MOUSE:PAX6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pax6 (synonyms: Pax-6, Sey)
Protein Name(s)	Paired box protein Pax-6 Oculorhombin
External Links
UniProt	P63015
EMBL	X63963 X63963 Y19196 Y19199 AK028059 AK139054 BC011272 BC036957 M77842
CCDS	CCDS16499.1 CCDS57181.1
PIR	S42234
RefSeq	NP_001231127.1 NP_001231129.1 NP_001231130.1 NP_001231131.1 NP_038655.1 XP_006498976.1 XP_006498977.1 XP_006498978.1 XP_006498979.1 XP_006498980.1
UniGene	Mm.33870 Mm.3608 Mm.487124
ProteinModelPortal	P63015
SMR	P63015
BioGrid	202033
DIP	DIP-38879N
IntAct	P63015
MINT	MINT-1782085
PhosphoSite	P63015
MaxQB	P63015
PRIDE	P63015
Ensembl	ENSMUST00000090391 ENSMUST00000090397 ENSMUST00000111082 ENSMUST00000111083 ENSMUST00000111085 ENSMUST00000111086 ENSMUST00000111087 ENSMUST00000167211
GeneID	18508
KEGG	mmu:18508
UCSC	uc008lkv.2
CTD	5080
MGI	MGI:97490
eggNOG	NOG326044
GeneTree	ENSGT00680000099553
HOVERGEN	HBG009115
InParanoid	P63015
KO	K08031
OMA	QATWESG
OrthoDB	EOG7WT431
TreeFam	TF320146
Reactome	REACT_253751 REACT_259776
ChiTaRS	Pax6
NextBio	294236
PRO	PR:P63015
Proteomes	UP000000589
Bgee	P63015
CleanEx	MM_PAX6
ExpressionAtlas	P63015
Genevestigator	P63015
GO	GO:0005737 GO:0005622 GO:0000790 GO:0005634 GO:0005667 GO:0003680 GO:0003682 GO:0070410 GO:0003677 GO:0003690 GO:0035035 GO:0071837 GO:0019901 GO:0070412 GO:0000978 GO:0001077 GO:0000979 GO:0001227 GO:0001228 GO:0043565 GO:0000981 GO:0003700 GO:0008134 GO:0044212 GO:0031625 GO:0009952 GO:0048708 GO:0007411 GO:0007409 GO:0001568 GO:0007420 GO:0043010 GO:0030154 GO:0045165 GO:0001709 GO:0035690 GO:0044344 GO:0071333 GO:0032869 GO:0071380 GO:0021549 GO:0021796 GO:0021902 GO:0061303 GO:0009950 GO:0009953 GO:0048596 GO:0000132 GO:0042462 GO:0021797 GO:0030900 GO:0021798 GO:0021905 GO:1901142 GO:0022027 GO:0061072 GO:0030216 GO:0032808 GO:0002088 GO:0008285 GO:0050680 GO:2000178 GO:0045665 GO:0001933 GO:0000122 GO:0001755 GO:0001764 GO:0021772 GO:0021778 GO:0021543 GO:0003322 GO:0021983 GO:0042660 GO:0030858 GO:0010628 GO:0070094 GO:0002052 GO:2001224 GO:0045944 GO:0045893 GO:0033365 GO:0009786 GO:0030334 GO:0010468 GO:0050767 GO:0010975 GO:0048505 GO:0006357 GO:0021918 GO:0021912 GO:0021913 GO:0006355 GO:0045471 GO:0009611 GO:0060041 GO:0021593 GO:0007435 GO:0023019 GO:0007224 GO:0021978 GO:0006366 GO:0003309
Gene3D	1.10.10.10 1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057 IPR001523 IPR011991
Pfam	PF00046 PF00292
PRINTS	PR00027
SMART	SM00389 SM00351
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS00034 PS51057

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:17064680^[1]	ECO:0000315			P		Fig 6c+e	complete
	GO:0042462	eye photoreceptor cell development	PMID:10662634^[2]	ECO:0000315			P		fig. 1, fig .2, fig .3, fig .4, table 1, table 2	complete CACAO 3592
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12756174^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:4286)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:12756174^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:12756174^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	PMID:17251190^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070410	co-SMAD binding	PMID:17251190^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16407227^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20592023^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	PMID:16407227^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:16407227^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20592023^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16407227^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:20592023^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003322	pancreatic A cell development	PMID:20592023^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:20592023^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:16407227^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20592023^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:16407227^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20592023^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	PMID:16582099^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O55170	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18628401^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99PQ2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001224	positive regulation of neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000178	negative regulation of neural precursor cell proliferation	PMID:23622063^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:17544)\|regulates_o_occurs_in:(EMAPA:17544)\|regulates_o_occurs_in:(EMAPA:17544)\|regulates_o_occurs_in:(EMAPA:17544)\|regulates_o_occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904937	sensory neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904798	positive regulation of core promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901142	insulin metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0120008	positive regulation of glutamatergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098598	learned vocalization behavior or vocal learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070094	positive regulation of glucagon secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061351	neural precursor cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061303	cornea development in camera-type eye	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061072	iris morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061034	olfactory bulb mitral cell layer development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060041	retina development in camera-type eye	PMID:19146846^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96785	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050767	regulation of neurogenesis	PMID:15548580^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521718	P	regulates_o_results_in_formation_of:(EMAPA:17544) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050767	regulation of neurogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050680	negative regulation of epithelial cell proliferation	PMID:16080917^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:17162)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048708	astrocyte differentiation	PMID:19258013^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:17585) results_in_acquisition_of_features_of:(CL:0000127)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048708	astrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048596	embryonic camera-type eye morphogenesis	PMID:18653562^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1306784	P	has_participant:(EMAPA:16198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048505	regulation of timing of cell differentiation	PMID:9828088^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23643363^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1915344	P	regulates_o_occurs_in:(CL:0000740) regulates_o_occurs_in:(CL:0000740)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19146846^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96785	P	has_regulation_target:(MGI:MGI:1341840)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19749747^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18287938^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:98364)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15905411^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:16950124^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	occurs_in:(EMAPA:16531) regulates_o_results_in_acquisition_of_features_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045664	regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15229646^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1100526	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15878992^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19521500^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23622063^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1277162) occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12183364^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108564	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12072567^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102764	P	results_in_development_of:(EMAPA:17163)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:16080917^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	results_in_development_of:(EMAPA:17162)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12756174^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934347	P	results_in_development_of:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:12648492^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:11069887^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934348	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:11062307^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1931308	P	results_in_development_of:(EMAPA:16198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042660	positive regulation of cell fate specification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042462	eye photoreceptor cell development	PMID:12648492^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033365	protein localization to organelle	PMID:16024294^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	PMID:10821755^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030902	hindbrain development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15758185^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	results_in_development_of:(EMAPA:17547)\|results_in_development_of:(EMAPA:32672)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15548580^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15514979^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	results_in_development_of:(EMAPA:16895)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030858	positive regulation of epithelial cell differentiation	PMID:16080917^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:17162) regulates_o_results_in_acquisition_of_features_of:(CL:0000160)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:18701439^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:16910) occurs_in:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:10409504^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	PMID:16080917^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:17162) results_in_acquisition_of_features_of:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:24528677^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:35386)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:15031110^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:18816) results_in_acquisition_of_features_of:(CL:0000170)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0023019	signal transduction involved in regulation of gene expression	PMID:18462699^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022027	interkinetic nuclear migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021986	habenula development	PMID:24528677^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:10588713^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155 