MOUSE:LAMP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Lamp1 (synonyms: Lamp-1)
Protein Name(s)	Lysosome-associated membrane glycoprotein 1 LAMP-1 Lysosome-associated membrane protein 1 120 kDa lysosomal membrane glycoprotein CD107 antigen-like family member A LGP-120 Lysosomal membrane glycoprotein A LGP-A P2B
External Links
UniProt	P11438
EMBL	M32015 M25244 BC049097 J03881
CCDS	CCDS22106.1
PIR	A28067 A60534
RefSeq	NP_001304282.1 NP_034814.2
UniGene	Mm.16716
PDB	5GV0
PDBsum	5GV0
ProteinModelPortal	P11438
SMR	P11438
IntAct	P11438
MINT	P11438
STRING	10090.ENSMUSP00000033824
iPTMnet	P11438
PhosphoSitePlus	P11438
UniCarbKB	P11438
EPD	P11438
PaxDb	P11438
PeptideAtlas	P11438
PRIDE	P11438
Ensembl	ENSMUST00000033824
GeneID	16783
KEGG	mmu:16783
UCSC	uc009kxa.1
CTD	3916
MGI	MGI:96745
eggNOG	KOG4818 ENOG410XQ96
GeneTree	ENSGT00530000063068
HOGENOM	HOG000230942
HOVERGEN	HBG052303
InParanoid	P11438
KO	K06528
OMA	SKEETRC
OrthoDB	EOG091G09EV
PhylomeDB	P11438
TreeFam	TF316339
Reactome	R-MMU-6798695
ChiTaRS	Lamp1
PRO	PR:P11438
Proteomes	UP000000589
Bgee	ENSMUSG00000031447
CleanEx	MM_LAMP1
ExpressionAtlas	P11438
Genevisible	P11438
GO	GO:0097208 GO:0044754 GO:0009986 GO:0044194 GO:0005737 GO:0031410 GO:0005829 GO:0030425 GO:0005768 GO:0010008 GO:0009897 GO:0030285 GO:0005770 GO:0005764 GO:0042470 GO:0005771 GO:0043025 GO:0048471 GO:0045335 GO:0061474 GO:0005886 GO:0042383 GO:0008021 GO:0005773 GO:0031982 GO:0019899 GO:0019904 GO:0048102 GO:0072594 GO:0090160 GO:0008626 GO:0043323 GO:0045954 GO:0050821 GO:1902513 GO:0007283
InterPro	IPR018134 IPR002000
PANTHER	PTHR11506
Pfam	PF01299
PRINTS	PR00336
PROSITE	PS00310 PS00311 PS51407

