MOUSE:PTPRO

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ptpro (synonyms: GLEPP1, Ptpn15, PTPU2)
Protein Name(s)	Receptor-type tyrosine-protein phosphatase O R-PTP-O Glomerular epithelial protein 1 Protein tyrosine phosphatase U2 PTP-U2 PTPase U2
External Links
UniProt	E9Q612
EMBL	AC093120 AC144767 AC163627 BC052743
CCDS	CCDS20664.1
RefSeq	NP_035346.3
UniGene	Mm.186361 Mm.491536
ProteinModelPortal	E9Q612
SMR	E9Q612
IntAct	E9Q612
STRING	10090.ENSMUSP00000076364
iPTMnet	E9Q612
PhosphoSitePlus	E9Q612
MaxQB	E9Q612
PaxDb	E9Q612
PRIDE	E9Q612
Ensembl	ENSMUST00000077115
GeneID	19277
KEGG	mmu:19277
UCSC	uc009emv.2
CTD	5800
MGI	MGI:1097152
eggNOG	KOG0791 COG5599
GeneTree	ENSGT00870000136384
HOGENOM	HOG000115792
HOVERGEN	HBG053763
InParanoid	E9Q612
KO	K18035
OMA	ISSGWPD
OrthoDB	EOG091G00JF
TreeFam	TF351926
PRO	PR:E9Q612
Proteomes	UP000000589
Bgee	ENSMUSG00000030223
ExpressionAtlas	E9Q612
Genevisible	E9Q612
GO	GO:0016324 GO:0043197 GO:0070062 GO:0016021 GO:0016328 GO:0005886 GO:0042803 GO:0004725 GO:0017147 GO:0007411 GO:0000902 GO:0072112 GO:0032835 GO:0030032 GO:0002548 GO:0090090 GO:0003105 GO:0035335 GO:0003093 GO:0036060
CDD	cd00063
Gene3D	2.60.40.10 3.90.190.10
InterPro	IPR003961 IPR013783 IPR029021 IPR000242 IPR016130 IPR003595 IPR000387
Pfam	PF00041 PF00102
PRINTS	PR00700
SMART	SM00060 SM00194 SM00404
SUPFAM	SSF49265 SSF52799
PROSITE	PS50853 PS00383 PS50056 PS50055

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:26063811^[1]	ECO:0000314			P		Figure 1B: mouse Ptpro dephosphorylates tyrosine-phosphorylated IR in vitro	complete CACAO 12415
	GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	PMID:26063811^[1]	ECO:0000314			P		Figure 2B and 2C: mouse Ptpro dephosphorylates tyrosine 1146 in the activation loop of the insulin receptor (a member of the receptor protein tyrosine kinase superfamily) in HEK293T (human embryonic kidney) cells	complete CACAO 12416
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:20804755^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	PMID:11086029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:19924828^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19573017^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0036060	slit diaphragm assembly	PMID:11086029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	PMID:15673668^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
involved_in	GO:0030032	lamellipodium assembly	PMID:20398064^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:20804755^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	PMID:20633639^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:20633639^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000653)	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:19800005^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15673668^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	PMID:15673668^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62797	P		Seeded From UniProt	complete
involved_in	GO:0003093	regulation of glomerular filtration	PMID:11086029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	PMID:20398064^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:28871037^[10]	ECO:0006042	cell fractionation evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:28871037^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:28871037^[10]	ECO:0000279	western blot evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:28871037^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:28871037^[10]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:28871037^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:28871037^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:28871037^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:28871037^[10]	ECO:0006052	RNAi evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:28871037^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:28871037^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006052	RNAi evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050807	regulation of synapse organization	PMID:28871037^[10]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032835	glomerulus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16827	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62068	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62068	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002548	monocyte chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16827	P		Seeded From UniProt	complete
involved_in	GO:0035335	peptidyl-tyrosine dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16827 ensembl:ENSP00000281171	P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16827 ensembl:ENSP00000281171	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16827 ensembl:ENSP00000281171	F		Seeded From UniProt	complete
involved_in	GO:0002548	monocyte chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16827 ensembl:ENSP00000281171	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62797 ensembl:ENSRNOP00000044055	F		Seeded From UniProt	complete
involved_in	GO:0003105	negative regulation of glomerular filtration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62797 ensembl:ENSRNOP00000044055	P		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242 InterPro:IPR016130	F		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000242	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387 InterPro:IPR016130	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000387	F		Seeded From UniProt	complete
enables	GO:0004725	protein tyrosine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.48	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0904	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page
↑ ^2.0 ^2.1 Kim, M et al. (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett. 584 3923-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wharram, BL et al. (2000) Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J. Clin. Invest. 106 1281-90 PubMed GONUTS page
↑ Kotani, T et al. (2010) Expression of PTPRO in the interneurons of adult mouse olfactory bulb. J. Comp. Neurol. 518 119-36 PubMed GONUTS page
↑ Hower, AE et al. (2009) Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J. Neurochem. 110 1635-47 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Chen, B & Bixby, JL (2005) A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth. J. Neurosci. 25 880-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Murata, Y et al. (2010) Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells 15 513-24 PubMed GONUTS page
↑ ^8.0 ^8.1 Matozaki, T et al. (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell. Signal. 22 1811-7 PubMed GONUTS page
↑ Gonzalez-Brito, MR & Bixby, JL (2009) Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system. Mol. Cell. Neurosci. 42 458-65 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 Jiang, W et al. (2017) Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation. J. Neurosci. 37 9828-9843 PubMed GONUTS page

[PMID:26063811-1] 1.0 ^1.1 Shintani, T et al. (2015) The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158 235-43 PubMed GONUTS page

[PMID:20804755-2] 2.0 ^2.1 Kim, M et al. (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett. 584 3923-8 PubMed GONUTS page

[PMID:11086029-3] 3.0 ^3.1 ^3.2 Wharram, BL et al. (2000) Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J. Clin. Invest. 106 1281-90 PubMed GONUTS page

[PMID:19924828-4] Kotani, T et al. (2010) Expression of PTPRO in the interneurons of adult mouse olfactory bulb. J. Comp. Neurol. 518 119-36 PubMed GONUTS page

[PMID:19573017-5] Hower, AE et al. (2009) Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC. J. Neurochem. 110 1635-47 PubMed GONUTS page

[PMID:15673668-6] 6.0 ^6.1 ^6.2 Chen, B & Bixby, JL (2005) A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth. J. Neurosci. 25 880-8 PubMed GONUTS page

[PMID:20398064-7] 7.0 ^7.1 Murata, Y et al. (2010) Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn. Genes Cells 15 513-24 PubMed GONUTS page

[PMID:20633639-8] 8.0 ^8.1 Matozaki, T et al. (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell. Signal. 22 1811-7 PubMed GONUTS page

[PMID:19800005-9] Gonzalez-Brito, MR & Bixby, JL (2009) Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system. Mol. Cell. Neurosci. 42 458-65 PubMed GONUTS page

[PMID:28871037-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 ^10.17 ^10.18 Jiang, W et al. (2017) Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation. J. Neurosci. 37 9828-9843 PubMed GONUTS page

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MOUSE:PTPRO

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