MGI:MGI:1934347	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021978	telencephalon regionalization	PMID:18701439^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021918	regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment	PMID:9230312^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:16525) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification	PMID:9230312^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:16525) regulates_o_occurs_in:(CL:0000099)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification	PMID:9230312^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:16916) regulates_o_occurs_in:(CL:0000100)\|regulates_o_occurs_in:(EMAPA:16525) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021905	forebrain-midbrain boundary formation	PMID:9169845^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155 MGI:MGI:1856158	P	results_in_formation_of:(EMAPA:16640)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain	PMID:11124115^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:16910) results_in_commitment_to:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:24528677^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:18701439^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:11124115^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	has_participant:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:11050125^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	has_participant:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021796	cerebral cortex regionalization	PMID:23431145^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021796	cerebral cortex regionalization	PMID:12764040^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	has_participant:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021778	oligodendrocyte cell fate specification	PMID:9828088^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:17577) results_in_specification_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021772	olfactory bulb development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021593	rhombomere morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021543	pallium development	PMID:11124115^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:18799682^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:16039) has_regulation_target:(MGI:MGI:2151153)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:16919471^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88357)\|has_regulation_target:(MGI:MGI:101757)\|has_regulation_target:(MGI:MGI:107793)\|has_regulation_target:(MGI:MGI:98506)\|has_regulation_target:(MGI:MGI:2447063)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:12764040^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15878992^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:15548580^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155 MGI:MGI:2156741 MGI:MGI:3521718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15917450^[48]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95388	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:12196586^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009950	dorsal/ventral axis specification	PMID:10588713^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155 MGI:MGI:1934347	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009786	regulation of asymmetric cell division	PMID:22031545^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15548580^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3521718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007435	salivary gland morphogenesis	PMID:11731698^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	has_participant:(EMAPA:18814)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12196586^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:10409504^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:14586016^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:16895)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:11967891^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:15514979^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856158	P	occurs_in:(EMAPA:16895) occurs_in:(CL:0000117)\|occurs_in:(EMAPA:16895) occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:18590716^[54]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006366	transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19521500^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9230312^[40]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16525) part_of:(CL:0000100)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25100583^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24466353^[56]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23434913^[57]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22764048^[58]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17503)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19409883^[59]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16464444^[60]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16906)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14625556^[61]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12050133^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11209945^[63]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16896)\|part_of:(EMAPA:17536)\|part_of:(EMAPA:17540)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18287938^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23637604^[64]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1201683) occurs_in:(CL:0000047)\|has_direct_input(MGI:MGI:88586) occurs_in:(CL:0000047)\|has_direct_input(MGI:MGI:104636) occurs_in:(CL:0000047)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:19146846^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12756174^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003322	pancreatic A cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003322	pancreatic A cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003310	pancreatic A cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003309	type B pancreatic cell differentiation	PMID:22764048^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934347	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003309	type B pancreatic cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003002	regionalization	PMID:9169845^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155 MGI:MGI:1856158	P	has_participant:(EMAPA:16640)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003002	regionalization	PMID:24528677^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002088	lens development in camera-type eye	PMID:6877261^[65]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2156742	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002064	epithelial cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:18287938^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	PMID:16497297^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	regulates_o_has_input:(MGI:MGI:97874) regulates_o_occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:15758185^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:17547)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001709	cell fate determination	PMID:12756174^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934347	P	occurs_in:(EMAPA:16674) results_in_determination_of:(CL:0000529)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22031545^[50]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:22031545^[50]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:23622063^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:1277162)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P26367	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3258	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000132	establishment of mitotic spindle orientation	PMID:22031545^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856155	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001227	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1T0F8 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1T0F8 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
involved_in	GO:1904798	positive regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
enables	GO:0070412	R-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	F		Seeded From UniProt	complete
involved_in	GO:0061303	cornea development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
