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PMID:19236843
| Citation |
Liangpunsakul, S, Wou, SE, Wineinger, KD, Zeng, Y, Cyganek, I, Jayaram, HN and Crabb, DW (2009) Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase. Arch. Biochem. Biophys. 485:10-5 |
|---|---|
| Abstract |
AMP-dependent protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR) alpha facilitate fatty acid oxidation. We have shown that treatment of hepatoma cells with ethanol or feeding ethanol-containing diets to mice inhibited both PPARalpha and AMPK activity. Importantly, WY-14,643 reversed the development of fatty liver in alcohol-fed mice. Whether WY-14,643, a PPARalpha agonist, has any effects on AMPK is not known. The aim of this study was to investigate the effect of WY-14,643 on AMPK activity. |
| Links |
PubMed PMC2692688 Online version:10.1016/j.abb.2009.02.006 |
| Keywords |
AMP-Activated Protein Kinases/genetics; AMP-Activated Protein Kinases/metabolism; Adenosine Monophosphate/metabolism; Adenosine Triphosphate/metabolism; Cell Line; Energy Metabolism/drug effects; Enzyme Activation/drug effects; Gene Expression Regulation, Enzymologic/drug effects; PPAR alpha/metabolism; Phosphorylation/drug effects; Protein Kinase C/metabolism; Pyrimidines/pharmacology; Reactive Oxygen Species/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071417: cellular response to organonitrogen compound |
ECO:0000270: expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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