MOUSE:NMDE2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Grin2b
Protein Name(s)	Glutamate receptor ionotropic, NMDA 2B GluN2B Glutamate [NMDA] receptor subunit epsilon-2 N-methyl D-aspartate receptor subtype 2B NMDAR2B NR2B
External Links
UniProt	Q01097
EMBL	D10651 AK002963
CCDS	CCDS20648.1
PIR	I49704
RefSeq	NP_032197.3
UniGene	Mm.436649
ProteinModelPortal	Q01097
SMR	Q01097
BioGrid	200069
DIP	DIP-31568N
IntAct	Q01097
MINT	MINT-135847
ChEMBL	CHEMBL3442
GuidetoPHARMACOLOGY	457
PhosphoSite	Q01097
MaxQB	Q01097
PaxDb	Q01097
PRIDE	Q01097
GeneID	14812
KEGG	mmu:14812
CTD	2904
MGI	MGI:95821
eggNOG	NOG282132
HOGENOM	HOG000113802
HOVERGEN	HBG052635
InParanoid	Q01097
KO	K05210
PhylomeDB	Q01097
Reactome	REACT_257656
NextBio	287003
PRO	PR:Q01097
Proteomes	UP000000589
Genevestigator	Q01097
GO	GO:0030054 GO:0009986 GO:0016020 GO:0017146 GO:0043005 GO:0097481 GO:0014069 GO:0045211 GO:0042734 GO:0045202 GO:0008021 GO:0005262 GO:0005261 GO:0005234 GO:0004972 GO:0008270 GO:0001662 GO:0048266 GO:0070588 GO:0006816 GO:0098655 GO:0006812 GO:0050966 GO:0042596 GO:0001701 GO:0034220 GO:0035235 GO:0007612 GO:0007611 GO:0007613 GO:0060079 GO:0048168 GO:0060078 GO:0010738 GO:0048167 GO:0045471 GO:0007423 GO:0001964 GO:0001967 GO:0007268 GO:0035249
InterPro	IPR001828 IPR019594 IPR001508 IPR001320 IPR018884 IPR028082
Pfam	PF01094 PF00060 PF10565
PRINTS	PR00177
SMART	SM00918 SM00079
SUPFAM	SSF53822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315			C		Cell surface protein biotinylation and Western blotting was used, figure 3 A-C	complete CACAO 2398
	GO:0014069	postsynaptic density	PMID:21664258^[2]	ECO:0000315			C		Figure 3A and C, Western blot showed levels of both NR2B subunits were significantly decreased in the PSD (postsynaptic density) fraction of heterozygous reeler mice.	complete
part_of	GO:0098794	postsynapse	PMID:21144999^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0005377)	Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00960	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00960	F		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00960	P		Seeded From UniProt	complete
enables	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	PMID:19726645^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(GO:0060076) occurs_in:(CL:0002608) occurs_in:(UBERON:0003883)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:19726645^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0043197) part_of:(CL:0002608) part_of:(UBERON:0014556)	Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13224	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13224	F		Seeded From UniProt	complete
involved_in	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13224	P		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925,UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:22820466^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04925,UniProtKB:P39688	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:26609151^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:26609151^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608) part_of:(GO:0045202)	Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	PMID:26609151^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0009986)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21664258^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21795692^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002608)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17229826^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:16157280^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00960	F		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	PMID:19726645^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19726645^[4]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098839	postsynaptic density membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 PANTHER:PTN000751216	C		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 PANTHER:PTN000751216	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 MGI:MGI:95823 PANTHER:PTN000751216 RGD:2737	P		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 PANTHER:PTN000751216 RGD:2737 RGD:2738 RGD:2739 RGD:2740 UniProtKB:O15399 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q14957	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004620 FB:FBgn0052704 MGI:MGI:95808 MGI:MGI:95813 MGI:MGI:95816 PANTHER:PTN000437926 RGD:621531 TAIR:locus:2207165 UniProtKB:Q12879 UniProtKB:Q13224 UniProtKB:Q16478 WB:WBGene00001612	C		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95820 MGI:MGI:95821 MGI:MGI:95822 MGI:MGI:95823 PANTHER:PTN000751216 RGD:2737 RGD:2738 RGD:2739 RGD:2740 UniProtKB:O15399 UniProtKB:Q13224 UniProtKB:Q14957	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
enables	GO:1904315	transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:16901514^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
part_of	GO:0099061	integral component of postsynaptic density membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098989	NMDA selective glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0098688	parallel fiber to Purkinje cell synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0098686	hippocampal mossy fiber to CA3 synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097553	calcium ion transmembrane import into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	P		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:20661302^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:14645471^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:9147327^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P	occurs_in:(EMAPA:32770) regulates_o_occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:16157280^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:16045501^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:12832518^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:11530236^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:10634899^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060078	regulation of postsynaptic membrane potential	PMID:16157280^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	PMID:16190898^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050839	cell adhesion molecule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048511	rhythmic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048266	behavioral response to pain	PMID:11711849^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:16710293^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3701351	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:11719203^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046960	sensitization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	PMID:11530236^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12890763^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	PMID:12676993^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:16710293^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:14645471^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043408	regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043113	receptor clustering	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
part_of	GO:0043083	synaptic cleft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:26627310^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042596	fear response	PMID:16157280^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042165	neurotransmitter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0035255	ionotropic glutamate receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035235	ionotropic glutamate receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
enables	GO:0031749	D2 dopamine receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
enables	GO:0022849	glutamate-gated calcium ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	F		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:9003035^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35438	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
