MOUSE:MSH2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Msh2
Protein Name(s)	DNA mismatch repair protein Msh2 MutS protein homolog 2
External Links
UniProt	P43247
EMBL	X81143 U21011 BC047117
CCDS	CCDS29019.1
PIR	S53608
RefSeq	NP_032654.1
UniGene	Mm.4619
ProteinModelPortal	P43247
SMR	P43247
BioGrid	201525
DIP	DIP-57027N
IntAct	P43247
STRING	10090.ENSMUSP00000024967
iPTMnet	P43247
PhosphoSite	P43247
EPD	P43247
PaxDb	P43247
PRIDE	P43247
Ensembl	ENSMUST00000024967
GeneID	17685
KEGG	mmu:17685
UCSC	uc008dva.1
CTD	4436
MGI	MGI:101816
eggNOG	KOG0219 COG0249
HOGENOM	HOG000196498
HOVERGEN	HBG006399
InParanoid	P43247
KO	K08735
OMA	NDWYLAY
OrthoDB	EOG76DTRW
PhylomeDB	P43247
TreeFam	TF351780
Reactome	R-MMU-5358565 R-MMU-5358606
NextBio	292252
PRO	PR:P43247
Proteomes	UP000000589
Bgee	P43247
CleanEx	MM_MSH2
ExpressionAtlas	P43247
Genevisible	P43247
GO	GO:0016020 GO:0032301 GO:0032302 GO:0000784 GO:0005634 GO:0043531 GO:0005524 GO:0016887 GO:0019237 GO:0003684 GO:0032181 GO:0003677 GO:0000406 GO:0019899 GO:0000400 GO:0032137 GO:0000404 GO:0000287 GO:0030983 GO:0032357 GO:0008022 GO:0042803 GO:0019901 GO:0032138 GO:0032142 GO:0032143 GO:0003697 GO:0000403 GO:0030183 GO:0019724 GO:0007050 GO:0006974 GO:0008340 GO:0006281 GO:0006302 GO:0007281 GO:0001701 GO:0031573 GO:0008630 GO:0042771 GO:0045190 GO:0043570 GO:0008584 GO:0006311 GO:0006298 GO:0045910 GO:0043524 GO:0045128 GO:0006119 GO:0051096 GO:0006301 GO:0010224 GO:0010165 GO:0016446 GO:0016447 GO:0002204
Gene3D	3.30.420.110 3.40.50.300
InterPro	IPR011184 IPR007695 IPR000432 IPR007861 IPR007696 IPR007860 IPR032642 IPR027417
PANTHER	PTHR11361:SF35
Pfam	PF01624 PF05188 PF05192 PF05190 PF00488
PIRSF	PIRSF005813
SMART	SM00534 SM00533
SUPFAM	SSF48334 SSF52540 SSF53150
PROSITE	PS00486

