MOUSE:MITF

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mitf (synonyms: Bw, Mi, Vit)
Protein Name(s)	Microphthalmia-associated transcription factor
External Links
UniProt	Q08874
EMBL	Z23066 AF222344 AF222959 AF222949 AF222951 AF222953 AF222954 AF222955 AF222956 AF222957 AF222958 AF222959 AF222950 AF222951 AF222953 AF222954 AF222955 AF222956 AF222957 AF222958 AF222959 AF222950 AF222951 AF222956 AF222957 AF222958 AF222959 AF222950 AF222951 AF222956 AF222958 AF222959 AF222950 AF222951 AF222953 AF222954 AF222955 AF222956 AF222957 AF222958 AF222959 AF222949 AF222951 AF222953 AF222954 AF222955 AF222956 AF222957 AF222958 AF222959 AF222949 AF222951 AF222955 AF222956 AF222957 AF222958 AF222952 U19874 U19875 L22958 AB009397
CCDS	CCDS20385.1 CCDS51861.1 CCDS51862.1
PIR	A40728 I49244 PD0026
RefSeq	NP_032627.1 XP_006505758.1
UniGene	Mm.333284 Mm.454504
PDB	4ATH 4ATI 4ATK
PDBsum	4ATH 4ATI 4ATK
ProteinModelPortal	Q08874
SMR	Q08874
BioGrid	201427
IntAct	Q08874
ChEMBL	CHEMBL1075142
PhosphoSite	Q08874
MaxQB	Q08874
PaxDb	Q08874
PRIDE	Q08874
Ensembl	ENSMUST00000043628
GeneID	17342
KEGG	mmu:17342
UCSC	uc009dbe.2
CTD	4286
MGI	MGI:104554
eggNOG	NOG251286
HOVERGEN	HBG006768
InParanoid	Q08874
KO	K09455
PhylomeDB	Q08874
ChiTaRS	Mitf
NextBio	291916
PRO	PR:Q08874
Proteomes	UP000000589
Bgee	Q08874
CleanEx	MM_MITF MM_VIT
ExpressionAtlas	Q08874
Genevestigator	Q08874
GO	GO:0005634 GO:0003682 GO:0003677 GO:0000978 GO:0001077 GO:0000979 GO:0003705 GO:0043565 GO:0003700 GO:0046849 GO:0043010 GO:0044336 GO:0030154 GO:0045165 GO:0030318 GO:0043066 GO:0030316 GO:0043473 GO:0045944 GO:0045893 GO:0042127 GO:0010468 GO:0045670 GO:0006355 GO:0006366 GO:0016055
Gene3D	4.10.280.10
InterPro	IPR011598 IPR021802
Pfam	PF11851 PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0070888	E-box binding	PMID:23207919^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:23207919^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08874	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:23207919^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:23207919^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15716956^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:12575)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15716956^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15716956^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24769727^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9R0G7	P	has_regulation_target:(UniProtKB:P11344)\|has_regulation_target:(UniProtKB:Q60696)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15304486^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104554 PANTHER:PTN000000820	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001141	regulation of RNA biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000144	positive regulation of DNA-templated transcription, initiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046849	bone remodeling	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	has_participant:(EMAPA:19143)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15729346^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98358	P	has_regulation_target:(MGI:MGI:102563)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17442941^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14575687^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045670	regulation of osteoclast differentiation	PMID:11930005^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98511	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045670	regulation of osteoclast differentiation	PMID:11930005^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15576400^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856085	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000148)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12086670^[6]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P10415	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:12086670^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P	occurs_in:(CL:0000148)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:2379821^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	occurs_in:(EMAPA:18769)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	regulates_o_occurs_in:(CL:0000148)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:15576400^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88401	P	results_in_development_of:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030336	negative regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030318	melanocyte differentiation	PMID:12086670^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P	results_in_acquisition_of_features_of:(CL:0000148)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030318	melanocyte differentiation	PMID:2379821^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030318	melanocyte differentiation	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	results_in_acquisition_of_features_of:(CL:0000148)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030316	osteoclast differentiation	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	results_in_acquisition_of_features_of:(CL:0000092)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:9199364^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856094	P	occurs_in:(EMAPA:17525) results_in_acquisition_of_features_of:(CL:0000541)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016055	Wnt signaling pathway	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:12086670^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856095	P	occurs_in:(EMAPA:32782) occurs_in:(CL:0000092) has_regulation_target:(MGI:MGI:88138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006351	transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3092	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14575687^[9]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14575687^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12235125^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:15729346^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:102563)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14575687^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15729346^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:102563)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:23980096^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O75030	P		Seeded From UniProt	complete
involved_in	GO:2001141	regulation of RNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	F		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	C		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O75030 ensembl:ENSP00000391803	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88368 ensembl:ENSRNOP00000044350	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030532	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030532	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR021802 InterPro:IPR024097	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030532	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Pogenberg, V et al. (2012) Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev. 26 2647-58 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Carreira, S et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433 764-9 PubMed GONUTS page
↑ Denecker, G et al. (2014) Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21 1250-61 PubMed GONUTS page
↑ Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 McGill, GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109 707-18 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Lang, D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433 884-7 PubMed GONUTS page
↑ Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Murakami, M et al. (2003) Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. Biochem. Biophys. Res. Commun. 311 4-10 PubMed GONUTS page
↑ ^10.0 ^10.1 Steingrimsson, E et al. (2002) Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc. Natl. Acad. Sci. U.S.A. 99 4477-82 PubMed GONUTS page
↑ ^11.0 ^11.1 Horsford, DJ et al. (2005) Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132 177-87 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Widlund, HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J. Cell Biol. 158 1079-87 PubMed GONUTS page
↑ ^13.0 ^13.1 Moore, KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125 421-30 PubMed GONUTS page
↑ Opdecamp, K et al. (1997) Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development 124 2377-86 PubMed GONUTS page
↑ Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page

[PMID:23207919-1] 1.0 ^1.1 ^1.2 ^1.3 Pogenberg, V et al. (2012) Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF. Genes Dev. 26 2647-58 PubMed GONUTS page

[PMID:15716956-2] 2.0 ^2.1 ^2.2 Carreira, S et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433 764-9 PubMed GONUTS page

[PMID:24769727-3] Denecker, G et al. (2014) Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21 1250-61 PubMed GONUTS page

[PMID:15304486-4] Matsumoto, M et al. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1. J. Biol. Chem. 279 45969-79 PubMed GONUTS page

[PMID:21873635-5] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12086670-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 McGill, GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109 707-18 PubMed GONUTS page

[PMID:15729346-7] 7.0 ^7.1 ^7.2 Lang, D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433 884-7 PubMed GONUTS page

[PMID:17442941-8] Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page

[PMID:14575687-9] 9.0 ^9.1 ^9.2 ^9.3 Murakami, M et al. (2003) Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. Biochem. Biophys. Res. Commun. 311 4-10 PubMed GONUTS page

[PMID:11930005-10] 10.0 ^10.1 Steingrimsson, E et al. (2002) Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc. Natl. Acad. Sci. U.S.A. 99 4477-82 PubMed GONUTS page

[PMID:15576400-11] 11.0 ^11.1 Horsford, DJ et al. (2005) Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity. Development 132 177-87 PubMed GONUTS page

[PMID:12235125-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Widlund, HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J. Cell Biol. 158 1079-87 PubMed GONUTS page

[PMID:2379821-13] 13.0 ^13.1 Moore, KJ et al. (1990) Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics 125 421-30 PubMed GONUTS page

[PMID:9199364-14] Opdecamp, K et al. (1997) Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor. Development 124 2377-86 PubMed GONUTS page

[PMID:23980096-15] Maruyama, K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210 1947-60 PubMed GONUTS page

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MOUSE:MITF

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