enables	GO:0016595	glutamate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0016594	glycine binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9003035^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8840015^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10846156^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:24069373^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21880917^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:17114649^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:16190898^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:15748150^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014049	positive regulation of glutamate secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010738	regulation of protein kinase A signaling	PMID:24336715^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010243	response to organonitrogen compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:21880917^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000598) part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008306	associative learning	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:20418887^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549)	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:10846156^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:24336715^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:16157280^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:10485705^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:16710293^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3701351	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:10485705^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007423	sensory organ development	PMID:8789948^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:8789948^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:16045501^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12816890^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	PMID:7531804^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12816890^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:7531804^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0005234	extracellularly glutamate-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0005149	interleukin-1 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:7531804^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:1377365^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95819	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12832518^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95823	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:9458051^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928293	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12832518^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:12816890^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	PMID:10634899^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13224	F		Seeded From UniProt	complete
enables	GO:0004972	NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:8789948^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:16221859^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95820	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:11488959^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9147327^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928295	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:16710293^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3701351	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001508	action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2738	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
involved_in	GO:0019722	calcium-mediated signaling	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0022849	P		Seeded From UniProt	complete
enables	GO:0004970	ionotropic glutamate receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR019594	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001320 InterPro:IPR001508 InterPro:IPR019594	C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001508	F		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	PMID:14622581^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:14622581^[42]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-3928635 Reactome:R-MMU-3928613	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0120038	plasma membrane bounded cell projection part	PMID:26627310^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0017146	NMDA selective glutamate receptor complex	PMID:26627310^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page
↑ ^2.0 ^2.1 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page
↑ Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Akashi, K et al. (2009) NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 10869-82 PubMed GONUTS page
↑ ^5.0 ^5.1 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page
↑ Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhao, MG et al. (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47 859-72 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Berberich, S et al. (2007) The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology 52 77-86 PubMed GONUTS page
↑ Jin, SX & Feig, LA (2010) Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS ONE 5 e11732 PubMed GONUTS page
↑ ^12.0 ^12.1 Köhr, G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 10791-9 PubMed GONUTS page
↑ ^13.0 ^13.1 Ito, I et al. (1997) Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit. J. Physiol. (Lond.) 500 ( Pt 2) 401-8 PubMed GONUTS page
↑ ^14.0 ^14.1 Toyoda, H et al. (2005) Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur. J. Neurosci. 22 485-94 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Brickley, SG et al. (2003) NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. J. Neurosci. 23 4958-66 PubMed GONUTS page
↑ ^16.0 ^16.1 Gordey, M et al. (2001) Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience 105 987-97 PubMed GONUTS page
↑ ^17.0 ^17.1 Tovar, KR et al. (2000) Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit. J. Neurophysiol. 83 616-20 PubMed GONUTS page
↑ ^18.0 ^18.1 Abe, T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22 1445-54 PubMed GONUTS page
↑ Wainai, T et al. (2001) Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. Neuroreport 12 3169-72 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page
↑ Lu, HC et al. (2001) Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Neuron 32 619-34 PubMed GONUTS page
↑ Tao, YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Neurosci. 23 6703-12 PubMed GONUTS page
↑ Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page
↑ ^25.0 ^25.1 Chazot, PL & Stephenson, FA (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J. Neurochem. 68 507-16 PubMed GONUTS page
↑ Snell, LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. Brain Res. 40 71-8 PubMed GONUTS page
↑ ^27.0 ^27.1 Setou, M et al. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288 1796-802 PubMed GONUTS page
↑ Breiderhoff, T et al. (2013) Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE 8 e75006 PubMed GONUTS page
↑ ^29.0 ^29.1 Kiraly, DD et al. (2011) Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. J. Neurosci. 31 12554-65 PubMed GONUTS page
↑ Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page
↑ Trinidad, JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J. Neurochem. 92 1306-16 PubMed GONUTS page
↑ ^32.0 ^32.1 Corcoran, KA et al. (2013) Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex. J. Neurosci. 33 19492-8 PubMed GONUTS page
↑ Shmelkov, SV et al. (2010) Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat. Med. 16 598-602, 1p following 602 PubMed GONUTS page
↑ ^34.0 ^34.1 Tang, YP et al. (1999) Genetic enhancement of learning and memory in mice. Nature 401 63-9 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Kutsuwada, T et al. (1996) Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron 16 333-44 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Okada, H et al. (2003) NMDA receptors in cortical development are essential for the generation of coordinated increases in [Ca2+](i) in "neuronal domains". Cereb. Cortex 13 749-57 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 Tsuzuki, K et al. (1994) Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA receptor channel. Brain Res. Mol. Brain Res. 26 37-46 PubMed GONUTS page
↑ Kutsuwada, T et al. (1992) Molecular diversity of the NMDA receptor channel. Nature 358 36-41 PubMed GONUTS page
↑ Sprengel, R et al. (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92 279-89 PubMed GONUTS page
↑ Van de Ven, TJ et al. (2005) The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. J. Neurosci. 25 9488-96 PubMed GONUTS page
↑ Takeuchi, T et al. (2001) Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur. J. Neurosci. 14 153-60 PubMed GONUTS page
↑ ^42.0 ^42.1 Krapivinsky, G et al. (2003) The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40 775-84 PubMed GONUTS page

