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PMID:20633639

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Citation

Matozaki, T, Murata, Y, Mori, M, Kotani, T, Okazawa, H and Ohnishi, H (2010) Expression, localization, and biological function of the R3 subtype of receptor-type protein tyrosine phosphatases in mammals. Cell. Signal. 22:1811-7

Abstract

The R3 subtype of receptor-type protein tyrosine phosphatases (RPTPs) includes VE-PTP, DEP-1, PTPRO, and SAP-1. All of these enzymes share a similar structure, with a single catalytic domain and putative tyrosine phosphorylation sites in the cytoplasmic region and fibronectin type III-like domains in the extracellular region. The expression of each R3 RPTP is largely restricted to a single or limited number of cell types, with VE-PTP and DEP-1 being expressed in endothelial or hematopoietic cells, PTPRO in neurons and in podocytes of the renal glomerulus, and SAP-1 in gastrointestinal epithelial cells. In addition, these RPTPs are localized specifically at the apical surface of polarized cells. The structure, expression, and localization of the R3 RPTPs suggest that they perform tissue-specific functions and that they might act through a common mechanism that includes activation of Src family kinases. In this review, we describe recent insights into R3-subtype RPTPs, particularly those of mammals.

Links

PubMed Online version:10.1016/j.cellsig.2010.07.001

Keywords

Animals; Catalytic Domain; Endothelial Cells/metabolism; Fibronectins/metabolism; Mammals/metabolism; Neurons/metabolism; Protein Structure, Tertiary; Receptor-Like Protein Tyrosine Phosphatases, Class 3/metabolism; Receptor-Like Protein Tyrosine Phosphatases, Class 3/physiology; src-Family Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PTPRO

located_in

GO:0016328: lateral plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000653)

Seeded From UniProt

complete

MOUSE:PTPRO

located_in

GO:0016324: apical plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000653)

Seeded From UniProt

complete

HUMAN:PTPRO

involved_in

GO:0036060: slit diaphragm assembly

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

MOUSE:PTPRO

part_of

GO:0016324: apical plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000653)

Seeded From UniProt

complete

MOUSE:PTPRO

part_of

GO:0016328: lateral plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000653)

Seeded From UniProt

complete


See also

References

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