl-CoA carboxylase] kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.27	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-9619534 Reactome:R-NUL-9619488	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016126	sterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0756	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0153	P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0152	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0006694	steroid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0752	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0008202	steroid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0753	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kawaguchi, T et al. (2002) Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J. Biol. Chem. 277 3829-35 PubMed GONUTS page
↑ ^3.0 ^3.1 Fryer, LG et al. (2002) Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem. J. 363 167-74 PubMed GONUTS page
↑ Bolster, DR et al. (2002) AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J. Biol. Chem. 277 23977-80 PubMed GONUTS page
↑ ^5.0 ^5.1 Marsin, AS et al. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr. Biol. 10 1247-55 PubMed GONUTS page
↑ ^6.0 ^6.1 Horman, S et al. (2002) Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 12 1419-23 PubMed GONUTS page
↑ Xiao, B et al. (2007) Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449 496-500 PubMed GONUTS page
↑ ^8.0 ^8.1 Xiao, B et al. (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472 230-3 PubMed GONUTS page
↑ ^9.0 ^9.1 Cammisotto, PG et al. (2008) Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Am. J. Physiol. Renal Physiol. 294 F881-9 PubMed GONUTS page
↑ Velasco, G et al. (1998) Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. FEBS Lett. 439 317-20 PubMed GONUTS page
↑ ^11.0 ^11.1 Fukuyama, Y et al. (2007) Hypoxia induces expression and activation of AMPK in rat dental pulp cells. J. Dent. Res. 86 903-7 PubMed GONUTS page
↑ Liangpunsakul, S et al. (2009) Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Arch. Biochem. Biophys. 485 10-5 PubMed GONUTS page
↑ Chen, L et al. (2010) Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. Exp. Mol. Med. 42 205-15 PubMed GONUTS page
↑ Fukuyama, Y et al. (2008) Hydrogen peroxide induces expression and activation of AMP-activated protein kinase in a dental pulp cell line. Int Endod J 41 197-203 PubMed GONUTS page
↑ Yuasa, T et al. (2009) The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Galphaq-mediated intracellular GLUT4 vesicle distribution. Endocr. J. 56 345-59 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Hawley, SA et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2 28 PubMed GONUTS page
↑ Gaidhu, MP et al. (2010) Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes. Mol. Endocrinol. 24 1434-40 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Li, J et al. (2006) Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Am. J. Physiol. Heart Circ. Physiol. 291 H1927-34 PubMed GONUTS page
↑ Egawa, T et al. (2009) Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metab. Clin. Exp. 58 1609-17 PubMed GONUTS page
↑ Koh, HJ et al. (2007) Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Biochem. J. 403 473-81 PubMed GONUTS page
↑ Vucetic, M et al. (2011) Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1α and AMPKα. Biochim. Biophys. Acta 1810 1252-61 PubMed GONUTS page
↑ Iseli, TJ et al. (2005) AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J. Biol. Chem. 280 13395-400 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Woods, A et al. (1996) The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Lett. 397 347-51 PubMed GONUTS page
↑ Cheung, PC et al. (2000) Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem. J. 346 Pt 3 659-69 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 ^25.6 ^25.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25788287-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Sample, V et al. (2015) Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol. Biol. Cell 26 1935-46 PubMed GONUTS page

[PMID:11724780-2] 2.0 ^2.1 ^2.2 Kawaguchi, T et al. (2002) Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J. Biol. Chem. 277 3829-35 PubMed GONUTS page

[PMID:11903059-3] 3.0 ^3.1 Fryer, LG et al. (2002) Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem. J. 363 167-74 PubMed GONUTS page

[PMID:11997383-4] Bolster, DR et al. (2002) AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J. Biol. Chem. 277 23977-80 PubMed GONUTS page

[PMID:11069105-5] 5.0 ^5.1 Marsin, AS et al. (2000) Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia. Curr. Biol. 10 1247-55 PubMed GONUTS page

[PMID:12194824-6] 6.0 ^6.1 Horman, S et al. (2002) Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr. Biol. 12 1419-23 PubMed GONUTS page

[PMID:17851531-7] Xiao, B et al. (2007) Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449 496-500 PubMed GONUTS page

[PMID:21399626-8] 8.0 ^8.1 Xiao, B et al. (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472 230-3 PubMed GONUTS page

[PMID:18256313-9] 9.0 ^9.1 Cammisotto, PG et al. (2008) Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Am. J. Physiol. Renal Physiol. 294 F881-9 PubMed GONUTS page

[PMID:9845345-10] Velasco, G et al. (1998) Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. FEBS Lett. 439 317-20 PubMed GONUTS page

[PMID:17720864-11] 11.0 ^11.1 Fukuyama, Y et al. (2007) Hypoxia induces expression and activation of AMPK in rat dental pulp cells. J. Dent. Res. 86 903-7 PubMed GONUTS page

[PMID:19236843-12] Liangpunsakul, S et al. (2009) Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Arch. Biochem. Biophys. 485 10-5 PubMed GONUTS page

[PMID:20164678-13] Chen, L et al. (2010) Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. Exp. Mol. Med. 42 205-15 PubMed GONUTS page

[PMID:18081811-14] Fukuyama, Y et al. (2008) Hydrogen peroxide induces expression and activation of AMP-activated protein kinase in a dental pulp cell line. Int Endod J 41 197-203 PubMed GONUTS page

[PMID:19139597-15] Yuasa, T et al. (2009) The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Galphaq-mediated intracellular GLUT4 vesicle distribution. Endocr. J. 56 345-59 PubMed GONUTS page

[PMID:14511394-16] 16.0 ^16.1 ^16.2 Hawley, SA et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2 28 PubMed GONUTS page

[PMID:20501641-17] Gaidhu, MP et al. (2010) Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes. Mol. Endocrinol. 24 1434-40 PubMed GONUTS page

[PMID:16648175-18] 18.0 ^18.1 ^18.2 ^18.3 Li, J et al. (2006) Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart. Am. J. Physiol. Heart Circ. Physiol. 291 H1927-34 PubMed GONUTS page

[PMID:19608206-19] Egawa, T et al. (2009) Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metab. Clin. Exp. 58 1609-17 PubMed GONUTS page

[PMID:17253964-20] Koh, HJ et al. (2007) Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Biochem. J. 403 473-81 PubMed GONUTS page

[PMID:21945600-21] Vucetic, M et al. (2011) Interscapular brown adipose tissue metabolic reprogramming during cold acclimation: Interplay of HIF-1α and AMPKα. Biochim. Biophys. Acta 1810 1252-61 PubMed GONUTS page

[PMID:15695819-22] Iseli, TJ et al. (2005) AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J. Biol. Chem. 280 13395-400 PubMed GONUTS page

[PMID:8955377-23] 23.0 ^23.1 ^23.2 Woods, A et al. (1996) The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro. FEBS Lett. 397 347-51 PubMed GONUTS page

[PMID:10698692-24] Cheung, PC et al. (2000) Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem. J. 346 Pt 3 659-69 PubMed GONUTS page

[PMID:21873635-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 ^25.6 ^25.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

RAT:AAPK1

Contents

Annotations

Notes

References

(

a

c

d

e

f

g

i

k

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools