MOUSE:SMAD7

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Smad7 (synonyms: Madh7, Madh8)
Protein Name(s)	Mothers against decapentaplegic homolog 7 MAD homolog 7 Mothers against DPP homolog 7 Mothers against decapentaplegic homolog 8 MAD homolog 8 Mothers against DPP homolog 8 SMAD family member 7 SMAD 7 Smad7
External Links
UniProt	O35253
EMBL	AF015260 AJ000550 AJ000551
CCDS	CCDS37860.1
RefSeq	NP_001036125.1 XP_006525766.1
UniGene	Mm.34407
ProteinModelPortal	O35253
SMR	O35253
BioGrid	201280
IntAct	O35253
MINT	MINT-261918
PhosphoSite	O35253
PRIDE	O35253
Ensembl	ENSMUST00000026999 ENSMUST00000168918
GeneID	17131
KEGG	mmu:17131
UCSC	uc008fqd.1 uc008fqe.2
CTD	4092
MGI	MGI:1100518
eggNOG	NOG309572
GeneTree	ENSGT00760000119091
HOGENOM	HOG000060106
HOVERGEN	HBG053021
InParanoid	O35253
KO	K04677
OMA	GQLCSEN
OrthoDB	EOG7GN2PK
PhylomeDB	O35253
TreeFam	TF314923
Reactome	REACT_203903 REACT_215733 REACT_220505
ChiTaRS	Smad7
NextBio	291328
PRO	PR:O35253
Proteomes	UP000000589
Bgee	O35253
CleanEx	MM_SMAD7
ExpressionAtlas	O35253
Genevestigator	O35253
GO	GO:0016342 GO:0005913 GO:0005829 GO:0005654 GO:0005634 GO:0043234 GO:0005667 GO:0005518 GO:0046872 GO:0003700 GO:0044212 GO:0030617 GO:0034333 GO:0048844 GO:0034629 GO:0071560 GO:0030514 GO:0060394 GO:0033137 GO:0010801 GO:0043433 GO:0010944 GO:0000122 GO:0030512 GO:0051444 GO:0060389 GO:0022409 GO:0032436 GO:0031398 GO:0050821 GO:0032925 GO:0055117 GO:0017015 GO:0060373 GO:0034616 GO:0006351 GO:0007179 GO:0001657 GO:0055010 GO:0060412
Gene3D	2.60.200.10 3.90.520.10
InterPro	IPR013790 IPR003619 IPR013019 IPR017855 IPR001132 IPR008984
PANTHER	PTHR13703
Pfam	PF03165 PF03166
SMART	SM00523 SM00524
SUPFAM	SSF49879 SSF56366
PROSITE	PS51075 PS51076

