PMID:14575687

Citation	Murakami, M, Ikeda, T, Ogawa, K and Funaba, M (2003) Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. Biochem. Biophys. Res. Commun. 311:4-10
Abstract	We explored transcriptional regulation of mouse mast cell protease-9 (mMCP-9), which is implicated in inflammation of the jejunum during helminth infections and tissue remodeling of the uterus during pregnancy. Transcription was positively regulated by microphthalmia-associated transcription factor (MITF), a member of the basic helix-loop-helix-leucine zipper family that binds to the E-box, a CANNTG sequence. The most significant segment for positive regulation by MITF was nt -183 to -177 of the mMCP-9 promoter, CATCATG, which bound MITF-M. In addition, not only other MITF isoforms but also TFE3, another member of the family, activated mMCP-9 transcription through this nucleotide sequence inserted one base within the E-box.
Links	PubMed
Keywords	Amino Acid Motifs; Animals; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Female; Gene Expression Regulation, Enzymologic/physiology; Humans; Male; Mast Cells/chemistry; Mast Cells/enzymology; Melanoma, Experimental/chemistry; Melanoma, Experimental/enzymology; Melanoma, Experimental/genetics; Mice; Microphthalmia-Associated Transcription Factor; Protein Binding; Serine Endopeptidases/chemistry; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Transcription Factors/chemistry; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation/genetics; Transcriptional Activation/physiology; Up-Regulation/physiology
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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