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0048298	positive regulation of isotype switching to IgA isotypes	PMID:10430621^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002106) occurs_in:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:10430621^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002106) occurs_in:(CL:0000236)	Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 TAIR:locus:2095097 UniProtKB:P43246	P		Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015546 PANTHER:PTN000145640 PomBase:SPBC19G7.01c UniProtKB:P43246 WB:WBGene00003418 ZFIN:ZDB-GENE-040426-2932	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643 WB:WBGene00003418	P		Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779	C		Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:1343961 PANTHER:PTN002260779 SGD:S000001162 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002260779 SGD:S000001162	F		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145643	P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 UniProtKB:P43246	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 FB:FBgn0015546 MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN000145505 PomBase:SPBC19G7.01c PomBase:SPCC285.16c SGD:S000000688 SGD:S000001162 SGD:S000002504 SGD:S000005450 TAIR:locus:2095097 UniProtKB:P20585 UniProtKB:P43246 UniProtKB:P52701 WB:WBGene00003418 WB:WBGene00003422	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 PANTHER:PTN000145640 RGD:620786 SGD:S000005450 UniProtKB:P43246	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450 UniProtKB:P43246 UniProtKB:P52701	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10625 PANTHER:PTN002260779 SGD:S000002504 SGD:S000005450	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101816 MGI:MGI:109519 MGI:MGI:1343961 PANTHER:PTN002260779 TAIR:locus:2095097 TAIR:locus:2131829 UniProtKB:O04716	F		Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000145640 UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071168	protein localization to chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051096	positive regulation of helicase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045910	negative regulation of DNA recombination	PMID:7628020^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045910	negative regulation of DNA recombination	PMID:10545954^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045910	negative regulation of DNA recombination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045190	isotype switching	PMID:12743174^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045190	isotype switching	PMID:10430621^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2151801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043570	maintenance of DNA repeat elements	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
contributes_to	GO:0043531	ADP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:16805809^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P	occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:10097137^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P	occurs_in:(EMAPA:35465)	Seeded From UniProt	complete
contributes_to	GO:0032405	MutLalpha complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0032357	oxidized purine DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	PMID:16713580^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	C		Seeded From UniProt	complete
contributes_to	GO:0032181	dinucleotide repeat insertion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0032143	single thymine insertion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0032142	single guanine insertion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0032139	dinucleotide insertion or deletion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	PMID:16713580^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	PMID:16713580^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0032137	guanine/thymine mispair binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031573	intra-S DNA damage checkpoint	PMID:15533840^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103557	P	occurs_in:(EMAPA:17528) occurs_in:(CL:0000312)	Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	PMID:7550317^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	F		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	PMID:14744764^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	F		Seeded From UniProt	complete
contributes_to	GO:0030983	mismatched DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030183	B cell differentiation	PMID:9697843^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019724	B cell mediated immunity	PMID:9927509^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019724	B cell mediated immunity	PMID:9697843^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
enables	GO:0019237	centromeric DNA binding	PMID:16260499^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17972) occurs_in:(CL:0000017)	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:14568978^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	F		Seeded From UniProt	complete
contributes_to	GO:0016887	ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:15494304^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109352	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:15955838^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:14568978^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:14563316^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016447	somatic recombination of immunoglobulin gene segments	PMID:11828012^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2151801	P	occurs_in:(EMAPA:18767) occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:15494304^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109352	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:9697843^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:9697842^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:9607916^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:14568978^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0016446	somatic hypermutation of immunoglobulin genes	PMID:9607915^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010224	response to UV-B	PMID:15166087^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010165	response to X-ray	PMID:12687013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:14744764^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	P	occurs_in:(EMAPA:35465)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:10097137^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P	occurs_in:(EMAPA:35465)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:17912366^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P	results_in_development_of:(EMAPA:31476)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008340	determination of adult lifespan	PMID:10545954^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:17912366^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P	occurs_in:(EMAPA:17972) results_in_development_of:(CL:0000015)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	PMID:12687013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:14744764^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:11429706^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:10720738^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:10097137^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006302	double-strand break repair	PMID:17912366^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P	occurs_in:(CL:0000017)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006301	postreplication repair	PMID:7628020^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006301	postreplication repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:16728433^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109519	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9697842^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9288110^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:8706033^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:7628020^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:23071719^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:17331550^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:16728433^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:14744764^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:12531017^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389314	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:11890935^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:11046134^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10992298^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2151801	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10874005^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:10581038^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9244348^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:9157971^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:23603115^[41]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	PMID:11555625^[42]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006298	mismatch repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	PMID:12687013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006281	DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006119	oxidative phosphorylation	PMID:16805809^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857940	P	occurs_in:(EMAPA:32845)\|occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9443401^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14744764^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7628020^[3]	ECO:0000305	curator inference used in manual assertion	GO:0003684 GO:0006298 GO:0006301	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620786	C		Seeded From UniProt	complete
