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PMID:20804755

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Citation

Kim, M, Kim, H and Jho, EH (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett. 584:3923-8

Abstract

Wnt/β-catenin signaling plays critical roles in embryonic development and tissue homeostasis in adults by controlling the expression of target genes. We found that expression of ptpro, which encodes a protein tyrosine phosphatase receptor type O (PTPRO), was induced by Wnt/β-catenin signaling in a T cell factor/lymphoid enhancer factor dependent manner. Biochemical assays found that PTPRO interacted with Wnt via its extracellular domain. In addition, ectopic expression of this extracellular domain inhibited Wnt-mediated reporter activity. These results suggest that ptpro is a target gene of Wnt/β-catenin signaling and that PTPRO may function as a novel receptor for Wnt.

Links

PubMed Online version:10.1016/j.febslet.2010.08.034

Keywords

Animals; Cell Line; Cell Line, Tumor; Gene Expression Regulation; Humans; Lymphoid Enhancer-Binding Factor 1/metabolism; Mice; Receptor-Like Protein Tyrosine Phosphatases, Class 3/genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism; Signal Transduction; TCF Transcription Factors/metabolism; Wnt Proteins/metabolism; beta Catenin/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PTPRO

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P27467

F

Seeded From UniProt

complete

MOUSE:WNT3A

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:E9Q612

F

Seeded From UniProt

complete

MOUSE:PTPRO

enables

GO:0017147: Wnt-protein binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:PTPRO

involved_in

GO:0090090: negative regulation of canonical Wnt signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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