MOUSE:KPCA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Prkca (synonyms: Pkca)
Protein Name(s)	Protein kinase C alpha type PKC-A PKC-alpha
External Links
UniProt	P20444
EMBL	M25811 X52685 X52684
PIR	S07104
RefSeq	NP_035231.2
UniGene	Mm.222178
ProteinModelPortal	P20444
SMR	P20444
BioGrid	202194
DIP	DIP-532N
IntAct	P20444
MINT	MINT-98140
BindingDB	P20444
ChEMBL	CHEMBL2567
PhosphoSite	P20444
MaxQB	P20444
PaxDb	P20444
PRIDE	P20444
GeneID	18750
KEGG	mmu:18750
CTD	5578
MGI	MGI:97595
eggNOG	COG0515
HOGENOM	HOG000233022
HOVERGEN	HBG108317
InParanoid	P20444
KO	K02677
PhylomeDB	P20444
BRENDA	2.7.11.13
ChiTaRS	Prkca
NextBio	294917
PRO	PR:P20444
Proteomes	UP000000589
CleanEx	MM_PRKCA
Genevestigator	P20444
GO	GO:0045177 GO:0005737 GO:0030425 GO:0016020 GO:0031966 GO:0005739 GO:0043025 GO:0005634 GO:0048471 GO:0001750 GO:0005886 GO:0005524 GO:0004698 GO:0004697 GO:0004674 GO:0008270 GO:0001525 GO:0007155 GO:0006874 GO:0071322 GO:0002062 GO:0000188 GO:0050930 GO:0097193 GO:0008285 GO:0034351 GO:0046325 GO:0046627 GO:0006469 GO:0001933 GO:0030593 GO:0036289 GO:0045766 GO:0010613 GO:0045785 GO:0030335 GO:2000707 GO:0010595 GO:0001938 GO:0070374 GO:0050729 GO:0031666 GO:0045651 GO:0045931 GO:0001934 GO:0006468 GO:0006937 GO:0050730 GO:0090330 GO:0002026
Gene3D	2.60.40.150
InterPro	IPR000961 IPR000008 IPR020454 IPR011009 IPR002219 IPR017892 IPR000719 IPR017441 IPR014375 IPR002290 IPR008271
Pfam	PF00130 PF00168 PF00069 PF00433
PIRSF	PIRSF000550
PRINTS	PR00360 PR00008
SMART	SM00109 SM00239 SM00133 SM00220
SUPFAM	SSF49562 SSF56112
PROSITE	PS51285 PS50004 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004697	protein kinase C activity	PMID:23099255^[1]	ECO:0000314			F		Figure 5 shows the effect of euphol (100 μg/ear) on TPA-induced PKC activation. B shows alpha activation.	complete CACAO 5465
involved_in	GO:0045780	positive regulation of bone resorption	PMID:16014375^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000092)	Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:16014375^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O54890	F	occurs_in:(CL:0000092)	Seeded From UniProt	complete
part_of	GO:0035866	alphav-beta3 integrin-PKCalpha complex	PMID:16014375^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000092)	Seeded From UniProt	complete
involved_in	GO:0047484	regulation of response to osmotic stress	PMID:7828597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:7828597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004698	calcium-dependent protein kinase C activity	PMID:7828597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010360	negative regulation of anion channel activity	PMID:7828597^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:23099255^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000707	positive regulation of dense core granule biogenesis	PMID:19147982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:19147982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05696	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05696	C		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0045651	positive regulation of macrophage differentiation	PMID:9508782^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034351	negative regulation of glial cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P05696	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:2000300	regulation of synaptic vesicle exocytosis	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099523	presynaptic cytosol	PMID:21658591^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0044305) part_of:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099171	presynaptic modulation of chemical synaptic transmission	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0044305) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044305	calyx of Held	PMID:21658591^[6]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097193	intrinsic apoptotic signaling pathway	PMID:12928424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090330	regulation of platelet aggregation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071322	cellular response to carbohydrate stimulus	PMID:16585392^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051965	positive regulation of synapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050930	induction of positive chemotaxis	PMID:12928424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	PMID:11940581^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	PMID:12928424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029711	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048259	regulation of receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:11923480^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679305	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046325	negative regulation of glucose import	PMID:11923480^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679305	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045921	positive regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045822	negative regulation of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	PMID:23863479^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12115694^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000604)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036289	peptidyl-serine autophosphorylation	PMID:16814779^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17787)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035408	histone H3-T6 phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
enables	GO:0035403	histone kinase activity (H3-T6 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034351	negative regulation of glial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:27353086^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032355	response to estradiol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	PMID:12928424^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029711	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:12115694^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000604)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:18265009^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021955	central nervous system neuron axonogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:18323529^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	PMID:27353086^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17956267^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88039	P	regulates_o_occurs_in:(EMAPA:32874)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006937	regulation of muscle contraction	PMID:14966518^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3037088	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:14966518^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3037088	P	occurs_in:(EMAPA:16105) occurs_in:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	PMID:11923480^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679305	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:7741753^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12618484^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10882525^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16040)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12826667^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23824537^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15590069^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000025)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14613966^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12928424^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12826667^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10882525^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036)\|part_of:(EMAPA:16037)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15590069^[25]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000365)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14613966^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10882525^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036)\|part_of:(EMAPA:16037)	Seeded From UniProt	complete