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000317	negative regulation of T-helper 17 type immune response	PMID:25642768^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002725	negative regulation of T cell cytokine production	PMID:25642768^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000492) has_regulation_target:(UniProtKB:Q62386)	Seeded From UniProt	complete
involved_in	GO:2000320	negative regulation of T-helper 17 cell differentiation	PMID:25642768^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000492)	Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	PMID:18952608^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:18952608^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization	PMID:18952608^[3]	ECO:0000305	curator inference used in manual assertion	GO:0055010	P		Seeded From UniProt	complete
involved_in	GO:0055117	regulation of cardiac muscle contraction	PMID:18952608^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	PMID:18952608^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0030279	negative regulation of ossification	PMID:29503843^[4]	ECO:0000314			P		Fig;4 A-c shows that mineral is significantly decreased with BMP2 and SMAD7 compared to the control of just BMP2. Organism: Mouse	complete CACAO 13213
involved_in	GO:0048844	artery morphogenesis	PMID:18952608^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:1903043	positive regulation of chondrocyte hypertrophy	PMID:29503843^[4]	ECO:0000314			P		“overexpression of Smad7 led to a significant expansion of the hypertrophic chondrocyte zone,” compared to just BMP2 Figure 5AB Organism: Mouse	complete CACAO 13206
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q02248)	Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:1902731	negative regulation of chondrocyte proliferation	PMID:29503843^[4]	ECO:0000314			P		“overexpression of Smad7 led to decreasing the proliferating chondrocyte zone” compared to just BMP2 (Figure 5Bb) Organism: Mouse	complete CACAO 13208
involved_in	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	PMID:18952608^[3]	ECO:0000305	curator inference used in manual assertion	GO:0060389	P		Seeded From UniProt	complete
involved_in	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	PMID:18593713^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q02248)	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:14656760^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051444	negative regulation of ubiquitin-protein transferase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69314	P		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034629	cellular protein-containing complex localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034333	adherens junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16601693^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23610558^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032925	regulation of activin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69314	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
enables	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	PMID:19850029^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022409	positive regulation of cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:69314	P		Seeded From UniProt	complete
colocalizes_with	GO:0016342	catenin complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:11557747^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005913	cell-cell adherens junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16601693^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	PMID:14559231^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08121 UniProtKB:Q01149 UniProtKB:Q3U962	F		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15105	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
involved_in	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0048185	activin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0034713	type I transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
involved_in	GO:0034629	cellular protein-containing complex localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0034616	response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0034333	adherens junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
involved_in	GO:0032925	regulation of activin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0031397	negative regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
involved_in	GO:0030514	negative regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0022409	positive regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
part_of	GO:0016342	catenin complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
involved_in	GO:0010944	negative regulation of transcription by competitive promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	F		Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
part_of	GO:0001650	fibrillar center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15105 ensembl:ENSP00000262158	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001132 InterPro:IPR003619 InterPro:IPR013019 InterPro:IPR013790	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013019 InterPro:IPR036578	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-2179313 Reactome:R-NUL-2179307 Reactome:R-NUL-2176431 Reactome:R-NUL-2176428 Reactome:R-NUL-2176427 Reactome:R-NUL-2176396 Reactome:R-NUL-2176393 Reactome:R-NUL-2169043 Reactome:R-NUL-2169036 Reactome:R-NUL-2169016 Reactome:R-NUL-2167890 Reactome:R-NUL-2167888 Reactome:R-NUL-2167872	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-2186775 Reactome:R-NUL-2176430 Reactome:R-NUL-2176428 Reactome:R-NUL-2169016 Reactome:R-NUL-2169012 Reactome:R-NUL-2169004 Reactome:R-NUL-2167888	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Murugaiyan, G et al. (2015) MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest. 125 1069-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Chen, Q et al. (2009) Smad7 is required for the development and function of the heart. J. Biol. Chem. 284 292-300 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhao, C et al. (2017) Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis 4 229-239 PubMed GONUTS page
↑ Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^7.0 ^7.1 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page
↑ Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page
↑ Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page
↑ Ito, Y et al. (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J. Biol. Chem. 276 44163-72 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page

[PMID:25642768-1] 1.0 ^1.1 ^1.2 Murugaiyan, G et al. (2015) MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest. 125 1069-80 PubMed GONUTS page

[PMID:18593713-2] 2.0 ^2.1 ^2.2 ^2.3 Tang, Y et al. (2008) Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J. Biol. Chem. 283 23956-63 PubMed GONUTS page

[PMID:18952608-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Chen, Q et al. (2009) Smad7 is required for the development and function of the heart. J. Biol. Chem. 284 292-300 PubMed GONUTS page

[PMID:29503843-4] 4.0 ^4.1 ^4.2 Zhao, C et al. (2017) Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis 4 229-239 PubMed GONUTS page

[PMID:14656760-5] Vrljicak, P et al. (2004) Smad expression during kidney development. Am. J. Physiol. Renal Physiol. 286 F625-33 PubMed GONUTS page

[PMID:20439489-6] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:16601693-7] 7.0 ^7.1 Liu, W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J. 25 1646-58 PubMed GONUTS page

[PMID:23610558-8] Kelly, CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol. 11 e1001538 PubMed GONUTS page

[PMID:19850029-9] Misra, K & Matise, MP (2010) A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling. Dev. Biol. 337 74-83 PubMed GONUTS page

[PMID:11557747-10] Ito, Y et al. (2001) Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J. Biol. Chem. 276 44163-72 PubMed GONUTS page

[PMID:19796622-11] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:14559231-12] Ellis, LR et al. (2003) Interaction of Smads with collagen types I, III, and V. Biochem. Biophys. Res. Commun. 310 1117-23 PubMed GONUTS page

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