MOUSE:SQSTM

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sqstm1 (synonyms: A170, STAP)
Protein Name(s)	Sequestosome-1 STONE14 Ubiquitin-binding protein p62
External Links
UniProt	Q64337
EMBL	U40930 U57413 AK028898 AL627187 AL627187 BC006019
CCDS	CCDS24629.1 CCDS70176.1
PIR	JC4978
RefSeq	NP_001277698.1 NP_035148.1
UniGene	Mm.40828
PDB	2RRU 2ZJD 3ADE 3B0F 3WDZ
PDBsum	2RRU 2ZJD 3ADE 3B0F 3WDZ
ProteinModelPortal	Q64337
SMR	Q64337
BioGrid	201982
DIP	DIP-38490N
IntAct	Q64337
MINT	MINT-1728610
STRING	10090.ENSMUSP00000099835
PhosphoSite	Q64337
MaxQB	Q64337
PaxDb	Q64337
PRIDE	Q64337
Ensembl	ENSMUST00000015981 ENSMUST00000102774
GeneID	18412
KEGG	mmu:18412
UCSC	uc007irw.1 uc007irx.1
CTD	8878
MGI	MGI:107931
eggNOG	NOG278569
GeneTree	ENSGT00390000002781
HOGENOM	HOG000154407
HOVERGEN	HBG052750
InParanoid	Q64337
KO	K14381
OMA	SVCPNYD
OrthoDB	EOG74R1RT
PhylomeDB	Q64337
TreeFam	TF328470
Reactome	REACT_202271 REACT_214670 REACT_218887 REACT_224208
ChiTaRS	Sqstm1
EvolutionaryTrace	Q64337
NextBio	294036
PRO	PR:Q64337
Proteomes	UP000000589
Bgee	Q64337
CleanEx	MM_SQSTM1
ExpressionAtlas	Q64337
Genevestigator	Q64337
GO	GO:0016235 GO:0005776 GO:0000932 GO:0031410 GO:0005783 GO:0070062 GO:0005770 GO:0005764 GO:0016605 GO:0000407 GO:0042802 GO:0070530 GO:0005080 GO:0042169 GO:0003712 GO:0043130 GO:0008270 GO:0006915 GO:0006914 GO:0030154 GO:0002376 GO:0016236 GO:0016239 GO:0001934 GO:0051291 GO:0043122 GO:1903506
InterPro	IPR000270 IPR009060 IPR015940 IPR000433
Pfam	PF00564 PF00569
SMART	SM00666 SM00165 SM00291
SUPFAM	SSF46934
PROSITE	PS50030 PS01357 PS50135

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0044130	negative regulation of growth of symbiont in host	PMID:23148214^[1]	ECO:0000315			P		FIGURE 4, 5	complete CACAO 5860
involved_in	GO:0061912	selective autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:1905719	protein localization to perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:0007032	endosome organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:0035973	aggrephagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	PMID:23148214^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:19004011^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P23818)	Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:19004011^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	PMID:19004011^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23818 UniProtKB:P23819 UniProtKB:Q9Z2W9	F		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:16252010^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q14596	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107931 PANTHER:PTN000387090 UniProtKB:Q13501	F		Seeded From UniProt	complete
part_of	GO:0044753	amphisome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	C		Seeded From UniProt	complete
involved_in	GO:0035973	aggrephagy	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107931 PANTHER:PTN000387090	C		Seeded From UniProt	complete
involved_in	GO:0007032	endosome organization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003231 PANTHER:PTN000387090	P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003231 MGI:MGI:107931 PANTHER:PTN000387090 UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 RGD:69287 UniProtKB:Q13501	F		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000387090 UniProtKB:Q13501	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905719	protein localization to perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0097413	Lewy body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	C		Seeded From UniProt	complete
part_of	GO:0097225	sperm midpiece	PMID:22033522^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0009566)	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061912	selective autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061635	regulation of protein complex stability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051291	protein heterooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	P		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	PMID:26284655^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
part_of	GO:0044753	amphisome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21220506^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035973	aggrephagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016236	macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:22792322^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007032	endosome organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:24713655^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002372) part_of:(CL:0002372)	Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:24954904^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69287	P		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000423	mitophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13501	P		Seeded From UniProt	complete
part_of	GO:0000407	phagophore assembly site	PMID:21220506^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:24035364^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3774352	P	has_regulation_target:(MGI:MGI:1309998) has_regulation_target:(MGI:MGI:103187) occurs_in:(CL:0000235) regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0097413	Lewy body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	C		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08623 ensembl:ENSRNOP00000056021	P		Seeded From UniProt	complete
involved_in	GO:1905719	protein localization to perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
involved_in	GO:0098780	response to mitochondrial depolarisation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
involved_in	GO:0061912	selective autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
involved_in	GO:0061635	regulation of protein complex stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
part_of	GO:0044753	amphisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
involved_in	GO:0035973	aggrephagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
involved_in	GO:0007032	endosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	C		Seeded From UniProt	complete
involved_in	GO:0000423	mitophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13501 ensembl:ENSP00000374455	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000433	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:10458914^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458 UniProtKB-SubCell:SL-0158	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0313	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0023	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Abdulrahman, BA et al. (2013) Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery. J. Biol. Chem. 288 2049-58 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Jiang, J et al. (2009) AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus 19 392-406 PubMed GONUTS page
↑ Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Al Rawi, S et al. (2011) Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 334 1144-7 PubMed GONUTS page
↑ Varga, RE et al. (2015) In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. PLoS Genet. 11 e1005454 PubMed GONUTS page
↑ ^7.0 ^7.1 Itakura, E & Mizushima, N (2011) p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J. Cell Biol. 192 17-27 PubMed GONUTS page
↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
↑ Sala, D et al. (2014) Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. J. Clin. Invest. 124 1914-27 PubMed GONUTS page
↑ Dooley, HC et al. (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol. Cell 55 238-52 PubMed GONUTS page
↑ Bonilla, DL et al. (2013) Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity 39 537-47 PubMed GONUTS page
↑ Okazaki, M et al. (1999) Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. Genomics 60 87-95 PubMed GONUTS page

[PMID:23148214-1] 1.0 ^1.1 Abdulrahman, BA et al. (2013) Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery. J. Biol. Chem. 288 2049-58 PubMed GONUTS page

[PMID:19004011-2] 2.0 ^2.1 ^2.2 Jiang, J et al. (2009) AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62. Hippocampus 19 392-406 PubMed GONUTS page

[PMID:16252010-3] Geetha, T et al. (2005) TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 24 3859-68 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22033522-5] Al Rawi, S et al. (2011) Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 334 1144-7 PubMed GONUTS page

[PMID:26284655-6] Varga, RE et al. (2015) In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. PLoS Genet. 11 e1005454 PubMed GONUTS page

[PMID:21220506-7] 7.0 ^7.1 Itakura, E & Mizushima, N (2011) p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J. Cell Biol. 192 17-27 PubMed GONUTS page

[PMID:22792322-8] Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page

[PMID:24713655-9] Sala, D et al. (2014) Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. J. Clin. Invest. 124 1914-27 PubMed GONUTS page

[PMID:24954904-10] Dooley, HC et al. (2014) WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol. Cell 55 238-52 PubMed GONUTS page

[PMID:24035364-11] Bonilla, DL et al. (2013) Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity 39 537-47 PubMed GONUTS page

[PMID:10458914-12] Okazaki, M et al. (1999) Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. Genomics 60 87-95 PubMed GONUTS page

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