enables	GO:0004698	calcium-dependent protein kinase C activity	PMID:7741753^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004698	calcium-dependent protein kinase C activity	PMID:10879655^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004698	calcium-dependent protein kinase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:12970181^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	PMID:12618484^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14966518^[19]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1889595)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002159	desmosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002062	chondrocyte differentiation	PMID:17644814^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17412) regulates_o_results_in_acquisition_of_features_of:(CL:0000134)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002026	regulation of the force of heart contraction	PMID:14966518^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3037088	P	regulates_o_has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P17252	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:14966518^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3037088	P	regulates_o_occurs_in:(EMAPA:16105) regulates_o_has_input:(MGI:MGI:88110)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	PMID:24305805^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1927223	P	regulates_o_has_input:(MGI:MGI:108476)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	PMID:14966518^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3037088	P	regulates_o_occurs_in:(EMAPA:16105) regulates_o_has_input:(MGI:MGI:97622)	Seeded From UniProt	complete
part_of	GO:0001750	photoreceptor outer segment	PMID:10813773^[31]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000573)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3395	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000188	inactivation of MAPK activity	PMID:11923480^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679305	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014375 InterPro:IPR034663	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR014375 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR014375 InterPro:IPR017892 InterPro:IPR034663	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014375	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9010658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Passos, GF et al. (2013) The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. Eur. J. Pharmacol. 698 413-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Rucci, N et al. (2005) A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J. Cell. Sci. 118 3263-75 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Hardy, SP et al. (1995) Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 14 68-75 PubMed GONUTS page
↑ ^4.0 ^4.1 Konopatskaya, O et al. (2009) PKCalpha regulates platelet granule secretion and thrombus formation in mice. J. Clin. Invest. 119 399-407 PubMed GONUTS page
↑ Pierce, A et al. (1998) An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events. J. Cell Biol. 140 1511-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Fioravante, D et al. (2011) Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron 70 1005-19 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Cataisson, C et al. (2003) Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. J. Immunol. 171 2703-13 PubMed GONUTS page
↑ Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page
↑ Saito, Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277 23216-22 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Leitges, M et al. (2002) Knockout of PKC alpha enhances insulin signaling through PI3K. Mol. Endocrinol. 16 847-58 PubMed GONUTS page
↑ Lavado, A et al. (2013) Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140 3323-34 PubMed GONUTS page
↑ ^13.0 ^13.1 Jellali, A et al. (2002) Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. J. Comp. Neurol. 449 76-87 PubMed GONUTS page
↑ Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page
↑ ^15.0 ^15.1 Lange, S et al. (2016) MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun 7 12120 PubMed GONUTS page
↑ Fujino, T et al. (2008) cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. J. Comp. Neurol. 507 1831-45 PubMed GONUTS page
↑ Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page
↑ Leitges, M (2007) Functional PKC in vivo analysis using deficient mouse models. Biochem. Soc. Trans. 35 1018-20 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Braz, JC et al. (2004) PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat. Med. 10 248-54 PubMed GONUTS page
↑ ^20.0 ^20.1 Melloni, E et al. (1995) Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain. Biochem. Biophys. Res. Commun. 210 82-9 PubMed GONUTS page
↑ ^21.0 ^21.1 Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Pauken, CM & Capco, DG (2000) The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev. Biol. 223 411-21 PubMed GONUTS page
↑ ^23.0 ^23.1 Wang, WL et al. (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J. Biol. Chem. 278 37705-12 PubMed GONUTS page
↑ Lorthongpanich, C et al. (2013) Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 27 1441-6 PubMed GONUTS page
↑ ^25.0 ^25.1 Halet, G (2004) PKC signaling at fertilization in mammalian eggs. Biochim. Biophys. Acta 1742 185-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Cogram, P et al. (2004) Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum. Mol. Genet. 13 7-14 PubMed GONUTS page
↑ Balasubramanian, G et al. () Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. J. Craniofac. Genet. Dev. Biol. 20 26-34 PubMed GONUTS page
↑ Lafuente, MJ et al. (2003) Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J. 22 4689-98 PubMed GONUTS page
↑ Kim, JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J. Biol. Chem. 282 29359-67 PubMed GONUTS page
↑ Onishi, K et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J. Neurosci. 33 19071-85 PubMed GONUTS page
↑ Hirano, AA et al. (2000) Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina. J. Comp. Neurol. 421 80-94 PubMed GONUTS page

