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Gonzalez-Brito, MR and Bixby, JL (2009) Protein tyrosine phosphatase receptor type O regulates development and function of the sensory nervous system. Mol. Cell. Neurosci. 42:458-65


The roles of protein tyrosine phosphatases (PTPs) in differentiation and axon targeting by dorsal root ganglion (DRG) neurons are essentially unknown. The type III transmembrane PTP, PTPRO, is expressed in DRG neurons, and is implicated in the guidance of motor and retinal axons. We examined the role of PTPRO in DRG development and function using PTPRO(-/-) mice. The number of peptidergic nociceptive neurons in the DRG of PTPRO(-/-) mice was significantly decreased, while the total number of sensory neurons appeared unchanged. In addition, spinal pathfinding by both peptidergic and proprioceptive neurons was abnormal in PTPRO(-/-) mice. Lastly, PTPRO(-/-) mice performed abnormally on tests of thermal pain and sensorimotor coordination, suggesting that both nociception and proprioception were perturbed. Our data indicate that PTPRO is required for peptidergic differentiation and process outgrowth of sensory neurons, as well as mature sensory function, and provide the first evidence that RPTPs regulate DRG development.


PubMed PMC2783383 Online version:10.1016/j.mcn.2009.09.009


Animals; Behavior, Animal/physiology; Ganglia, Spinal/cytology; Ganglia, Spinal/growth & development; Ganglia, Spinal/physiology; Mice; Mice, Knockout; Neural Pathways/abnormalities; Neural Pathways/anatomy & histology; Neural Pathways/physiology; Pain/metabolism; Pain Measurement; Receptor-Like Protein Tyrosine Phosphatases, Class 3/genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism; Sensory Receptor Cells/cytology; Sensory Receptor Cells/physiology; Spinal Cord/cytology; Spinal Cord/metabolism



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt


See also


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