MOUSE:KPCB

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkcb (synonyms: Pkcb, Prkcb1)
Protein Name(s)	Protein kinase C beta type PKC-B PKC-beta
External Links
UniProt	P68404
EMBL	X53532 X59274 AC016522 AC122232 AC123837 AC151986 BC127083
CCDS	CCDS21815.1 CCDS85402.1
PIR	S11213
RefSeq	NP_001303601.1 NP_032881.1
UniGene	Mm.207496 Mm.446371
ProteinModelPortal	P68404
SMR	P68404
BioGrid	202195
DIP	DIP-31583N
IntAct	P68404
MINT	MINT-98059
STRING	10090.ENSMUSP00000070019
iPTMnet	P68404
PhosphoSitePlus	P68404
SwissPalm	P68404
EPD	P68404
MaxQB	P68404
PaxDb	P68404
PeptideAtlas	P68404
PRIDE	P68404
Ensembl	ENSMUST00000064921 ENSMUST00000064989 ENSMUST00000143692
GeneID	18751
KEGG	mmu:18751
UCSC	uc009jot.1 uc009jou.1
CTD	5579
MGI	MGI:97596
eggNOG	KOG0694 ENOG410XNPH
GeneTree	ENSGT00820000126964
HOGENOM	HOG000233022
HOVERGEN	HBG108317
InParanoid	P68404
KO	K19662
OMA	QAHIDRE
OrthoDB	EOG091G0QRS
TreeFam	TF351133
BRENDA	2.7.11.13
Reactome	[www.reactome.org/content/detail/R-MMU-114516 R-MMU-114516] [www.reactome.org/content/detail/R-MMU-1169091 R-MMU-1169091] [www.reactome.org/content/detail/R-MMU-416993 R-MMU-416993] [www.reactome.org/content/detail/R-MMU-4419969 R-MMU-4419969] [www.reactome.org/content/detail/R-MMU-5099900 R-MMU-5099900] [www.reactome.org/content/detail/R-MMU-5218921 R-MMU-5218921] [www.reactome.org/content/detail/R-MMU-76005 R-MMU-76005]
ChiTaRS	Prkcb
PRO	PR:P68404
Proteomes	UP000000589
Bgee	ENSMUSG00000052889
Genevisible	P68404
GO	GO:0005737 GO:0005829 GO:0070062 GO:0016020 GO:0005654 GO:0005634 GO:0005886 GO:0050681 GO:0005524 GO:0005246 GO:0003682 GO:0042393 GO:0035403 GO:0030374 GO:0004697 GO:0005080 GO:0004674 GO:0008270 GO:0002250 GO:0006915 GO:0042113 GO:0050853 GO:0006816 GO:0006874 GO:0071322 GO:0035408 GO:0035556 GO:0010829 GO:0046627 GO:0018105 GO:0045766 GO:0050861 GO:0043123 GO:0051092 GO:0030949 GO:0006468 GO:0006357 GO:0001666 GO:0006351
CDD	cd00029
Gene3D	2.60.40.150
InterPro	IPR000961 IPR000008 IPR020454 IPR011009 IPR002219 IPR017892 IPR000719 IPR017441 IPR014375 IPR008271
Pfam	PF00130 PF00168 PF00069 PF00433
PIRSF	PIRSF000550
PRINTS	PR00360 PR00008
SMART	SM00109 SM00239 SM00133 SM00220
SUPFAM	SSF49562 SSF56112
PROSITE	PS51285 PS50004 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008091	spectrin	PMID:10534118^[1]	ECO:0000314			C		Fig. 5. PKC beta II is concentrated within caps of spectrin in B cells. B cells from BALB/c (a), lpr (b), or anti-ssDNA transgenic mice were stained using rabbit anti-spectrin antibody detected with donkey anti-rabbit fluorescein,followed by biotinylated mouse anti-PKC beta-II antibody detected with streptavidin Texas red. Arrows indicate PKC beta-II enriched in the submembranous region of B cells with capped spectrin. The image shown here is the summation of confocal images collected at 2-μm intervals. Left side of image, spectrin staining. Right side of image, PKC beta-II staining of the same field of cells. PKC Beta II is an isoform of the the protein KPCB	complete CACAO 12327
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:16301747^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050861	positive regulation of B cell receptor signaling pathway	PMID:16301747^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:12118249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P68403	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:11805327^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12118249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	PMID:12118249^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035408	histone H3-T6 phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	P		Seeded From UniProt	complete
enables	GO:0035403	histone kinase activity (H3-T6 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:11805327^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:0010829	negative regulation of glucose transmembrane transport	PMID:10499500^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:21658591^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0044305) part_of:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071322	cellular response to carbohydrate stimulus	PMID:16585392^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046627	negative regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040008	regulation of growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035408	histone H3-T6 phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	P		Seeded From UniProt	complete
enables	GO:0035403	histone kinase activity (H3-T6 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	C		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014059	regulation of dopamine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:11880265^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:11880265^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:15545601^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12618484^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14613966^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12826667^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14613966^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	C		Seeded From UniProt	complete
enables	GO:0005246	calcium channel regulator activity	PMID:11880265^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:15545601^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:12618484^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3396	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23775122^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:109334)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05771	F		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030374	P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0030374	P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030374	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
involved_in	GO:0035408	histone H3-T6 phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	P		Seeded From UniProt	complete
enables	GO:0035403	histone kinase activity (H3-T6 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05771 ensembl:ENSP00000496129	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014375 InterPro:IPR034664	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR014375 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR014375 InterPro:IPR017892 InterPro:IPR034664	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014375	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:18323529^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Masso-Welch, PA et al. (1999) Polarized expression of immunoglobulin, spectrin, and protein kinase C beta II occurs in B cells from normal BALB/c, autoimmune lpr, and anti-ssDNA transgenic, tolerant mice. J. Leukoc. Biol. 66 617-24 PubMed GONUTS page
↑ ^2.0 ^2.1 Shinohara, H et al. (2005) PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J. Exp. Med. 202 1423-31 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Su, TT et al. (2002) PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 3 780-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Suzuma, K et al. (2002) Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 99 721-6 PubMed GONUTS page
↑ Standaert, ML et al. (1999) Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. Endocrinology 140 4470-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Fioravante, D et al. (2011) Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron 70 1005-19 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Alden, KJ et al. (2002) Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. Am. J. Physiol., Cell Physiol. 282 C768-74 PubMed GONUTS page
↑ ^10.0 ^10.1 Aiba, Y et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc. Natl. Acad. Sci. U.S.A. 101 16612-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Cogram, P et al. (2004) Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum. Mol. Genet. 13 7-14 PubMed GONUTS page
↑ Wang, WL et al. (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J. Biol. Chem. 278 37705-12 PubMed GONUTS page
↑ Park, K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol. Cell. Biol. 33 3227-41 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page