[PMID:17229826-1] 1.0 ^1.1 ^1.2 Qiu, S & Weeber, EJ (2007) Reelin signaling facilitates maturation of CA1 glutamatergic synapses. J. Neurophysiol. 97 2312-21 PubMed GONUTS page

[PMID:21664258-2] 2.0 ^2.1 Ventruti, A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189 32-42 PubMed GONUTS page

[PMID:21144999-3] Dani, A et al. (2010) Superresolution imaging of chemical synapses in the brain. Neuron 68 843-56 PubMed GONUTS page

[PMID:19726645-4] 4.0 ^4.1 ^4.2 ^4.3 Akashi, K et al. (2009) NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses. J. Neurosci. 29 10869-82 PubMed GONUTS page

[PMID:22820466-5] 5.0 ^5.1 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page

[PMID:26609151-6] 6.0 ^6.1 ^6.2 Takei, Y et al. (2015) Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J. Neurosci. 35 15539-54 PubMed GONUTS page

[PMID:21795692-7] Verpelli, C et al. (2011) Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses. J. Biol. Chem. 286 34839-50 PubMed GONUTS page

[PMID:16157280-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Zhao, MG et al. (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47 859-72 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16901514-10] Berberich, S et al. (2007) The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology 52 77-86 PubMed GONUTS page

[PMID:20661302-11] Jin, SX & Feig, LA (2010) Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS ONE 5 e11732 PubMed GONUTS page

[PMID:14645471-12] 12.0 ^12.1 Köhr, G et al. (2003) Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J. Neurosci. 23 10791-9 PubMed GONUTS page

[PMID:9147327-13] 13.0 ^13.1 Ito, I et al. (1997) Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit. J. Physiol. (Lond.) 500 ( Pt 2) 401-8 PubMed GONUTS page

[PMID:16045501-14] 14.0 ^14.1 Toyoda, H et al. (2005) Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur. J. Neurosci. 22 485-94 PubMed GONUTS page

[PMID:12832518-15] 15.0 ^15.1 ^15.2 Brickley, SG et al. (2003) NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. J. Neurosci. 23 4958-66 PubMed GONUTS page

[PMID:11530236-16] 16.0 ^16.1 Gordey, M et al. (2001) Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience 105 987-97 PubMed GONUTS page

[PMID:10634899-17] 17.0 ^17.1 Tovar, KR et al. (2000) Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit. J. Neurophysiol. 83 616-20 PubMed GONUTS page

[PMID:16190898-18] 18.0 ^18.1 Abe, T et al. (2005) Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain. Eur. J. Neurosci. 22 1445-54 PubMed GONUTS page

[PMID:11711849-19] Wainai, T et al. (2001) Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit. Neuroreport 12 3169-72 PubMed GONUTS page

[PMID:16710293-20] 20.0 ^20.1 ^20.2 ^20.3 Nakazawa, T et al. (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 25 2867-77 PubMed GONUTS page

[PMID:11719203-21] Lu, HC et al. (2001) Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Neuron 32 619-34 PubMed GONUTS page

[PMID:12890763-22] Tao, YX et al. (2003) Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J. Neurosci. 23 6703-12 PubMed GONUTS page

[PMID:12676993-23] Fukaya, M et al. (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100 4855-60 PubMed GONUTS page

[PMID:26627310-24] 24.0 ^24.1 ^24.2 Berg, JM et al. (2015) JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron 88 1173-1191 PubMed GONUTS page

[PMID:9003035-25] 25.0 ^25.1 Chazot, PL & Stephenson, FA (1997) Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. J. Neurochem. 68 507-16 PubMed GONUTS page

[PMID:8840015-26] Snell, LD et al. (1996) Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Brain Res. Mol. Brain Res. 40 71-8 PubMed GONUTS page

[PMID:10846156-27] 27.0 ^27.1 Setou, M et al. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288 1796-802 PubMed GONUTS page

[PMID:24069373-28] Breiderhoff, T et al. (2013) Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE 8 e75006 PubMed GONUTS page

[PMID:21880917-29] 29.0 ^29.1 Kiraly, DD et al. (2011) Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. J. Neurosci. 31 12554-65 PubMed GONUTS page

[PMID:17114649-30] Munton, RP et al. (2007) Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol. Cell Proteomics 6 283-93 PubMed GONUTS page

[PMID:15748150-31] Trinidad, JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J. Neurochem. 92 1306-16 PubMed GONUTS page

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MOUSE:NMDE2

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