MOUSE:NRX1B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nrxn1
Protein Name(s)	Neurexin-1-beta Neurexin I-beta
External Links
UniProt	P0DI97
EMBL	CH466537
UniGene	Mm.491332
ProteinModelPortal	P0DI97
SMR	P0DI97
IntAct	P0DI97
PRIDE	P0DI97
Ensembl	ENSMUST00000172466
MGI	MGI:1096391
GeneTree	ENSGT00760000118991
TreeFam	TF334142
Reactome	REACT_196607
ChiTaRS	Nrxn1
PRO	PR:P0DI97
Proteomes	UP000000589
Bgee	P0DI97
ExpressionAtlas	P0DI97
GO	GO:0044295 GO:0030054 GO:0009986 GO:0030139 GO:0060076 GO:0060077 GO:0016021 GO:0005886 GO:0048306 GO:0050839 GO:0046872 GO:0097109 GO:0030534 GO:0001525 GO:0016339 GO:0021707 GO:0045184 GO:0097112 GO:0097116 GO:0097117 GO:0007157 GO:0097114 GO:0051490 GO:0097118 GO:0007158 GO:0042551 GO:0090004 GO:2000463 GO:0051968 GO:0097119 GO:0097104 GO:0097105 GO:0090126 GO:0035418 GO:0097120 GO:2000311 GO:2000310 GO:0035176 GO:0097091 GO:0042297 GO:0071625
Gene3D	2.60.120.200
InterPro	IPR013320 IPR001791 IPR029824 IPR003585 IPR027789
PANTHER	PTHR10127:SF565
Pfam	PF02210 PF01034
SMART	SM00294 SM00282
SUPFAM	SSF49899
PROSITE	PS50025

