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PMID:11681996
| Citation |
Gong, SG and Eulenberg, RL (2001) Palatal development in Twirler mice. Cleft Palate Craniofac. J. 38:622-8 |
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| Abstract |
OBJECTIVE: The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted. RESULTS AND CONCLUSIONS: The secondary palatal shelves were retarded in growth and the timing of elevation from a vertical to horizontal position. The homozygous Tw embryos, when compared with their wild-type littermates, also had a significantly wider midface. It is not surprising, therefore, that the short palatal shelves in a wide midface resulted in cleftings of the secondary palate observed in all homozygous Tw mice. These findings are consistent with similar studies in humans and other murine models. |
| Links |
PubMed Online version:<0622:PDITM>2.0.CO;2 10.1597/1545-1569(2001)038<0622:PDITM>2.0.CO;2 |
| Keywords |
Animals; Cephalometry; Cleft Palate/embryology; Coloring Agents/diagnostic use; Disease Models, Animal; Embryo, Mammalian; Embryonic and Fetal Development; Eosine Yellowish-(YS)/diagnostic use; Fluorescent Dyes/diagnostic use; Gestational Age; Hematoxylin/diagnostic use; Homozygote; Image Processing, Computer-Assisted; Mice; Mice, Mutant Strains; Palate/embryology; Skull/embryology; Statistics as Topic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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