involved_in	GO:0003322	pancreatic A cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26367 ensembl:ENSP00000492024	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR001523 InterPro:IPR009057	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001523 InterPro:IPR017970	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21084637^[67]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88516)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-5619441	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:10197584^[68]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:10197584^[68]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10197584^[68]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Blixt, A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev. Biol. 302 218-29 PubMed GONUTS page
↑ Collinson, JM et al. (2000) Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127 945-56 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bäumer, N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130 2903-15 PubMed GONUTS page
↑ ^4.0 ^4.1 Grocott, T et al. (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res. 35 890-901 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Kim, EA et al. (2006) Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J. Biol. Chem. 281 7489-97 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gosmain, Y et al. (2010) Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J. Biol. Chem. 285 33381-93 PubMed GONUTS page
↑ Wissmüller, S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 34 1735-44 PubMed GONUTS page
↑ Tuoc, TC & Stoykova, A (2008) Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev. 22 1972-86 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Mi, D et al. (2013) Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron 78 269-84 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Tétreault, N et al. (2009) The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev. Biol. 327 541-50 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Haubst, N et al. (2004) Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131 6131-40 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Ramaesh, T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp. Eye Res. 81 224-35 PubMed GONUTS page
↑ Genethliou, N et al. (2009) Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem. Biophys. Res. Commun. 382 69-73 PubMed GONUTS page
↑ Chen, Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135 2939-48 PubMed GONUTS page
↑ ^16.0 ^16.1 Sun, T et al. (1998) Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol. Cell. Neurosci. 12 228-39 PubMed GONUTS page
↑ Tuoc, TC et al. (2013) Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Dev. Cell 25 256-69 PubMed GONUTS page
↑ Pinto, L et al. (2009) AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat. Neurosci. 12 1229-37 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Wen, J et al. (2008) Pax6 directly modulate Sox2 expression in the neural progenitor cells. Neuroreport 19 413-7 PubMed GONUTS page
↑ Mui, SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev. 19 1249-59 PubMed GONUTS page
↑ Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page
↑ Schuurmans, C et al. (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 23 2892-902 PubMed GONUTS page
↑ ^23.0 ^23.1 Kroll, TT & O'Leary, DD (2005) Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc. Natl. Acad. Sci. U.S.A. 102 7374-9 PubMed GONUTS page
↑ ^24.0 ^24.1 Sansom, SN et al. (2009) The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 5 e1000511 PubMed GONUTS page
↑ Zhang, X et al. (2002) Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 16 2097-107 PubMed GONUTS page
↑ Goudreau, G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc. Natl. Acad. Sci. U.S.A. 99 8719-24 PubMed GONUTS page
↑ ^27.0 ^27.1 Collinson, JM et al. (2003) The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. Dev. Biol. 255 303-12 PubMed GONUTS page
↑ Ashery-Padan, R et al. (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 14 2701-11 PubMed GONUTS page
↑ Lyon, MF et al. (2000) Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop). Mol. Vis. 6 199-203 PubMed GONUTS page
↑ Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page
↑ Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page
↑ ^32.0 ^32.1 Tole, S et al. (2005) Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. J. Neurosci. 25 2753-60 PubMed GONUTS page
↑ ^33.0 ^33.1 Nural, HF & Mastick, GS (2004) Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J. Comp. Neurol. 479 399-409 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Carney, RS et al. (2009) Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Cereb. Cortex 19 745-59 PubMed GONUTS page
↑ ^35.0 ^35.1 Engelkamp, D et al. (1999) Role of Pax6 in development of the cerebellar system. Development 126 3585-96 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 Chatterjee, M et al. (2014) Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biol. 12 13 PubMed GONUTS page
↑ Heller, RS et al. (2004) The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev. Biol. 268 123-34 PubMed GONUTS page
↑ Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page
↑ ^39.0 ^39.1 Kioussi, C et al. (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc. Natl. Acad. Sci. U.S.A. 96 14378-82 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Ericson, J et al. (1997) Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90 169-80 PubMed GONUTS page
↑ ^41.0 ^41.1 Mastick, GS et al. (1997) Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development 124 1985-97 PubMed GONUTS page
↑ ^42.0 ^42.1 ^42.2 Yun, K et al. (2001) Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development 128 193-205 PubMed GONUTS page
↑ Stoykova, A et al. (2000) Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J. Neurosci. 20 8042-50 PubMed GONUTS page
↑ Elsen, GE et al. (2013) The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc. Natl. Acad. Sci. U.S.A. 110 4081-6 PubMed GONUTS page
↑ ^45.0 ^45.1 Muzio, L & Mallamaci, A (2003) Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb. Cortex 13 641-7 PubMed GONUTS page
↑ Tucker, ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J. Neurosci. 28 9504-18 PubMed GONUTS page
↑ Li, H et al. (2006) Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol. Cell. Neurosci. 33 136-49 PubMed GONUTS page
↑ Kimura, J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J. Neurosci. 25 5097-108 PubMed GONUTS page
↑ ^49.0 ^49.1 Bishop, KM et al. (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J. Neurosci. 22 7627-38 PubMed GONUTS page
↑ ^50.0 ^50.1 ^50.2 ^50.3 Asami, M et al. (2011) The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development 138 5067-78 PubMed GONUTS page
↑ Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page
↑ Andrews, GL & Mastick, GS (2003) R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J. Neurosci. 23 9873-80 PubMed GONUTS page
↑ Hevner, RF et al. (2002) Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J. Comp. Neurol. 447 8-17 PubMed GONUTS page
↑ Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page
↑ Gil-Sanz, C et al. (2014) Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J. Neurosci. 34 10475-87 PubMed GONUTS page
↑ Kim, BJ & Scott, DA (2014) Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. PLoS ONE 9 e87518 PubMed GONUTS page
↑ Itoh, Y et al. (2013) Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. Nat. Neurosci. 16 416-25 PubMed GONUTS page
↑ ^58.0 ^58.1 Kredo-Russo, S et al. (2012) Pancreas-enriched miRNA refines endocrine cell differentiation. Development 139 3021-31 PubMed GONUTS page
↑ Okado, H et al. (2009) The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev. Biol. 331 140-51 PubMed GONUTS page
↑ Kim, J & Lauderdale, JD (2006) Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev. Biol. 292 486-505 PubMed GONUTS page
↑ Nishida, A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat. Neurosci. 6 1255-63 PubMed GONUTS page
↑ Zhu, CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129 2835-49 PubMed GONUTS page
↑ Wolf, LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12 329-33 PubMed GONUTS page
↑ Marakalala, MJ et al. (2013) Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog. 9 e1003315 PubMed GONUTS page
↑ Favor, J (1983) A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat. Res. 110 367-82 PubMed GONUTS page
↑ Sharp, P et al. (2006) Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function. Exp. Neurol. 198 511-8 PubMed GONUTS page
↑ Yan, Q et al. (2010) Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proc. Natl. Acad. Sci. U.S.A. 107 21034-9 PubMed GONUTS page
↑ ^68.0 ^68.1 ^68.2 Mansouri, A et al. (1999) Pax genes and their role in organogenesis. Cancer Res. 59 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page