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046847	filopodium assembly	PMID:20869594^[1]	ECO:0000315			P		Figure 2A and D, soluble Nrxn1B interfere with filopodial density be increase rate in elimination of pre existing filopodia. Similar results seen in figure 2B and C. Figure 2E shows reduction in new filopodia stabilization when soluble Nrx1B is used, therefore showing that Nrxn1B and Nlgn1 interaction is needed for stabilization of dendrite filopodia. Similar results seen in figure 2I and J	complete CACAO 3141
	GO:0043498	cell surface binding	PMID:19450252^[2]	ECO:0000314			F		Figure 3B, C fusion protein B-NRX1-human bounds to surface of non-transfected and GFP-Nlgn1 transfected neurons.	complete
	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	PMID:20869594^[1]	ECO:0000315			P		Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC.	complete CACAO 3143
	GO:0097119	postsynaptic density protein 95 clustering	PMID:19450252^[2]	ECO:0000314			P		Further increase in PSD-95 clustering when B-NRX-Fc was applied to neurons, (75% increase), figure 4C.	complete
	GO:0097119	postsynaptic density protein 95 clustering	PMID:20869594^[1]	ECO:0000315			P		Figure 2K showed decrease in PSD-95 density when neurons treated with soluble Nrx1B-Fc. Therefore interaction between Nlgn1 and Nrxn1B is needed for location of PSD-95 at the postsynaptic membrane, figure 2P and Q.	complete
	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:20869594^[1]	ECO:0000315			P		Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC.	complete
	GO:2000463	positive regulation of excitatory postsynaptic membrane potential	PMID:20869594^[1]	ECO:0000315			P		Figure 2L-N, showed that using soluble Nrx1B-Fc treatment decrease frequency of AMPA receptor mediated mEPSC.	complete
involved_in	GO:0046847	filopodium assembly	PMID:20869594^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0014554)	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:19036990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1001571) part_of:(GO:0043025)	Seeded From UniProt	complete
involved_in	GO:0090126	protein-containing complex assembly involved in synapse maturation	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:20869594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097120	receptor localization to synapse	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097119	postsynaptic density protein 95 clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097117	guanylate kinase-associated protein clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097116	gephyrin clustering involved in postsynaptic density assembly	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097114	NMDA glutamate receptor clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097112	gamma-aminobutyric acid receptor clustering	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:19098102^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	PMID:12796785^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
involved_in	GO:0097105	presynaptic membrane assembly	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097104	postsynaptic membrane assembly	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097091	synaptic vesicle clustering	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060077	inhibitory synapse	PMID:12796785^[3]	ECO:0000305	curator inference used in manual assertion	GO:0097091	C		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0097091 GO:2000463	C		Seeded From UniProt	complete
involved_in	GO:0051968	positive regulation of synaptic transmission, glutamatergic	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051490	negative regulation of filopodium assembly	PMID:20869594^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:12796785^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	PMID:19098102^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99K10	F		Seeded From UniProt	complete
enables	GO:0048306	calcium-dependent protein binding	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042551	neuron maturation	PMID:15620359^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035418	protein localization to synapse	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
involved_in	GO:0021707	cerebellar granule cell differentiation	PMID:20537373^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61625 UniProtKB:Q9R171	P		Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19098102^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:20537373^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61625 UniProtKB:Q9R171	P		Seeded From UniProt	complete
involved_in	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:12796785^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q63373	C		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:21410790^[8]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:17360903^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:21410790^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	PMID:17360903^[9]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	PMID:12796785^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099560	synaptic membrane adhesion	PMID:12796785^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099542	trans-synaptic signaling by endocannabinoid	PMID:26213384^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0099542	trans-synaptic signaling by endocannabinoid	PMID:26213384^[10]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0099151	regulation of postsynaptic density assembly	PMID:21410790^[8]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099151	regulation of postsynaptic density assembly	PMID:21410790^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002037)	Seeded From UniProt	complete
involved_in	GO:0099150	regulation of postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099150	regulation of postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099150	regulation of postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099150	regulation of postsynaptic specialization assembly	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:17360903^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:17360903^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:17360903^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099059	integral component of presynaptic active zone membrane	PMID:17360903^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:27872870^[11]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:27872870^[11]	ECO:0006004	super-resolution microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:19036990^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:19036990^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:19036990^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	PMID:19036990^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21410790^[8]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17360903^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17360903^[9]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15620359^[6]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19036990^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17360903^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17360903^[9]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:21410790^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17360903^[9]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15620359^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19036990^[4]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0098693	regulation of synaptic vesicle cycle	PMID:19822762^[12]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19036990^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19822762^[12]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19036990^[4]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900020	positive regulation of protein kinase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099054	presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	P		Seeded From UniProt	complete
enables	GO:0097109	neuroligin family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090129	positive regulation of synapse maturation	PMID:19567877^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071625	vocalization behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071277	cellular response to calcium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	PMID:21356198^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88281 MGI:MGI:88282	P	regulates_o_occurs_in:(EMAPA:17544) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:12827191^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042297	vocal learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
colocalizes_with	GO:0036057	slit diaphragm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	PMID:19567877^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24613359^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N2Q7 UniProtKB:Q99JH7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010739	positive regulation of protein kinase A signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:12827191^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096362 MGI:MGI:1096389	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007269	neurotransmitter secretion	PMID:12827191^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096362 MGI:MGI:1096389	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:12827191^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096362 MGI:MGI:1096389	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007165	signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	PMID:12827191^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1096362 MGI:MGI:1096389	F		Seeded From UniProt	complete
enables	GO:0005105	type 1 fibroblast growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULB1	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628659	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037440	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007269	neurotransmitter secretion	PMID:9430716^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0222	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Chen, SX et al. (2010) Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron 67 967-83 PubMed GONUTS page
↑ ^2.0 ^2.1 Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Fairless, R et al. (2008) Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences. J. Neurosci. 28 12969-81 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Heine, M et al. (2008) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc. Natl. Acad. Sci. U.S.A. 105 20947-52 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page
↑ ^7.0 ^7.1 Uemura, T et al. (2010) Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141 1068-79 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Matsuda, K & Yuzaki, M (2011) Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur. J. Neurosci. 33 1447-61 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Taniguchi, H et al. (2007) Silencing of neuroligin function by postsynaptic neurexins. J. Neurosci. 27 2815-24 PubMed GONUTS page
↑ ^10.0 ^10.1 Anderson, GR et al. (2015) β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell 162 593-606 PubMed GONUTS page
↑ ^11.0 ^11.1 Chamma, I et al. (2016) Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy. Neurophotonics 3 041810 PubMed GONUTS page
↑ ^12.0 ^12.1 Etherton, MR et al. (2009) Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl. Acad. Sci. U.S.A. 106 17998-8003 PubMed GONUTS page
↑ ^13.0 ^13.1 Cheng, SB et al. (2009) Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J. Biol. Chem. 284 23251-9 PubMed GONUTS page
↑ Joo, JY et al. (2011) Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem. Biophys. Res. Commun. 406 627-32 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Missler, M et al. (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423 939-48 PubMed GONUTS page
↑ Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page
↑ Geppert, M et al. (1998) Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J. Biol. Chem. 273 1705-10 PubMed GONUTS page