contributes_to	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0003697	single-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0003690	double-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:7628020^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	F		Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:10545954^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:10545954^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858055	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002204	somatic recombination of immunoglobulin genes involved in immune response	PMID:12743174^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101938	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9288110^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9425892^[44]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P		Seeded From UniProt	complete
contributes_to	GO:0000400	four-way junction DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
contributes_to	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43246	F		Seeded From UniProt	complete
involved_in	GO:0071168	protein localization to chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
involved_in	GO:0051096	positive regulation of helicase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
involved_in	GO:0045910	negative regulation of DNA recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
involved_in	GO:0043570	maintenance of DNA repeat elements	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032405	MutLalpha complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032357	oxidized purine DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
part_of	GO:0032302	MutSbeta complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	C		Seeded From UniProt	complete
part_of	GO:0032301	MutSalpha complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	C		Seeded From UniProt	complete
enables	GO:0032181	dinucleotide repeat insertion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032143	single thymine insertion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032142	single guanine insertion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032139	dinucleotide insertion or deletion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0032137	guanine/thymine mispair binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P43246 ensembl:ENSP00000233146	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	F		Seeded From UniProt	complete
involved_in	GO:0006298	mismatch repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR032642 InterPro:IPR036678	P		Seeded From UniProt	complete
enables	GO:0030983	mismatched DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000432 InterPro:IPR007695 InterPro:IPR007696 InterPro:IPR007860 InterPro:IPR007861 InterPro:IPR011184 InterPro:IPR016151 InterPro:IPR036678	F		Seeded From UniProt	complete
part_of	GO:0032300	mismatch repair complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032642	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Schrader, CE et al. (1999) Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190 323-30 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 de Wind, N et al. (1995) Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82 321-30 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 de Wind, N et al. (1999) HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat. Genet. 23 359-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Schrader, CE et al. (2003) Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197 1377-83 PubMed GONUTS page
↑ ^6.0 ^6.1 Francisconi, S et al. (2006) Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair. J. Neurochem. 98 223-33 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Toft, NJ et al. (1999) Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. Proc. Natl. Acad. Sci. U.S.A. 96 3911-5 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page
↑ van Oosten, M et al. (2005) Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes. DNA Repair (Amst.) 4 81-9 PubMed GONUTS page
↑ Reitmair, AH et al. (1995) MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat. Genet. 11 64-70 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Lin, DP et al. (2004) An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res. 64 517-22 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Rada, C et al. (1998) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9 135-41 PubMed GONUTS page
↑ Vora, KA et al. (1999) Severe attenuation of the B cell immune response in Msh2-deficient mice. J. Exp. Med. 189 471-82 PubMed GONUTS page
↑ Kolas, NK et al. (2005) Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J. Cell Biol. 171 447-58 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Martin, A et al. (2003) Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J. Exp. Med. 198 1171-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Rada, C et al. (2004) Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16 163-71 PubMed GONUTS page
↑ Min, IM et al. (2005) Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J. Exp. Med. 201 1885-90 PubMed GONUTS page
↑ Min, IM et al. (2003) The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2. Immunity 19 515-24 PubMed GONUTS page
↑ Schrader, CE et al. (2002) Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195 367-73 PubMed GONUTS page
↑ ^20.0 ^20.1 Frey, S et al. (1998) Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9 127-34 PubMed GONUTS page
↑ Phung, QH et al. (1998) Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187 1745-51 PubMed GONUTS page
↑ Jacobs, H et al. (1998) Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J. Exp. Med. 187 1735-43 PubMed GONUTS page
↑ Young, LC et al. (2004) DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study. Carcinogenesis 25 1821-7 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Franchitto, A et al. (2003) The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 22 2110-20 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Paul, C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2 e989 PubMed GONUTS page
↑ Sansom, OJ et al. (2001) Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 3580-4 PubMed GONUTS page
↑ Jansen, L et al. (2000) Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents. Toxicol. Lett. 112-113 245-50 PubMed GONUTS page
↑ ^28.0 ^28.1 Hegan, DC et al. (2006) Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 27 2402-8 PubMed GONUTS page
↑ ^29.0 ^29.1 Cranston, A et al. (1997) Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat. Genet. 17 114-8 PubMed GONUTS page
↑ Reitmair, AH et al. (1996) Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res. 56 3842-9 PubMed GONUTS page
↑ Bourn, RL et al. (2012) Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues. PLoS ONE 7 e47085 PubMed GONUTS page
↑ Burr, KL et al. (2007) The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat. Res. 617 147-51 PubMed GONUTS page
↑ Egashira, A et al. (2002) Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. DNA Repair (Amst.) 1 881-93 PubMed GONUTS page
↑ Zhang, S et al. (2002) Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum. Mutat. Res. 500 67-74 PubMed GONUTS page
↑ Jenab-Wolcott, J et al. (2000) The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Mol. Cell. Biol. 20 8373-81 PubMed GONUTS page
↑ Smits, R et al. (2000) Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer 29 229-39 PubMed GONUTS page
↑ Andrew, SE et al. (2000) Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 21 1291-5 PubMed GONUTS page
↑ Manley, K et al. (1999) Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat. Genet. 23 471-3 PubMed GONUTS page
↑ Andrew, SE et al. (1997) Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. Oncogene 15 123-9 PubMed GONUTS page
↑ Fink, D et al. (1997) In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res. 57 1841-5 PubMed GONUTS page
↑ Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page
↑ Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page
↑ de Wind, N et al. (1998) Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res. 58 248-55 PubMed GONUTS page
↑ Toft, NJ et al. (1998) No female embryonic lethality in mice nullizygous for Msh2 and p53. Nat. Genet. 18 17 PubMed GONUTS page

