GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8706033
| Citation |
Reitmair, AH, Redston, M, Cai, JC, Chuang, TC, Bjerknes, M, Cheng, H, Hay, K, Gallinger, S, Bapat, B and Mak, TW (1996) Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res. 56:3842-9 |
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| Abstract |
Hereditary nonpolyposis colorectal cancer is associated with defects in DNA mismatch repair. Here, we characterize tumor susceptibility of the recently described Msh2-deficient mouse model. Within the first year of observation, all homozygous mice succumbed to disease, with lymphomas observed in at least 80% of the cases. The majority (70%) of animals 6 months or older developed intestinal neoplasms associated with APC inactivation. Microsatellite instability was more common in carcinomas than in adenomas, but uncommon in normal tissues. Some animals (7%) developed a variety of skin neoplasms analogous to the Muir-Torre syndrome. Msh2-/- mice implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans. |
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| Keywords |
Adenomatous Polyposis Coli Protein; Animals; Base Sequence; Cytoskeletal Proteins/analysis; DNA Repair; DNA-Binding Proteins/analysis; DNA-Binding Proteins/genetics; Female; Fungal Proteins; Intestinal Neoplasms/etiology; Male; Mice; Mice, Inbred C57BL; Microsatellite Repeats; Molecular Sequence Data; MutS Homolog 2 Protein; Skin Neoplasms/etiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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