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0010008	endosome membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05300	C		Seeded From UniProt	complete
part_of	GO:0045335	phagocytic vesicle	PMID:22190682^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:22641697^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9JJ59)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:22641697^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NP78	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16674683^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048102	autophagic cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
part_of	GO:0044754	autolysosome	PMID:26284655^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044194	cytolytic granule	PMID:19915045^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000623)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043323	positive regulation of natural killer cell degranulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	PMID:11266470^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:14506282^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:10787428^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	F		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16973387^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000624)\|part_of:(CL:0000625)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008626	granzyme-mediated apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:15073168^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	PMID:11854359^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:18477453^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:17620357^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:16415873^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:15294975^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:14668490^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:12446704^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:15292400^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:11182090^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:10787428^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:26965651^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:26432893^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:24035762^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32845)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:24029230^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:23926254^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17606) part_of:(CL:0000207)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:18477453^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:16542649^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000117)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:16415873^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:15588329^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17787) part_of:(CL:0000120)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:15294975^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:15006695^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:14643301^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000451)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:14627652^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:12925704^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:11854359^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:11486041^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:10787428^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:23704327^[32]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:23269685^[33]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49129	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:22792322^[34]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	PMID:15292400^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21266579^[35]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902513	regulation of organelle transport along microtubule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
part_of	GO:0097208	alveolar lamellar body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2989	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090160	Golgi to lysosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072594	establishment of protein localization to organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P11279	P		Seeded From UniProt	complete
part_of	GO:0061474	phagolysosome membrane	PMID:23395172^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0090160	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0090160	C		Seeded From UniProt	complete
involved_in	GO:1902513	regulation of organelle transport along microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
involved_in	GO:0090160	Golgi to lysosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
involved_in	GO:0072594	establishment of protein localization to organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	C		Seeded From UniProt	complete
involved_in	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
involved_in	GO:0043323	positive regulation of natural killer cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	F		Seeded From UniProt	complete
involved_in	GO:0008626	granzyme-mediated apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11279 ensembl:ENSP00000333298	C		Seeded From UniProt	complete
part_of	GO:0097208	alveolar lamellar body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
involved_in	GO:0048102	autophagic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0030285	integral component of synaptic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0005773	vacuole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14562 ensembl:ENSRNOP00000026580	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002000	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:18689890^[37]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(EMAPA:17972)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0152	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Madan, R et al. (2012) Salmonella acquires lysosome-associated membrane protein 1 (LAMP1) on phagosomes from Golgi via SipC protein-mediated recruitment of host Syntaxin6. J. Biol. Chem. 287 5574-87 PubMed GONUTS page
↑ ^2.0 ^2.1 Demirel, Ö et al. (2012) The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2. J. Cell. Sci. 125 4230-40 PubMed GONUTS page
↑ Deutsch, D et al. (2006) Amelogenin, a major structural protein in mineralizing enamel, is also expressed in soft tissues: brain and cells of the hematopoietic system. Eur. J. Oral Sci. 114 Suppl 1 183-9; discussion 201-2, 381 PubMed GONUTS page
↑ Varga, RE et al. (2015) In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11. PLoS Genet. 11 e1005454 PubMed GONUTS page
↑ Hoover, RG et al. (2009) Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice. J. Immunol. 183 6913-21 PubMed GONUTS page
↑ Hume, AN et al. (2001) Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J. Cell Biol. 152 795-808 PubMed GONUTS page
↑ Lennon, NJ et al. (2003) Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J. Biol. Chem. 278 50466-73 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Garver, WS et al. (2000) Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J. Lipid Res. 41 673-87 PubMed GONUTS page
↑ Marie, JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 441-54 PubMed GONUTS page
↑ Salazar, G et al. (2004) AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells. J. Biol. Chem. 279 25430-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Lankar, D et al. (2002) Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation. J. Exp. Med. 195 461-72 PubMed GONUTS page
↑ ^12.0 ^12.1 Capurro, MI et al. (2008) Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding. Dev. Cell 14 700-11 PubMed GONUTS page
↑ Stober, CB et al. (2007) Slc11a1, formerly Nramp1, is expressed in dendritic cells and influences major histocompatibility complex class II expression and antigen-presenting cell function. Infect. Immun. 75 5059-67 PubMed GONUTS page
↑ ^14.0 ^14.1 Tabeta, K et al. (2006) The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat. Immunol. 7 156-64 PubMed GONUTS page
↑ ^15.0 ^15.1 Sevilla, LM et al. (2004) Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. J. Immunol. 173 2586-93 PubMed GONUTS page
↑ Richardson, SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol. Biol. Cell 15 1197-210 PubMed GONUTS page
↑ Sun, P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J. Biol. Chem. 278 4063-71 PubMed GONUTS page
↑ ^18.0 ^18.1 Simonsen, A et al. (2004) Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J. Cell. Sci. 117 4239-51 PubMed GONUTS page
↑ Stobrawa, SM et al. (2001) Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron 29 185-96 PubMed GONUTS page
↑ Bartuzi, P et al. (2016) CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun 7 10961 PubMed GONUTS page
↑ Sun, L et al. (2015) Novel Role of TRPML2 in the Regulation of the Innate Immune Response. J. Immunol. 195 4922-32 PubMed GONUTS page
↑ Ouyang, Q et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80 97-112 PubMed GONUTS page
↑ Nagamachi, A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell 24 305-17 PubMed GONUTS page
↑ Kaneko-Goto, T et al. (2013) Goofy coordinates the acuity of olfactory signaling. J. Neurosci. 33 12987-96, 12996a PubMed GONUTS page
↑ Ahtiainen, L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp. Cell Res. 312 1540-53 PubMed GONUTS page
↑ Fossale, E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5 57 PubMed GONUTS page
↑ Aula, N et al. (2004) Sialin expression in the CNS implicates extralysosomal function in neurons. Neurobiol. Dis. 15 251-61 PubMed GONUTS page
↑ Yada, A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell. Immunol. 225 21-32 PubMed GONUTS page
↑ Fortun, J et al. (2003) Emerging role for autophagy in the removal of aggresomes in Schwann cells. J. Neurosci. 23 10672-80 PubMed GONUTS page
↑ Chakrabarti, S et al. (2003) Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J. Cell Biol. 162 543-9 PubMed GONUTS page
↑ Plitz, T & Pfeffer, K (2001) Intact lysosome transport and phagosome function despite kinectin deficiency. Mol. Cell. Biol. 21 6044-55 PubMed GONUTS page
↑ Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page
↑ Kato, U et al. (2013) Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J. Biol. Chem. 288 4922-34 PubMed GONUTS page
↑ Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page
↑ Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page
↑ White, C et al. (2013) HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 17 261-70 PubMed GONUTS page
↑ Turner, LM et al. (2008) Comparative analysis of testis protein evolution in rodents. Genetics 179 2075-89 PubMed GONUTS page

