MOUSE:MK14

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mapk14 (synonyms: Crk1, Csbp1, Csbp2)
Protein Name(s)	Mitogen-activated protein kinase 14 MAP kinase 14 MAPK 14 CRK1 Mitogen-activated protein kinase p38 alpha MAP kinase p38 alpha
External Links
UniProt	P47811
EMBL	U10871 D83073 AF128892 AK151348 AK153025 AK089059 AK133684 CT009661 CT009661 BC012235 AF195850 X65067
CCDS	CCDS28583.1 CCDS50048.1
PIR	I49066
RefSeq	NP_001161980.1 NP_001161985.1 NP_001161986.1 NP_036081.1
UniGene	Mm.311337
PDB	1LEW 1LEZ 1P38 1YW2 1YWR 2EWA 2GHL 2GHM 2GTM 2GTN 2OZA 2PUU 3P4K 3P5K 3P78 3P79 3P7A 3P7B 3P7C 3PY3 3TG1 4KA3 4LOO 4LOP 4LOQ
PDBsum	1LEW 1LEZ 1P38 1YW2 1YWR 2EWA 2GHL 2GHM 2GTM 2GTN 2OZA 2PUU 3P4K 3P5K 3P78 3P79 3P7A 3P7B 3P7C 3PY3 3TG1 4KA3 4LOO 4LOP 4LOQ
ProteinModelPortal	P47811
SMR	P47811
BioGrid	204969
DIP	DIP-31073N
IntAct	P47811
MINT	MINT-1204448
STRING	10090.ENSMUSP00000004990
BindingDB	P47811
ChEMBL	CHEMBL2336
PhosphoSite	P47811
MaxQB	P47811
PaxDb	P47811
PRIDE	P47811
Ensembl	ENSMUST00000004990 ENSMUST00000062694 ENSMUST00000114752 ENSMUST00000114754
GeneID	26416
KEGG	mmu:26416
UCSC	uc008brl.2
CTD	1432
MGI	MGI:1346865
eggNOG	COG0515
GeneTree	ENSGT00550000074271
HOVERGEN	HBG014652
InParanoid	P47811
KO	K04441
OMA	AVNERCE
PhylomeDB	P47811
TreeFam	TF105100
BRENDA	2.7.11.24
Reactome	REACT_188970 REACT_198696 REACT_204811 REACT_205688 REACT_207601 REACT_211125 REACT_215063 REACT_237946 REACT_243212 REACT_250548 REACT_257088 REACT_258600 REACT_259068
SABIO-RK	P47811
ChiTaRS	Mapk14
EvolutionaryTrace	P47811
NextBio	304425
PRO	PR:P47811
Proteomes	UP000000589
Bgee	P47811
CleanEx	MM_MAPK14
ExpressionAtlas	P47811
Genevestigator	P47811
GO	GO:0005623 GO:0005737 GO:0005829 GO:0070062 GO:0005739 GO:0005634 GO:0000922 GO:0005524 GO:0016301 GO:0004707 GO:0051525 GO:0004672 GO:0004674 GO:0001525 GO:0006915 GO:0001502 GO:0000902 GO:0006974 GO:0071479 GO:0071222 GO:0035924 GO:0002062 GO:0000077 GO:0019395 GO:0006006 GO:0035556 GO:0031663 GO:0014835 GO:0090090 GO:0030316 GO:0038066 GO:0018105 GO:0090336 GO:0045648 GO:0045663 GO:1901741 GO:0010831 GO:0042307 GO:2000379 GO:0045944 GO:0006468 GO:0006357 GO:0006355 GO:0032496 GO:0032495 GO:0042770 GO:0007519 GO:0090400 GO:0051146 GO:0006351 GO:0007178 GO:0048010
InterPro	IPR011009 IPR003527 IPR008352 IPR000719 IPR017441 IPR002290
Pfam	PF00069
PRINTS	PR01773
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	PMID:15851690^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	PMID:15851690^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905050	positive regulation of metallopeptidase activity	PMID:15851690^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	PMID:15851690^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:17202865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:17202865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	PMID:17202865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051525	NFAT protein binding	PMID:15304486^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88942	F		Seeded From UniProt	complete
involved_in	GO:0030316	osteoclast differentiation	PMID:15304486^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15304486^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15304486^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15304486^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:15304486^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1901741	positive regulation of myoblast fusion	PMID:22847234^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:22847234^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	PMID:22847234^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:7914033^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
involved_in	GO:0010831	positive regulation of myotube differentiation	PMID:22847234^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:22847234^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10601328^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10601328^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7914033^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16539	F		Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	PMID:17988630^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	PMID:17988630^[7]	ECO:0006054	pharmacological assay evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	PMID:17988630^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	PMID:17988630^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099179	regulation of synaptic membrane adhesion	PMID:17988630^[7]	ECO:0000279	western blot evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17988630^[7]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17988630^[7]	ECO:0006054	pharmacological assay evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17988630^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17988630^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:17988630^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001184	positive regulation of interleukin-12 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900015	regulation of cytokine production involved in inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098586	cellular response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090400	stress-induced premature senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090336	positive regulation of brown fat cell differentiation	PMID:23977283^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071479	cellular response to ionizing radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	PMID:24349514^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:23776175^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:21768366^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1338024	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051403	stress-activated MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051146	striated muscle cell differentiation	PMID:20160094^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109327 MGI:MGI:1918084 MGI:MGI:1926387 MGI:MGI:88355	P		Seeded From UniProt	complete
enables	GO:0048273	mitogen-activated protein kinase p38 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046326	positive regulation of glucose import	PMID:19403598^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:35330)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10943842^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177830	P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	PMID:10943842^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177830	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	PMID:16954198^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035994	response to muscle stretch	PMID:19403598^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:35330)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:12872135^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:15692051^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:12872135^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031281	positive regulation of cyclase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030278	regulation of ossification	PMID:20053668^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019395	fatty acid oxidation	PMID:12802337^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	PMID:18347059^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(MGI:MGI:1920431)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:15767678^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:12808090^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:22897442^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:15890335^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	PMID:18363966^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107191 MGI:MGI:1927616 MGI:MGI:95688	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:20212154^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15937334^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15937334^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15767678^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:20212154^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006006	glucose metabolic process	PMID:12802337^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11884367^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11884367^[29]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	C		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10973481^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:19289495^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:11593045^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16539	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70496	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18347059^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1920431)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10943842^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002062	chondrocyte differentiation	PMID:17644814^[33]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17412) regulates_o_results_in_acquisition_of_features_of:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:21768366^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715522	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:10973481^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177832	P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	PMID:15509711^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:17686994^[35]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107708	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000077	DNA damage checkpoint	PMID:12937170^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:L7RSM2 ensembl:ENSP00000229795	C		Seeded From UniProt	complete
