MOUSE:PGFRA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pdgfra
Protein Name(s)	Platelet-derived growth factor receptor alpha PDGF-R-alpha PDGFR-alpha Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A Platelet-derived growth factor alpha receptor
External Links
UniProt	P26618
EMBL	M57683 M84607 AK081664 AK136490 AK147267 AK163952 BC053036
CCDS	CCDS19351.1
PIR	I57511
RefSeq	NP_001076785.1 NP_035188.2 XP_006504324.1 XP_006504325.1 XP_006504326.1
UniGene	Mm.221403
ProteinModelPortal	P26618
SMR	P26618
BioGrid	202088
IntAct	P26618
MINT	MINT-4107325
BindingDB	P26618
ChEMBL	CHEMBL2096980
GuidetoPHARMACOLOGY	1803
PhosphoSite	P26618
PaxDb	P26618
PRIDE	P26618
Ensembl	ENSMUST00000000476 ENSMUST00000168162
GeneID	18595
KEGG	mmu:18595
UCSC	uc008xub.1 uc008xuc.1
CTD	5156
MGI	MGI:97530
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000112009
HOVERGEN	HBG004335
InParanoid	P26618
KO	K04363
OMA	YECAARQ
OrthoDB	EOG71G9T1
PhylomeDB	P26618
TreeFam	TF325768
BRENDA	2.7.10.1
Reactome	REACT_196588 REACT_226341 REACT_230639 REACT_263353
ChiTaRS	Pdgfra
NextBio	294480
PRO	PR:P26618
Proteomes	UP000000589
Bgee	P26618
ExpressionAtlas	P26618
Genevestigator	P26618
GO	GO:0009986 GO:0005737 GO:0009897 GO:0005887 GO:0005902 GO:0005634 GO:0005524 GO:0005018 GO:0048407 GO:0032403 GO:0042803 GO:0005021 GO:0030325 GO:0009653 GO:0055003 GO:0060326 GO:0016477 GO:0071230 GO:0048701 GO:0048557 GO:0008210 GO:0030198 GO:0060325 GO:0008585 GO:0002244 GO:0001701 GO:0033327 GO:0030324 GO:0001553 GO:0030539 GO:0072277 GO:0010544 GO:0042475 GO:0009887 GO:0060021 GO:0018108 GO:0048015 GO:0070527 GO:0048008 GO:0035790 GO:0030335 GO:0008284 GO:0038091 GO:0007204 GO:0045740 GO:0070374 GO:0048146 GO:0043552 GO:0010863 GO:0046777 GO:0050920 GO:2000739 GO:0061298 GO:0023019 GO:0048705 GO:0042060
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR013098 IPR003599 IPR003598 IPR011009 IPR027290 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR016243 IPR001824
PANTHER	PTHR24416:SF52
Pfam	PF07679 PF07714
PIRSF	PIRSF500950 PIRSF000615
SMART	SM00409 SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109 PS00240

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005929	cilium	PMID:29237719^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:29237719^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:22265737^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000739	regulation of mesenchymal stem cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0072277	metanephric glomerular capillary formation	PMID:11239463^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05622	P		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	PMID:11239463^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05622	P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	PMID:20110689^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055003	cardiac myofibril assembly	PMID:11239463^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05622	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:9226440^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	PMID:10903171^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:20110689^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:20110689^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:20110689^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	PMID:20110689^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:20110689^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:20110689^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010544	negative regulation of platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20786	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20786	C		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	PMID:20110689^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P20786	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:97531 PANTHER:PTN001230896 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97530 PANTHER:PTN002814370 UniProtKB:P16234	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 MGI:MGI:1339758 MGI:MGI:96677 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1339758 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:97531 PANTHER:PTN001230896 RGD:2621 RGD:2965 RGD:3284 RGD:3285 RGD:620568 UniProtKB:P07333 UniProtKB:P09619 UniProtKB:P16234 UniProtKB:P35916 UniProtKB:P35968	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97530 PANTHER:PTN002814370 RGD:3284 UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95559 MGI:MGI:96677 MGI:MGI:97530 PANTHER:PTN001230732	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000739	regulation of mesenchymal stem cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070527	platelet aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061047	positive regulation of branching involved in lung morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060437	lung growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060326	cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060325	face morphogenesis	PMID:17143286^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:17143286^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P	results_in_development_of:(EMAPA:18948)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050920	regulation of chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:17143286^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:15372073^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:17143286^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:23160237^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(GO:0034464)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:15543606^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034614	cellular response to reactive oxygen species	PMID:24190966^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033327	Leydig cell differentiation	PMID:19056881^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449440,MGI:MGI:3689423	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24190966^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030539	male genitalia development	PMID:12651897^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926714	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030325	adrenal gland development	PMID:19056881^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97531	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:11803579^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030198	extracellular matrix organization	PMID:15543606^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010863	positive regulation of phospholipase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010544	negative regulation of platelet activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17350578^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:10806482^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009653	anatomical structure morphogenesis	PMID:15543606^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008585	female gonad development	PMID:19056881^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008210	estrogen metabolic process	PMID:19056881^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:23266329^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22027834^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21146513^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3284	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:24190966^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002244	hematopoietic progenitor cell differentiation	PMID:24029230^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17143286^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:10331973^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1926728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001553	luteinization	PMID:19056881^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1914283	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001553	luteinization	PMID:19056881^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449440,MGI:MGI:3689423	P		Seeded From UniProt	complete
involved_in	GO:2000739	regulation of mesenchymal stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0060326	cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0050920	regulation of chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
involved_in	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0010863	positive regulation of phospholipase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0010544	negative regulation of platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16234 ensembl:ENSP00000257290	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	F		Seeded From UniProt	complete
enables	GO:0005018	platelet-derived growth factor alpha-receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027290	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001824 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR001824 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001824	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027290	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0048407	platelet-derived growth factor binding	PMID:20299672^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Schmid, FM et al. (2018) IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases. J. Cell Biol. 217 151-161 PubMed GONUTS page
↑ Pereira, LA et al. (2012) Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells. Stem Cell Res 8 165-79 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Klinghoffer, RA et al. (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol. Cell 7 343-54 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Schneider, L et al. (2010) Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell. Physiol. Biochem. 25 279-92 PubMed GONUTS page
↑ Soriano, P (1997) The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124 2691-700 PubMed GONUTS page
↑ Karlsson, L et al. (2000) Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127 3457-66 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Schmahl, J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39 52-60 PubMed GONUTS page
↑ Fredriksson, L et al. (2004) Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23 3793-802 PubMed GONUTS page
↑ Carter, CS et al. (2012) Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat. Med. 18 1797-804 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Xu, X et al. (2005) PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev. Dyn. 232 75-84 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Lei, H & Kazlauskas, A (2014) A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol. Cell. Biol. 34 110-22 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Schmahl, J et al. (2008) The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 22 3255-67 PubMed GONUTS page
↑ Brennan, J et al. (2003) Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 17 800-10 PubMed GONUTS page
↑ Boström, H et al. (2002) PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev. Dyn. 223 155-62 PubMed GONUTS page
↑ Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page
↑ Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page
↑ Li, X et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2 302-9 PubMed GONUTS page
↑ Bell, SM et al. (2013) Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev. Biol. 375 128-39 PubMed GONUTS page
↑ Fukumoto, Y et al. (2011) Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J. Biol. Chem. 286 43537-48 PubMed GONUTS page
↑ Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page
↑ Nagamachi, A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell 24 305-17 PubMed GONUTS page
↑ Karlsson, L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126 2611-21 PubMed GONUTS page
↑ Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:29237719-1] 1.0 ^1.1 Schmid, FM et al. (2018) IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases. J. Cell Biol. 217 151-161 PubMed GONUTS page

[PMID:22265737-2] Pereira, LA et al. (2012) Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells. Stem Cell Res 8 165-79 PubMed GONUTS page

[PMID:11239463-3] 3.0 ^3.1 ^3.2 Klinghoffer, RA et al. (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol. Cell 7 343-54 PubMed GONUTS page

[PMID:20110689-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Schneider, L et al. (2010) Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell. Physiol. Biochem. 25 279-92 PubMed GONUTS page

[PMID:9226440-5] Soriano, P (1997) The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development 124 2691-700 PubMed GONUTS page

[PMID:10903171-6] Karlsson, L et al. (2000) Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127 3457-66 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20548288-8] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:17143286-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Schmahl, J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39 52-60 PubMed GONUTS page

[PMID:15372073-10] Fredriksson, L et al. (2004) Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23 3793-802 PubMed GONUTS page

[PMID:23160237-11] Carter, CS et al. (2012) Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat. Med. 18 1797-804 PubMed GONUTS page

[PMID:15543606-12] 12.0 ^12.1 ^12.2 Xu, X et al. (2005) PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev. Dyn. 232 75-84 PubMed GONUTS page

[PMID:24190966-13] 13.0 ^13.1 ^13.2 Lei, H & Kazlauskas, A (2014) A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol. Cell. Biol. 34 110-22 PubMed GONUTS page

[PMID:19056881-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Schmahl, J et al. (2008) The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 22 3255-67 PubMed GONUTS page

[PMID:12651897-15] Brennan, J et al. (2003) Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev. 17 800-10 PubMed GONUTS page

[PMID:11803579-16] Boström, H et al. (2002) PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev. Dyn. 223 155-62 PubMed GONUTS page

[PMID:18462699-17] Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page

[PMID:17350578-18] Prall, OW et al. (2007) An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128 947-59 PubMed GONUTS page

[PMID:10806482-19] Li, X et al. (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2 302-9 PubMed GONUTS page

[PMID:23266329-20] Bell, SM et al. (2013) Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev. Biol. 375 128-39 PubMed GONUTS page

[PMID:22027834-21] Fukumoto, Y et al. (2011) Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J. Biol. Chem. 286 43537-48 PubMed GONUTS page

[PMID:21146513-22] Artus, J et al. (2011) The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev. Biol. 350 393-404 PubMed GONUTS page

[PMID:24029230-23] Nagamachi, A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell 24 305-17 PubMed GONUTS page

[PMID:10331973-24] Karlsson, L et al. (1999) Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development 126 2611-21 PubMed GONUTS page

[PMID:20299672-25] Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

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