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PMID:18689890

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Citation

Turner, LM, Chuong, EB and Hoekstra, HE (2008) Comparative analysis of testis protein evolution in rodents. Genetics 179:2075-89

Abstract

Genes expressed in testes are critical to male reproductive success, affecting spermatogenesis, sperm competition, and sperm-egg interaction. Comparing the evolution of testis proteins at different taxonomic levels can reveal which genes and functional classes are targets of natural and sexual selection and whether the same genes are targets among taxa. Here we examine the evolution of testis-expressed proteins at different levels of divergence among three rodents, mouse (Mus musculus), rat (Rattus norvegicus), and deer mouse (Peromyscus maniculatus), to identify rapidly evolving genes. Comparison of expressed sequence tags (ESTs) from testes suggests that proteins with testis-specific expression evolve more rapidly on average than proteins with maximal expression in other tissues. Genes with the highest rates of evolution have a variety of functional roles including signal transduction, DNA binding, and egg-sperm interaction. Most of these rapidly evolving genes have not been identified previously as targets of selection in comparisons among more divergent mammals. To determine if these genes are evolving rapidly among closely related species, we sequenced 11 of these genes in six Peromyscus species and found evidence for positive selection in five of them. Together, these results demonstrate rapid evolution of functionally diverse testis-expressed proteins in rodents, including the identification of amino acids under lineage-specific selection in Peromyscus. Evidence for positive selection among closely related species suggests that changes in these proteins may have consequences for reproductive isolation.

Links

PubMed PMC2516081 Online version:10.1534/genetics.107.085902

Keywords

Amino Acid Sequence; Animals; Evolution, Molecular; Expressed Sequence Tags; Genome; Male; Mice; Molecular Sequence Data; Peromyscus/genetics; Proteins/genetics; Rats; Rodentia/genetics; Selection, Genetic; Sequence Alignment; Spermatogenesis/genetics; Testis/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:CTSRB

part_of

GO:0034702: ion channel complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

  • part_of:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:CTSRB

acts_upstream_of_or_within

GO:0048240: sperm capacitation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:LAMP1

acts_upstream_of_or_within

GO:0007283: spermatogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:MCSP

acts_upstream_of_or_within

GO:0030317: flagellated sperm motility

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SP17

acts_upstream_of_or_within

GO:0007339: binding of sperm to zona pellucida

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:H1FNT

acts_upstream_of_or_within

GO:0030261: chromosome condensation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:H1FNT

acts_upstream_of_or_within

GO:0006997: nucleus organization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

MOUSE:EQTN

acts_upstream_of_or_within

GO:0001675: acrosome assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:HILS1

acts_upstream_of_or_within

GO:0030261: chromosome condensation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:HILS1

acts_upstream_of_or_within

GO:0007283: spermatogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

  • occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:LAMP1

acts_upstream_of_or_within

GO:0007283: spermatogenesis

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

occurs_in:(EMAPA:17972)

Seeded From UniProt

complete


See also

References

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