MOUSE:ZEB1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Zeb1 (synonyms: Tcf8, Zfhx1a, Zfx1a, Zfx1ha)
Protein Name(s)	Zinc finger E-box-binding homeobox 1 Delta EF1 Transcription factor 8 TCF-8 Zinc finger homeobox protein 1a MEB1
External Links
UniProt	Q64318
EMBL	U26259 D76432 L48363 BC139769
CCDS	CCDS29039.1
PIR	JC4934
RefSeq	NP_035676.1
UniGene	Mm.3929
ProteinModelPortal	Q64318
SMR	Q64318
BioGrid	204010
DIP	DIP-60280N
IntAct	Q64318
PhosphoSite	Q64318
MaxQB	Q64318
PRIDE	Q64318
Ensembl	ENSMUST00000025081
GeneID	21417
KEGG	mmu:21417
UCSC	uc008dyy.2
CTD	6935
MGI	MGI:1344313
eggNOG	COG5048
GeneTree	ENSGT00630000089829
HOGENOM	HOG000264256
HOVERGEN	HBG004697
InParanoid	Q64318
KO	K09299
OMA	ECEKPQG
OrthoDB	EOG790G0D
PhylomeDB	Q64318
TreeFam	TF331759
ChiTaRS	Zeb1
NextBio	300720
PRO	PR:Q64318
Proteomes	UP000000589
Bgee	Q64318
CleanEx	MM_ZEB1
ExpressionAtlas	Q64318
Genevestigator	Q64318
GO	GO:0005737 GO:0005634 GO:0005667 GO:0003682 GO:0003690 GO:0070888 GO:0046872 GO:0003700 GO:0008134 GO:0051216 GO:0071230 GO:0071560 GO:0007417 GO:0090103 GO:0048596 GO:0048598 GO:0048704 GO:0030900 GO:0008285 GO:0030857 GO:0000122 GO:0045892 GO:0048513 GO:0007389 GO:0045666 GO:0045944 GO:0010464 GO:0051150 GO:0033081 GO:0017015 GO:0014823 GO:0031667 GO:0048752 GO:0006351
Gene3D	1.10.10.60 3.30.160.60
InterPro	IPR008598 IPR001356 IPR009057 IPR007087 IPR015880 IPR013087
Pfam	PF05605
SMART	SM00389 SM00355
SUPFAM	SSF46689
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0070888	E-box binding	PMID:20346398^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20346398^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37275	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:20346398^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20346398^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
	GO:0033235	positive regulation of protein sumoylation	PMID:17392792^[2]	ECO:0000315			P		Fig 5g	complete CACAO 8905
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:21980308^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861230	P	has_participant:(EMAPA:17598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051216	cartilage development	PMID:9389660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857799	P	results_in_development_of:(EMAPA:17907)\|results_in_development_of:(EMAPA:17608)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051150	regulation of smooth muscle cell differentiation	PMID:16824956^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048752	semicircular canal morphogenesis	PMID:21980308^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861230	P	has_participant:(EMAPA:17821)\|has_participant:(EMAPA:17296)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:9389660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857799	P	has_participant:(EMAPA:17412)\|has_participant:(EMAPA:17458)\|has_participant:(EMAPA:17214)\|has_participant:(EMAPA:18344)\|has_participant:(EMAPA:18706)\|has_participant:(EMAPA:18290)\|has_participant:(EMAPA:17928)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048598	embryonic morphogenesis	PMID:16598713^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1344407	P	has_participant:(EMAPA:16681)\|has_participant:(EMAPA:17359)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048596	embryonic camera-type eye morphogenesis	PMID:18436818^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048513	animal organ development	PMID:11681996^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861230	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16824956^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106658 MGI:MGI:894293	P	has_regulation_target:(MGI:MGI:87909)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16824956^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:106658 MGI:MGI:1201674	P	has_regulation_target:(MGI:MGI:87909)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16824956^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:87909)\|has_regulation_target:(MGI:MGI:106012)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045602	negative regulation of endothelial cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033081	regulation of T cell differentiation in thymus	PMID:9389660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857799	P	occurs_in:(EMAPA:18768) regulates_o_results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033081	regulation of T cell differentiation in thymus	PMID:9126927^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857515	P	occurs_in:(EMAPA:18768) regulates_o_results_in_acquisition_of_features_of:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030857	negative regulation of epithelial cell differentiation	PMID:18192284^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16198)\|occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	PMID:16824956^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010464	regulation of mesenchymal cell proliferation	PMID:18192284^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:18436818^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857515	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17392792^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88712 UniProtKB:Q6ZQ88	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:16598713^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1344407	P	results_in_development_of:(EMAPA:16910)\|results_in_development_of:(EMAPA:17700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:9389660^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857799	P	occurs_in:(EMAPA:17412)\|occurs_in:(EMAPA:17458)\|occurs_in:(EMAPA:17214)\|occurs_in:(EMAPA:18344)\|occurs_in:(EMAPA:18706)\|occurs_in:(EMAPA:18290)\|occurs_in:(EMAPA:17928)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17392792^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14643678^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17392792^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:35998) occurs_in:(CL:0000439) has_regulation_target:(MGI:MGI:95707)	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16824956^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:87909)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:24735878^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	regulates_o_occurs_in:(CL:0000312) occurs_in:(CL:0000312) has_direct_input:(MGI:MGI:88274)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17392792^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95707)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3831	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	P		Seeded From UniProt	complete
involved_in	GO:0045602	negative regulation of endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	C		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37275 ensembl:ENSP00000354487	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ravanpay, AC et al. (2010) Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. Mol. Cell. Neurosci. 44 178-89 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page
↑ ^3.0 ^3.1 Kurima, K et al. (2011) A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet. 7 e1002307 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Takagi, T et al. (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development 125 21-31 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Nishimura, G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev. Cell 11 93-104 PubMed GONUTS page
↑ ^7.0 ^7.1 Miyoshi, T et al. (2006) Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev. Dyn. 235 1941-52 PubMed GONUTS page
↑ ^8.0 ^8.1 Liu, Y et al. (2008) Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 49 1843-9 PubMed GONUTS page
↑ Gong, SG & Eulenberg, RL (2001) Palatal development in Twirler mice. Cleft Palate Craniofac. J. 38 622-8 PubMed GONUTS page
↑ Higashi, Y et al. (1997) Impairment of T cell development in deltaEF1 mutant mice. J. Exp. Med. 185 1467-79 PubMed GONUTS page
↑ ^11.0 ^11.1 Liu, Y et al. (2008) Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 135 579-88 PubMed GONUTS page
↑ Darling, DS et al. (2003) Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr. Patterns 3 709-17 PubMed GONUTS page
↑ Lee, B et al. (2014) Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev. Cell 29 47-58 PubMed GONUTS page