[PMID:23099255-1] 1.0 ^1.1 Passos, GF et al. (2013) The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice. Eur. J. Pharmacol. 698 413-20 PubMed GONUTS page

[PMID:16014375-2] 2.0 ^2.1 ^2.2 Rucci, N et al. (2005) A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J. Cell. Sci. 118 3263-75 PubMed GONUTS page

[PMID:7828597-3] 3.0 ^3.1 ^3.2 ^3.3 Hardy, SP et al. (1995) Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 14 68-75 PubMed GONUTS page

[PMID:19147982-4] 4.0 ^4.1 Konopatskaya, O et al. (2009) PKCalpha regulates platelet granule secretion and thrombus formation in mice. J. Clin. Invest. 119 399-407 PubMed GONUTS page

[PMID:9508782-5] Pierce, A et al. (1998) An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks macrophage colony-stimulating factor-stimulated signaling events. J. Cell Biol. 140 1511-8 PubMed GONUTS page

[PMID:21658591-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Fioravante, D et al. (2011) Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held. Neuron 70 1005-19 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12928424-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Cataisson, C et al. (2003) Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. J. Immunol. 171 2703-13 PubMed GONUTS page

[PMID:16585392-9] Itoh, S et al. (2006) Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium. Circulation 113 1787-98 PubMed GONUTS page

[PMID:11940581-10] Saito, Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J. Biol. Chem. 277 23216-22 PubMed GONUTS page

[PMID:11923480-11] 11.0 ^11.1 ^11.2 ^11.3 Leitges, M et al. (2002) Knockout of PKC alpha enhances insulin signaling through PI3K. Mol. Endocrinol. 16 847-58 PubMed GONUTS page

[PMID:23863479-12] Lavado, A et al. (2013) Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators. Development 140 3323-34 PubMed GONUTS page

[PMID:12115694-13] 13.0 ^13.1 Jellali, A et al. (2002) Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. J. Comp. Neurol. 449 76-87 PubMed GONUTS page

[PMID:16814779-14] Miyazaki, T et al. (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett. 580 4057-64 PubMed GONUTS page

[PMID:27353086-15] 15.0 ^15.1 Lange, S et al. (2016) MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy. Nat Commun 7 12120 PubMed GONUTS page

[PMID:18265009-16] Fujino, T et al. (2008) cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. J. Comp. Neurol. 507 1831-45 PubMed GONUTS page

[PMID:18323529-17] Chang, JS et al. (2008) Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end products. Circ. Res. 102 905-13 PubMed GONUTS page

[PMID:17956267-18] Leitges, M (2007) Functional PKC in vivo analysis using deficient mouse models. Biochem. Soc. Trans. 35 1018-20 PubMed GONUTS page

[PMID:14966518-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 Braz, JC et al. (2004) PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat. Med. 10 248-54 PubMed GONUTS page

[PMID:7741753-20] 20.0 ^20.1 Melloni, E et al. (1995) Identity in molecular structure between "differentiation enhancing factor" of murine erythroleukemia cells and the 30 kD heparin-binding protein of developing rat brain. Biochem. Biophys. Res. Commun. 210 82-9 PubMed GONUTS page

[PMID:12618484-21] 21.0 ^21.1 Chen, S et al. (2003) Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells. Int. Immunol. 15 403-9 PubMed GONUTS page

[PMID:10882525-22] 22.0 ^22.1 ^22.2 Pauken, CM & Capco, DG (2000) The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev. Biol. 223 411-21 PubMed GONUTS page

[PMID:12826667-23] 23.0 ^23.1 Wang, WL et al. (2003) PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J. Biol. Chem. 278 37705-12 PubMed GONUTS page

[PMID:23824537-24] Lorthongpanich, C et al. (2013) Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation. Genes Dev. 27 1441-6 PubMed GONUTS page

[PMID:15590069-25] 25.0 ^25.1 Halet, G (2004) PKC signaling at fertilization in mammalian eggs. Biochim. Biophys. Acta 1742 185-9 PubMed GONUTS page

[PMID:14613966-26] 26.0 ^26.1 Cogram, P et al. (2004) Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum. Mol. Genet. 13 7-14 PubMed GONUTS page

[PMID:10879655-27] Balasubramanian, G et al. () Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. J. Craniofac. Genet. Dev. Biol. 20 26-34 PubMed GONUTS page

[PMID:12970181-28] Lafuente, MJ et al. (2003) Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J. 22 4689-98 PubMed GONUTS page

[PMID:17644814-29] Kim, JS et al. (2007) