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PMID:10806482
| Citation |
Li, X, Pontén, A, Aase, K, Karlsson, L, Abramsson, A, Uutela, M, Bäckström, G, Hellström, M, Boström, H, Li, H, Soriano, P, Betsholtz, C, Heldin, CH, Alitalo, K, Ostman, A and Eriksson, U (2000) PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat. Cell Biol. 2:302-9 |
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| Abstract |
Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function. |
| Links |
PubMed Online version:10.1038/35010579 |
| Keywords |
Animals; COS Cells; Endopeptidases/metabolism; Epithelial Cells/chemistry; Epithelial Cells/enzymology; Gene Expression/physiology; Gene Expression Regulation, Developmental; Humans; In Situ Hybridization; Insects; Kidney/chemistry; Kidney/embryology; Kidney/enzymology; Ligands; Lymphokines; Mesoderm/chemistry; Mesoderm/enzymology; Mice; Molecular Sequence Data; Myocardium/chemistry; Myocardium/enzymology; Platelet-Derived Growth Factor/chemistry; Platelet-Derived Growth Factor/genetics; Platelet-Derived Growth Factor/metabolism; Platelet-Derived Growth Factor/pharmacology; Protein Structure, Tertiary; RNA, Messenger/analysis; Rabbits; Receptor, Platelet-Derived Growth Factor alpha/metabolism; Sequence Homology, Amino Acid; Transgenes/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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