[PMID:10430621-1] 1.0 ^1.1 ^1.2 Schrader, CE et al. (1999) Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. J. Exp. Med. 190 323-30 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7628020-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 de Wind, N et al. (1995) Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 82 321-30 PubMed GONUTS page

[PMID:10545954-4] 4.0 ^4.1 ^4.2 ^4.3 de Wind, N et al. (1999) HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat. Genet. 23 359-62 PubMed GONUTS page

[PMID:12743174-5] 5.0 ^5.1 Schrader, CE et al. (2003) Mlh1 can function in antibody class switch recombination independently of Msh2. J. Exp. Med. 197 1377-83 PubMed GONUTS page

[PMID:16805809-6] 6.0 ^6.1 Francisconi, S et al. (2006) Mitochondrial dysfunction and increased sensitivity to excitotoxicity in mice deficient in DNA mismatch repair. J. Neurochem. 98 223-33 PubMed GONUTS page

[PMID:10097137-7] 7.0 ^7.1 ^7.2 Toft, NJ et al. (1999) Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. Proc. Natl. Acad. Sci. U.S.A. 96 3911-5 PubMed GONUTS page

[PMID:16713580-8] 8.0 ^8.1 ^8.2 Yoshioka, K et al. (2006) ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol. Cell 22 501-10 PubMed GONUTS page

[PMID:15533840-9] van Oosten, M et al. (2005) Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes. DNA Repair (Amst.) 4 81-9 PubMed GONUTS page

[PMID:7550317-10] Reitmair, AH et al. (1995) MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat. Genet. 11 64-70 PubMed GONUTS page

[PMID:14744764-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Lin, DP et al. (2004) An Msh2 point mutation uncouples DNA mismatch repair and apoptosis. Cancer Res. 64 517-22 PubMed GONUTS page

[PMID:9697843-12] 12.0 ^12.1 ^12.2 Rada, C et al. (1998) Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 9 135-41 PubMed GONUTS page

[PMID:9927509-13] Vora, KA et al. (1999) Severe attenuation of the B cell immune response in Msh2-deficient mice. J. Exp. Med. 189 471-82 PubMed GONUTS page

[PMID:16260499-14] Kolas, NK et al. (2005) Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J. Cell Biol. 171 447-58 PubMed GONUTS page

[PMID:14568978-15] 15.0 ^15.1 ^15.2 Martin, A et al. (2003) Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination. J. Exp. Med. 198 1171-8 PubMed GONUTS page

[PMID:15494304-16] 16.0 ^16.1 Rada, C et al. (2004) Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 16 163-71 PubMed GONUTS page

