PMID:18436818

Citation	Liu, Y, Peng, X, Tan, J, Darling, DS, Kaplan, HJ and Dean, DC (2008) Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest. Ophthalmol. Vis. Sci. 49:1843-9
Abstract	The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo. Overexpression of Zeb1 in cancer triggers epithelial-mesenchymal transition, which facilitates metastasis. The mutation of ZEB1 in humans is linked to posterior polymorphous corneal dystrophy (PPCD), in which an epithelial transition of the corneal endothelium is associated with abnormal endothelial proliferation. The purpose of this study is to determine whether Zeb1 null or heterozygous mice may provide an animal model for PPCD.
Links	PubMed PMC2504018 Online version:10.1167/iovs.07-0789
Keywords	Animals; Autoantigens/genetics; Autoantigens/metabolism; Bromodeoxyuridine/metabolism; Cadherins/genetics; Cadherins/metabolism; Cell Proliferation; Collagen Type IV/genetics; Collagen Type IV/metabolism; Corneal Dystrophies, Hereditary/embryology; Corneal Dystrophies, Hereditary/genetics; Corneal Dystrophies, Hereditary/pathology; Disease Models, Animal; Endothelium, Corneal/embryology; Endothelium, Corneal/metabolism; Endothelium, Corneal/pathology; Epithelium, Corneal/embryology; Epithelium, Corneal/metabolism; Epithelium, Corneal/pathology; Female; Fibroblasts/metabolism; Fluorescent Antibody Technique, Indirect; Gene Dosage; Genotype; Homeodomain Proteins/physiology; Kruppel-Like Transcription Factors/physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation/physiology; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Zinc Fingers/physiology
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