[PMID:17064680-1] Blixt, A et al. (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev. Biol. 302 218-29 PubMed GONUTS page

[PMID:10662634-2] Collinson, JM et al. (2000) Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. Development 127 945-56 PubMed GONUTS page

[PMID:12756174-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Bäumer, N et al. (2003) Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development 130 2903-15 PubMed GONUTS page

[PMID:17251190-4] 4.0 ^4.1 Grocott, T et al. (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Res. 35 890-901 PubMed GONUTS page

[PMID:16407227-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Kim, EA et al. (2006) Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2. J. Biol. Chem. 281 7489-97 PubMed GONUTS page

[PMID:20592023-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gosmain, Y et al. (2010) Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. J. Biol. Chem. 285 33381-93 PubMed GONUTS page

[PMID:16582099-7] Wissmüller, S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res. 34 1735-44 PubMed GONUTS page

[PMID:18628401-8] Tuoc, TC & Stoykova, A (2008) Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes Dev. 22 1972-86 PubMed GONUTS page

[PMID:23622063-9] 9.0 ^9.1 ^9.2 Mi, D et al. (2013) Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb. Neuron 78 269-84 PubMed GONUTS page

[PMID:20439489-10] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:19146846-11] 11.0 ^11.1 ^11.2 Tétreault, N et al. (2009) The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. Dev. Biol. 327 541-50 PubMed GONUTS page

[PMID:15548580-12] 12.0 ^12.1 ^12.2 ^12.3 Haubst, N et al. (2004) Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development. Development 131 6131-40 PubMed GONUTS page

[PMID:16080917-13] 13.0 ^13.1 ^13.2 ^13.3 Ramaesh, T et al. (2005) Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia. Exp. Eye Res. 81 224-35 PubMed GONUTS page

[PMID:19258013-14] Genethliou, N et al. (2009) Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem. Biophys. Res. Commun. 382 69-73 PubMed GONUTS page