involved_in	GO:2001184	positive regulation of interleukin-12 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0098586	cellular response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0090400	stress-induced premature senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
enables	GO:0048273	mitogen-activated protein kinase p38 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	F		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
involved_in	GO:0031281	positive regulation of cyclase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	F		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16539 ensembl:ENSP00000229795	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR038784	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038784	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration	PMID:20610565^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-451204 Reactome:R-MMU-448961 Reactome:R-MMU-448960 Reactome:R-MMU-448953	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-1605464	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Park, SG et al. (2005) Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. Proc. Natl. Acad. Sci. U.S.A. 102 6356-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Jin, EJ et al. (2006) BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol. Cells 22 353-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Liu, QC et al. (2012) Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis. J Mol Cell Biol 4 386-97 PubMed GONUTS page
↑ ^5.0 ^5.1 Han, J et al. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 808-11 PubMed GONUTS page
↑ ^6.0 ^6.1 Blanco-Aparicio, C et al. (1999) A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. J. Cell Biol. 147 1129-36 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Yasuda, S et al. (2007) Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron 56 456-71 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Choi, HR et al. (2013) Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase. PLoS ONE 8 e72340 PubMed GONUTS page
↑ Lee, H et al. (2013) MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. PLoS ONE 8 e83471 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^12.0 ^12.1 del Barco Barrantes, I et al. (2011) Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc. Natl. Acad. Sci. U.S.A. 108 12764-9 PubMed GONUTS page
↑ Lu, M & Krauss, RS (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc. Natl. Acad. Sci. U.S.A. 107 4212-7 PubMed GONUTS page
↑ ^14.0 ^14.1 Chambers, MA et al. (2009) Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase. J. Physiol. (Lond.) 587 3363-73 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Tamura, K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 221-31 PubMed GONUTS page
↑ Tang, X et al. (2006) LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 103 13777-82 PubMed GONUTS page
↑ ^17.0 ^17.1 Hoebe, K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424 743-8 PubMed GONUTS page
↑ Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page
↑ Su, N et al. (2010) Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum. Mol. Genet. 19 1199-210 PubMed GONUTS page
↑ ^20.0 ^20.1 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page
↑ ^21.0 ^21.1 Yang, TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28 3489-501 PubMed GONUTS page
↑ ^22.0 ^22.1 Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page
↑ Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page
↑ Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
↑ de Angelis, L et al. (2005) Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. Dev. Biol. 283 171-9 PubMed GONUTS page
↑ Itoh, S et al. (2008) Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 13 355-63 PubMed GONUTS page
↑ ^27.0 ^27.1 Cannell, IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc. Natl. Acad. Sci. U.S.A. 107 5375-80 PubMed GONUTS page
↑ ^28.0 ^28.1 Auger, R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J. Biol. Chem. 280 28142-51 PubMed GONUTS page
↑ ^29.0 ^29.1 Baines, CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ. Res. 90 390-7 PubMed GONUTS page
↑ ^30.0 ^30.1 Mudgett, JS et al. (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97 10454-9 PubMed GONUTS page
↑ Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page
↑ Liao, P et al. (2001) The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A. 98 12283-8 PubMed GONUTS page
↑ Kim, JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J. Biol. Chem. 282 29359-67 PubMed GONUTS page
↑ Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page
↑ Barco, R et al. (2007) The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol. Biol. Cell 18 4003-12 PubMed GONUTS page
↑ Yuan, L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J. Biol. Chem. 278 42812-20 PubMed GONUTS page
↑ Lovett, FA et al. (2010) Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation. Endocrinology 151 4368-80 PubMed GONUTS page