[PMID:10534118-1] Masso-Welch, PA et al. (1999) Polarized expression of immunoglobulin, spectrin, and protein kinase C beta II occurs in B cells from normal BALB/c, autoimmune lpr, and anti-ssDNA transgenic, tolerant mice. J. Leukoc. Biol. 66 617-24 PubMed GONUTS page

[PMID:16301747-2] 2.0 ^2.1 Shinohara, H et al. (2005) PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J. Exp. Med. 202 1423-31 PubMed GONUTS page

[PMID:12118249-3] 3.0 ^3.1 ^3.2 Su, TT et al. (2002) PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 3 780-6 PubMed GONUTS page

[PMID:11805327-4] 4.0 ^4.1 Suzuma, K et al. (2002) Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 99 721-6 PubMed GONUTS page

[PMID:10499500-5] Standaert, ML et al. (1999) Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. Endocrinology 140 4470-7 PubMed GONUTS page

[PMID:21658591-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Fioravante, D et al. (2011) Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron 70 1005-19 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16585392-8] Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page

[PMID:11880265-9] 9.0 ^9.1 ^9.2 Alden, KJ et al. (2002) Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. Am. J. Physiol., Cell Physiol. 282 C768-74 PubMed GONUTS page

[PMID:15545601-10] 10.0 ^10.1 Aiba, Y et al. (2004) Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc. Natl. Acad. Sci. U.S.A. 101 16612-7 PubMed GONUTS page

[PMID:12618484-11] 11.0 ^11.1 Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page

[PMID:14613966-12] 12.0 ^12.1 Cogram, P et al. (2004) Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum. Mol. Genet. 13 7-14 PubMed GONUTS page

[PMID:12826667-13] Wang, WL et al. (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J. Biol. Chem. 278 37705-12 PubMed GONUTS page

[PMID:23775122-14] Park, K et al. (2013) Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Mol. Cell. Biol. 33 3227-41 PubMed GONUTS page

[PMID:18323529-15] 15.0 ^15.1 ^15.2 ^15.3 Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page

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