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[PMID:14668490-16] Richardson, SC et al. (2004) Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol. Biol. Cell 15 1197-210 PubMed GONUTS page

[PMID:12446704-17] Sun, P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J. Biol. Chem. 278 4063-71 PubMed GONUTS page

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[PMID:11182090-19] Stobrawa, SM et al. (2001) Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron 29 185-96 PubMed GONUTS page

[PMID:26965651-20] Bartuzi, P et al. (2016) CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun 7 10961 PubMed GONUTS page

[PMID:26432893-21] Sun, L et al. (2015) Novel Role of TRPML2 in the Regulation of the Innate Immune Response. J. Immunol. 195 4922-32 PubMed GONUTS page

[PMID:24035762-22] Ouyang, Q et al. (2013) Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development. Neuron 80 97-112 PubMed GONUTS page

[PMID:24029230-23] Nagamachi, A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell 24 305-17 PubMed GONUTS page

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[PMID:16542649-25] Ahtiainen, L et al. (2006) Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing. Exp. Cell Res. 312 1540-53 PubMed GONUTS page

[PMID:15588329-26] Fossale, E et al. (2004) Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis. BMC Neurosci 5 57 PubMed GONUTS page

[PMID:15006695-27] Aula, N et al. (2004) Sialin expression in the CNS implicates extralysosomal function in neurons. Neurobiol. Dis. 15 251-61 PubMed GONUTS page

[PMID:14643301-28] Yada, A et al. (2003) Accelerated antigen presentation and elicitation of humoral response in vivo by FcgammaRIIB- and FcgammaRI/III-mediated immune complex uptake. Cell. Immunol. 225 21-32 PubMed GONUTS page

[PMID:14627652-29] Fortun, J et al. (2003) Emerging role for autophagy in the removal of aggresomes in Schwann cells. J. Neurosci. 23 10672-80 PubMed GONUTS page

[PMID:12925704-30] Chakrabarti, S et al. (2003) Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J. Cell Biol. 162 543-9 PubMed GONUTS page

[PMID:11486041-31] Plitz, T & Pfeffer, K (2001) Intact lysosome transport and phagosome function despite kinectin deficiency. Mol. Cell. Biol. 21 6044-55 PubMed GONUTS page

[PMID:23704327-32] Papal, S et al. (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum. Mol. Genet. 22 3773-88 PubMed GONUTS page

[PMID:23269685-33] Kato, U et al. (2013) Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. J. Biol. Chem. 288 4922-34 PubMed GONUTS page

[PMID:22792322-34] Fusco, C et al. (2012) The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS ONE 7 e40440 PubMed GONUTS page

[PMID:21266579-35] Watanabe, A et al. (2011) Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation. J. Biol. Chem. 286 10702-11 PubMed GONUTS page

[PMID:23395172-36] White, C et al. (2013) HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab. 17 261-70 PubMed GONUTS page

[PMID:18689890-37] Turner, LM et al. (2008) Comparative analysis of testis protein evolution in rodents. Genetics 179 2075-89 PubMed GONUTS page

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MOUSE:LAMP1

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