[PMID:20346398-1] 1.0 ^1.1 ^1.2 ^1.3 Ravanpay, AC et al. (2010) Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. Mol. Cell. Neurosci. 44 178-89 PubMed GONUTS page

[PMID:17392792-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page

[PMID:21980308-3] 3.0 ^3.1 Kurima, K et al. (2011) A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet. 7 e1002307 PubMed GONUTS page

[PMID:20548288-4] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:9389660-5] 5.0 ^5.1 ^5.2 ^5.3 Takagi, T et al. (1998) DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development 125 21-31 PubMed GONUTS page

[PMID:16824956-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Nishimura, G et al. (2006) DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev. Cell 11 93-104 PubMed GONUTS page

[PMID:16598713-7] 7.0 ^7.1 Miyoshi, T et al. (2006) Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev. Dyn. 235 1941-52 PubMed GONUTS page

[PMID:18436818-8] 8.0 ^8.1 Liu, Y et al. (2008) Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 49 1843-9 PubMed GONUTS page

[PMID:11681996-9] Gong, SG & Eulenberg, RL (2001) Palatal development in Twirler mice. Cleft Palate Craniofac. J. 38 622-8 PubMed GONUTS page

[PMID:9126927-10] Higashi, Y et al. (1997) Impairment of T cell development in deltaEF1 mutant mice. J. Exp. Med. 185 1467-79 PubMed GONUTS page

[PMID:18192284-11] 11.0 ^11.1 Liu, Y et al. (2008) Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 135 579-88 PubMed GONUTS page

[PMID:14643678-12] Darling, DS et al. (2003) Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr. Patterns 3 709-17 PubMed GONUTS page

[PMID:24735878-13] Lee, B et al. (2014) Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev. Cell 29 47-58 PubMed GONUTS page

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MOUSE:ZEB1

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