[PMID:15851690-1] 1.0 ^1.1 ^1.2 ^1.3 Park, SG et al. (2005) Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. Proc. Natl. Acad. Sci. U.S.A. 102 6356-61 PubMed GONUTS page

[PMID:17202865-2] 2.0 ^2.1 ^2.2 Jin, EJ et al. (2006) BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol. Cells 22 353-9 PubMed GONUTS page

[PMID:15304486-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page

[PMID:22847234-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Liu, QC et al. (2012) Comparative expression profiling identifies differential roles for Myogenin and p38α MAPK signaling in myogenesis. J Mol Cell Biol 4 386-97 PubMed GONUTS page

[PMID:7914033-5] 5.0 ^5.1 Han, J et al. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 808-11 PubMed GONUTS page

[PMID:10601328-6] 6.0 ^6.1 Blanco-Aparicio, C et al. (1999) A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. J. Cell Biol. 147 1129-36 PubMed GONUTS page

[PMID:17988630-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Yasuda, S et al. (2007) Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron 56 456-71 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23977283-9] Choi, HR et al. (2013) Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase. PLoS ONE 8 e72340 PubMed GONUTS page

[PMID:24349514-10] Lee, H et al. (2013) MicroRNA-494, upregulated by tumor necrosis factor-α, desensitizes insulin effect in C2C12 muscle cells. PLoS ONE 8 e83471 PubMed GONUTS page

[PMID:23776175-11] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:21768366-12] 12.0 ^12.1 del Barco Barrantes, I et al. (2011) Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc. Natl. Acad. Sci. U.S.A. 108 12764-9 PubMed GONUTS page

[PMID:20160094-13] Lu, M & Krauss, RS (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc. Natl. Acad. Sci. U.S.A. 107 4212-7 PubMed GONUTS page

[PMID:19403598-14] 14.0 ^14.1 Chambers, MA et al. (2009) Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase. J. Physiol. (Lond.) 587 3363-73 PubMed GONUTS page

[PMID:10943842-15] 15.0 ^15.1 ^15.2 Tamura, K et al. (2000) Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell 102 221-31 PubMed GONUTS page

[PMID:16954198-16] Tang, X et al. (2006) LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 103 13777-82 PubMed GONUTS page

[PMID:12872135-17] 17.0 ^17.1 Hoebe, K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424 743-8 PubMed GONUTS page

[PMID:15692051-18] Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page

[PMID:20053668-19] Su, N et al. (2010) Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum. Mol. Genet. 19 1199-210 PubMed GONUTS page

[PMID:12802337-20] 20.0 ^20.1 Yamauchi, T et al. (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423 762-9 PubMed GONUTS page

[PMID:18347059-21] 21.0 ^21.1 Yang, TT et al. (2008) Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. Mol. Cell. Biol. 28 3489-501 PubMed GONUTS page

[PMID:15767678-22] 22.0 ^22.1 Kelkar, N et al. (2005) Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol. Cell. Biol. 25 2733-43 PubMed GONUTS page

[PMID:12808090-23] Holgado-Madruga, M & Wong, AJ (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol. Cell. Biol. 23 4471-84 PubMed GONUTS page

[PMID:22897442-24] Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page

[PMID:15890335-25] Angelis, L et al. (2005) Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. Dev. Biol. 283 171-9 PubMed GONUTS page

[PMID:18363966-26] Itoh, S et al. (2008) Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells. Genes Cells 13 355-63 PubMed GONUTS page

[PMID:20212154-27] 27.0 ^27.1 Cannell, IG et al. (2010) p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Proc. Natl. Acad. Sci. U.S.A. 107 5375-80 PubMed GONUTS page

[PMID:15937334-28] 28.0 ^28.1 Auger, R et al. (2005) A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death. J. Biol. Chem. 280 28142-51 PubMed GONUTS page

[PMID:11884367-29] 29.0 ^29.1 Baines, CP et al. (2002) Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection. Circ. Res. 90 390-7 PubMed GONUTS page

[PMID:10973481-30] 30.0 ^30.1 Mudgett, JS et al. (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 97 10454-9 PubMed GONUTS page

[PMID:19289495-31] Abell, AN et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol. Cell. Biol. 29 2748-61 PubMed GONUTS page

[PMID:11593045-32] Liao, P et al. (2001) The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A. 98 12283-8 PubMed GONUTS page

[PMID:17644814-33] Kim, JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J. Biol. Chem. 282 29359-67 PubMed GONUTS page

[PMID:15509711-34] Liu, J et al. (2004) Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction 128 643-54 PubMed GONUTS page

[PMID:17686994-35] Barco, R et al. (2007) The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol. Biol. Cell 18 4003-12 PubMed GONUTS page

[PMID:12937170-36] Yuan, L et al. (2003) DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase. J. Biol. Chem. 278 42812-20 PubMed GONUTS page

[PMID:20610565-37] Lovett, FA et al. (2010) Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation. Endocrinology 151 4368-80 PubMed GONUTS page

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MOUSE:MK14

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