[PMID:20869594-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Chen, SX et al. (2010) Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Neuron 67 967-83 PubMed GONUTS page

[PMID:19450252-2] 2.0 ^2.1 Barrow, SL et al. (2009) Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis. Neural Dev 4 17 PubMed GONUTS page

[PMID:12796785-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 ^3.13 ^3.14 ^3.15 Dean, C et al. (2003) Neurexin mediates the assembly of presynaptic terminals. Nat. Neurosci. 6 708-16 PubMed GONUTS page

[PMID:19036990-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Fairless, R et al. (2008) Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences. J. Neurosci. 28 12969-81 PubMed GONUTS page

[PMID:19098102-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 Heine, M et al. (2008) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc. Natl. Acad. Sci. U.S.A. 105 20947-52 PubMed GONUTS page

[PMID:15620359-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 ^6.12 ^6.13 ^6.14 ^6.15 ^6.16 Graf, ER et al. (2004) Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119 1013-26 PubMed GONUTS page

[PMID:20537373-7] 7.0 ^7.1 Uemura, T et al. (2010) Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell 141 1068-79 PubMed GONUTS page

[PMID:21410790-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Matsuda, K & Yuzaki, M (2011) Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur. J. Neurosci. 33 1447-61 PubMed GONUTS page

[PMID:17360903-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Taniguchi, H et al. (2007) Silencing of neuroligin function by postsynaptic neurexins. J. Neurosci. 27 2815-24 PubMed GONUTS page

[PMID:26213384-10] 10.0 ^10.1 Anderson, GR et al. (2015) β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell 162 593-606 PubMed GONUTS page

[PMID:27872870-11] 11.0 ^11.1 Chamma, I et al. (2016) Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy. Neurophotonics 3 041810 PubMed GONUTS page

[PMID:19822762-12] 12.0 ^12.1 Etherton, MR et al. (2009) Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc. Natl. Acad. Sci. U.S.A. 106 17998-8003 PubMed GONUTS page

[PMID:19567877-13] 13.0 ^13.1 Cheng, SB et al. (2009) Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J. Biol. Chem. 284 23251-9 PubMed GONUTS page

[PMID:21356198-14] Joo, JY et al. (2011) Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem. Biophys. Res. Commun. 406 627-32 PubMed GONUTS page

[PMID:12827191-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Missler, M et al. (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423 939-48 PubMed GONUTS page

[PMID:24613359-16] Um, JW et al. (2014) Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Rep 6 1096-109 PubMed GONUTS page

[PMID:9430716-17] Geppert, M et al. (1998) Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action. J. Biol. Chem. 273 1705-10 PubMed GONUTS page

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MOUSE:NRX1B

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