[PMID:18653562-15] Chen, Y et al. (2008) Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis. Development 135 2939-48 PubMed GONUTS page

[PMID:9828088-16] 16.0 ^16.1 Sun, T et al. (1998) Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol. Cell. Neurosci. 12 228-39 PubMed GONUTS page

[PMID:23643363-17] Tuoc, TC et al. (2013) Chromatin regulation by BAF170 controls cerebral cortical size and thickness. Dev. Cell 25 256-69 PubMed GONUTS page

[PMID:19749747-18] Pinto, L et al. (2009) AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat. Neurosci. 12 1229-37 PubMed GONUTS page

[PMID:18287938-19] 19.0 ^19.1 ^19.2 Wen, J et al. (2008) Pax6 directly modulate Sox2 expression in the neural progenitor cells. Neuroreport 19 413-7 PubMed GONUTS page

[PMID:15905411-20] Mui, SH et al. (2005) Vax genes ventralize the embryonic eye. Genes Dev. 19 1249-59 PubMed GONUTS page

[PMID:16950124-21] Lei, Q et al. (2006) Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev. Cell 11 325-37 PubMed GONUTS page

[PMID:15229646-22] Schuurmans, C et al. (2004) Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. EMBO J. 23 2892-902 PubMed GONUTS page

[PMID:15878992-23] 23.0 ^23.1 Kroll, TT & O'Leary, DD (2005) Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc. Natl. Acad. Sci. U.S.A. 102 7374-9 PubMed GONUTS page

[PMID:19521500-24] 24.0 ^24.1 Sansom, SN et al. (2009) The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 5 e1000511 PubMed GONUTS page

[PMID:12183364-25] Zhang, X et al. (2002) Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 16 2097-107 PubMed GONUTS page

[PMID:12072567-26] Goudreau, G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc. Natl. Acad. Sci. U.S.A. 99 8719-24 PubMed GONUTS page

[PMID:12648492-27] 27.0 ^27.1 Collinson, JM et al. (2003) The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. Dev. Biol. 255 303-12 PubMed GONUTS page

[PMID:11069887-28] Ashery-Padan, R et al. (2000) Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 14 2701-11 PubMed GONUTS page

[PMID:11062307-29] Lyon, MF et al. (2000) Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop). Mol. Vis. 6 199-203 PubMed GONUTS page

[PMID:16024294-30] Purcell, P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr. Patterns 6 110-8 PubMed GONUTS page

[PMID:10821755-31] Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page

[PMID:15758185-32] 32.0 ^32.1 Tole, S et al. (2005) Selective requirement of Pax6, but not Emx2, in the specification and development of several nuclei of the amygdaloid complex. J. Neurosci. 25 2753-60 PubMed GONUTS page

[PMID:15514979-33] 33.0 ^33.1 Nural, HF & Mastick, GS (2004) Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. J. Comp. Neurol. 479 399-409 PubMed GONUTS page

[PMID:18701439-34] 34.0 ^34.1 ^34.2 Carney, RS et al. (2009) Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. Cereb. Cortex 19 745-59 PubMed GONUTS page

[PMID:10409504-35] 35.0 ^35.1 Engelkamp, D et al. (1999) Role of Pax6 in development of the cerebellar system. Development 126 3585-96 PubMed GONUTS page

[PMID:24528677-36] 36.0 ^36.1 ^36.2 ^36.3 Chatterjee, M et al. (2014) Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biol. 12 13 PubMed GONUTS page

[PMID:15031110-37] Heller, RS et al. (2004) The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev. Biol. 268 123-34 PubMed GONUTS page

[PMID:18462699-38] Lee, D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2 497-507 PubMed GONUTS page

[PMID:10588713-39] 39.0 ^39.1 Kioussi, C et al. (1999) Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc. Natl. Acad. Sci. U.S.A. 96 14378-82 PubMed GONUTS page

[PMID:9230312-40] 40.0 ^40.1 ^40.2 ^40.3 Ericson, J et al. (1997) Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell 90 169-80 PubMed GONUTS page

[PMID:9169845-41] 41.0 ^41.1 Mastick, GS et al. (1997) Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development 124 1985-97 PubMed GONUTS page

[PMID:11124115-42] 42.0 ^42.1 ^42.2 Yun, K et al. (2001) Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development 128 193-205 PubMed GONUTS page

[PMID:11050125-43] Stoykova, A et al. (2000) Pax6 modulates the dorsoventral patterning of the mammalian telencephalon. J. Neurosci. 20 8042-50 PubMed GONUTS page

[PMID:23431145-44] Elsen, GE et al. (2013) The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc. Natl. Acad. Sci. U.S.A. 110 4081-6 PubMed GONUTS page

[PMID:12764040-45] 45.0 ^45.1 Muzio, L & Mallamaci, A (2003) Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. Cereb. Cortex 13 641-7 PubMed GONUTS page

[PMID:18799682-46] Tucker, ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J. Neurosci. 28 9504-18 PubMed GONUTS page

[PMID:16919471-47] Li, H et al. (2006) Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol. Cell. Neurosci. 33 136-49 PubMed GONUTS page

[PMID:15917450-48] Kimura, J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J. Neurosci. 25 5097-108 PubMed GONUTS page

[PMID:12196586-49] 49.0 ^49.1 Bishop, KM et al. (2002) Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J. Neurosci. 22 7627-38 PubMed GONUTS page

[PMID:22031545-50] 50.0 ^50.1 ^50.2 ^50.3 Asami, M et al. (2011) The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex. Development 138 5067-78 PubMed GONUTS page

[PMID:11731698-51] Jaskoll, T et al. (2002) Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs (Print) 170 83-98 PubMed GONUTS page

[PMID:14586016-52] Andrews, GL & Mastick, GS (2003) R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J. Neurosci. 23 9873-80 PubMed GONUTS page

[PMID:11967891-53] Hevner, RF et al. (2002) Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J. Comp. Neurol. 447 8-17 PubMed GONUTS page

[PMID:18590716-54] Cho, A et al. (2008) FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism. Dev. Biol. 321 27-39 PubMed GONUTS page

[PMID:25100583-55] Gil-Sanz, C et al. (2014) Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J. Neurosci. 34 10475-87 PubMed GONUTS page

[PMID:24466353-56] Kim, BJ & Scott, DA (2014) Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. PLoS ONE 9 e87518 PubMed GONUTS page

[PMID:23434913-57] Itoh, Y et al. (2013) Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. Nat. Neurosci. 16 416-25 PubMed GONUTS page

[PMID:22764048-58] 58.0 ^58.1 Kredo-Russo, S et al. (2012) Pancreas-enriched miRNA refines endocrine cell differentiation. Development 139 3021-31 PubMed GONUTS page

[PMID:19409883-59] Okado, H et al. (2009) The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev. Biol. 331 140-51 PubMed GONUTS page

[PMID:16464444-60] Kim, J & Lauderdale, JD (2006) Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev. Biol. 292 486-505 PubMed GONUTS page

[PMID:14625556-61] Nishida, A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat. Neurosci. 6 1255-63 PubMed GONUTS page

[PMID:12050133-62] Zhu, CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development 129 2835-49 PubMed GONUTS page

[PMID:11209945-63] Wolf, LV et al. (2001) Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon. Neuroreport 12 329-33 PubMed GONUTS page

[PMID:23637604-64] Marakalala, MJ et al. (2013) Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1. PLoS Pathog. 9 e1003315 PubMed GONUTS page

[PMID:6877261-65] Favor, J (1983) A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea. Mutat. Res. 110 367-82 PubMed GONUTS page

[PMID:16497297-66] Sharp, P et al. (2006) Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function. Exp. Neurol. 198 511-8 PubMed GONUTS page

[PMID:21084637-67] Yan, Q et al. (2010) Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development. Proc. Natl. Acad. Sci. U.S.A. 107 21034-9 PubMed GONUTS page

[PMID:10197584-68] 68.0 ^68.1 ^68.2 Mansouri, A et al. (1999) Pax genes and their role in organogenesis. Cancer Res. 59 1707s-1709s; discussion 1709s-1710s PubMed GONUTS page

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