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MOUSE:SYCP1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sycp1 (synonyms: Scp1)
Protein Name(s) Synaptonemal complex protein 1

SCP-1

External Links
UniProt Q62209
EMBL Z38118
L41069
AH006782
AC122219
AC134871
BC137967
D88539
CCDS CCDS38567.1
PIR S49461
RefSeq NP_035646.2
XP_006501290.1
UniGene Mm.243849
ProteinModelPortal Q62209
SMR Q62209
BioGrid 203596
IntAct Q62209
MINT MINT-8144437
PhosphoSite Q62209
PRIDE Q62209
Ensembl ENSMUST00000029448
GeneID 20957
KEGG mmu:20957
UCSC uc008qrz.2
CTD 6847
MGI MGI:105931
eggNOG NOG147666
GeneTree ENSGT00390000003368
HOGENOM HOG000154467
HOVERGEN HBG059062
InParanoid Q62209
OMA QLNVYEI
OrthoDB EOG7KH9JR
TreeFam TF331737
Reactome REACT_198626
REACT_75800
NextBio 299908
PRO PR:Q62209
Proteomes UP000000589
Bgee Q62209
CleanEx MM_SYCP1
Genevestigator Q62209
GO GO:0000801
GO:0005694
GO:0000800
GO:0001673
GO:0005654
GO:0000795
GO:0000802
GO:0003677
GO:0051026
GO:0051878
GO:0000711
GO:0032880
GO:0035092
GO:0007283
GO:0007130
InterPro IPR008827
PANTHER PTHR18878
Pfam PF05483

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15431

P

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q15431

F

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:15937223[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:15937223[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007129

synapsis

PMID:15937223[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007130

synaptonemal complex assembly

PMID:15937223[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007130

synaptonemal complex assembly

PMID:15944401[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051878

lateral element assembly

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051289

protein homotetramerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15431

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051026

chiasma assembly

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

occurs_in:(CL:0000023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035092

sperm chromatin condensation

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032880

regulation of protein localization

PMID:16968740[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3580000

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007130

synaptonemal complex assembly

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007130

synaptonemal complex assembly

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:105931

P

occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007130

synaptonemal complex assembly

PMID:22164254[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3580000

P

occurs_in:(CL:0000023)

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

PMID:10794082[5]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000023)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3794

C

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q15431

F

Seeded From UniProt

complete

part_of

GO:0001673

male germ cell nucleus

PMID:17696610[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000802

transverse filament

PMID:22711701[7]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000802

transverse filament

PMID:21539824[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000802

transverse filament

PMID:18283110[9]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000802

transverse filament

PMID:15870106[10]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17965)
  • part_of:(CL:0000654)

Seeded From UniProt

complete

part_of

GO:0000802

transverse filament

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3794

C

Seeded From UniProt

complete

part_of

GO:0000801

central element

PMID:23133398[11]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000801

central element

PMID:12584241[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:27856912[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:27760146[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:27473657[15]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:31484)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:26490168[16]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:26358182[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:25675407[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:22011390[19]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:20551173[20]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:18316482[21]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:18070917[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000023)|part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:17696610[6]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:16968740[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:16968740[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:12815066[23]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3794

C

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

PMID:16968740[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62209

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:24891606[24]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:24589552[25]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:22863743[26]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:22854038[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000711

meiotic DNA repair synthesis

PMID:22164254[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:109542

P

occurs_in:(CL:0000023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000711

meiotic DNA repair synthesis

PMID:22164254[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3580000

P

occurs_in:(CL:0000023)

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15431
ensembl:ENSP00000358535

P

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q15431
ensembl:ENSP00000358535

F

Seeded From UniProt

complete

part_of

GO:0000795

synaptonemal complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008827

C

Seeded From UniProt

complete

involved_in

GO:0007130

synaptonemal complex assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008827

P

Seeded From UniProt

complete

part_of

GO:0000800

lateral element

PMID:15944401[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-912506

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137
UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158
UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 de Vries, FA et al. (2005) Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. Genes Dev. 19 1376-89 PubMed GONUTS page
  2. ↑ 2.0 2.1 Costa, Y et al. (2005) Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis. J. Cell. Sci. 118 2755-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Kouznetsova, A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS ONE 6 e28255 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Hamer, G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J. Cell. Sci. 119 4025-32 PubMed GONUTS page
  5. ↑ Di Carlo, AD et al. (2000) The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int. J. Dev. Biol. 44 241-4 PubMed GONUTS page
  6. ↑ 6.0 6.1 Li, XC et al. (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet. 3 e130 PubMed GONUTS page
  7. ↑ Llano, E et al. (2012) Meiotic cohesin complexes are essential for the formation of the axial element in mice. J. Cell Biol. 197 877-85 PubMed GONUTS page
  8. ↑ Beyret, E & Lin, H (2011) Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev. Biol. 355 215-26 PubMed GONUTS page
  9. ↑ Yang, F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J. Cell Biol. 180 673-9 PubMed GONUTS page
  10. ↑ Kouznetsova, A et al. (2005) SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J. Cell. Sci. 118 2271-8 PubMed GONUTS page
  11. ↑ Berkowitz, KM et al. (2012) Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 8 e1002996 PubMed GONUTS page
  12. ↑ Parra, MT et al. (2003) Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis. J. Cell. Sci. 116 961-74 PubMed GONUTS page
  13. ↑ Barau, J et al. (2016) The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science 354 909-912 PubMed GONUTS page
  14. ↑ Finsterbusch, F et al. (2016) Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. PLoS Genet. 12 e1006393 PubMed GONUTS page
  15. ↑ Inoue, H et al. (2016) Mouse D1Pas1, a DEAD-box RNA helicase, is required for the completion of first meiotic prophase in male germ cells. Biochem. Biophys. Res. Commun. 478 592-8 PubMed GONUTS page
  16. ↑ Sun, X et al. (2016) FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma 125 237-52 PubMed GONUTS page
  17. ↑ Luangpraseuth-Prosper, A et al. (2015) TOPAZ1, a germ cell specific factor, is essential for male meiotic progression. Dev. Biol. 406 158-71 PubMed GONUTS page
  18. ↑ Tang, MC et al. (2015) Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice. PLoS Genet. 11 e1004964 PubMed GONUTS page
  19. ↑ La Salle, S et al. (2012) Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biol. Reprod. 86 45 PubMed GONUTS page
  20. ↑ Kumar, R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 24 1266-80 PubMed GONUTS page
  21. ↑ Yang, F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 22 682-91 PubMed GONUTS page
  22. ↑ Ryu, KY et al. (2008) The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol. Cell. Biol. 28 1136-46 PubMed GONUTS page
  23. ↑ Tay, J et al. (2003) Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev. 17 1457-62 PubMed GONUTS page
  24. ↑ Holloway, JK et al. (2014) Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J. Cell Biol. 205 633-41 PubMed GONUTS page
  25. ↑ Ishiguro, K et al. (2014) Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 28 594-607 PubMed GONUTS page
  26. ↑ Modzelewski, AJ et al. (2012) AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline. Dev. Cell 23 251-64 PubMed GONUTS page
  27. ↑ Jordan, PW et al. (2012) Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes. J. Cell. Sci. 125 5061-72 PubMed GONUTS page
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