[PMID:15955838-17] Min, IM et al. (2005) Shifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2. J. Exp. Med. 201 1885-90 PubMed GONUTS page

[PMID:14563316-18] Min, IM et al. (2003) The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2. Immunity 19 515-24 PubMed GONUTS page

[PMID:11828012-19] Schrader, CE et al. (2002) Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions. J. Exp. Med. 195 367-73 PubMed GONUTS page

[PMID:9697842-20] 20.0 ^20.1 Frey, S et al. (1998) Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. Immunity 9 127-34 PubMed GONUTS page

[PMID:9607916-21] Phung, QH et al. (1998) Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein. J. Exp. Med. 187 1745-51 PubMed GONUTS page

[PMID:9607915-22] Jacobs, H et al. (1998) Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J. Exp. Med. 187 1735-43 PubMed GONUTS page

[PMID:15166087-23] Young, LC et al. (2004) DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study. Carcinogenesis 25 1821-7 PubMed GONUTS page

[PMID:12687013-24] 24.0 ^24.1 ^24.2 Franchitto, A et al. (2003) The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 22 2110-20 PubMed GONUTS page

[PMID:17912366-25] 25.0 ^25.1 ^25.2 Paul, C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE 2 e989 PubMed GONUTS page

[PMID:11429706-26] Sansom, OJ et al. (2001) Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20 3580-4 PubMed GONUTS page

[PMID:10720738-27] Jansen, L et al. (2000) Acceleration of lymphomagenesis in mismatch-repair deficient mice by exposure to genotoxic agents. Toxicol. Lett. 112-113 245-50 PubMed GONUTS page

[PMID:16728433-28] 28.0 ^28.1 Hegan, DC et al. (2006) Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis 27 2402-8 PubMed GONUTS page

[PMID:9288110-29] 29.0 ^29.1 Cranston, A et al. (1997) Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat. Genet. 17 114-8 PubMed GONUTS page

[PMID:8706033-30] Reitmair, AH et al. (1996) Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res. 56 3842-9 PubMed GONUTS page

[PMID:23071719-31] Bourn, RL et al. (2012) Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues. PLoS ONE 7 e47085 PubMed GONUTS page

[PMID:17331550-32] Burr, KL et al. (2007) The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat. Res. 617 147-51 PubMed GONUTS page

[PMID:12531017-33] Egashira, A et al. (2002) Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. DNA Repair (Amst.) 1 881-93 PubMed GONUTS page

[PMID:11890935-34] Zhang, S et al. (2002) Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum. Mutat. Res. 500 67-74 PubMed GONUTS page

[PMID:11046134-35] Jenab-Wolcott, J et al. (2000) The absence of Msh2 alters abelson virus pre-B-cell transformation by influencing p53 mutation. Mol. Cell. Biol. 20 8373-81 PubMed GONUTS page

[PMID:10992298-36] Smits, R et al. (2000) Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer 29 229-39 PubMed GONUTS page

[PMID:10874005-37] Andrew, SE et al. (2000) Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis 21 1291-5 PubMed GONUTS page

[PMID:10581038-38] Manley, K et al. (1999) Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat. Genet. 23 471-3 PubMed GONUTS page

[PMID:9244348-39] Andrew, SE et al. (1997) Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice. Oncogene 15 123-9 PubMed GONUTS page

[PMID:9157971-40] Fink, D et al. (1997) In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res. 57 1841-5 PubMed GONUTS page

[PMID:23603115-41] Ghodgaonkar, MM et al. (2013) Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol. Cell 50 323-32 PubMed GONUTS page

[PMID:11555625-42] Ellison, AR et al. (2001) Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiae. Hum. Mol. Genet. 10 1889-900 PubMed GONUTS page

[PMID:9443401-43] Wind, N et al. (1998) Mouse models for hereditary nonpolyposis colorectal cancer. Cancer Res. 58 248-55 PubMed GONUTS page

[PMID:9425892-44] Toft, NJ et al. (1998) No female embryonic lethality in mice nullizygous for Msh2 and p53. Nat. Genet. 18 17 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

MOUSE:MSH2

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

i

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools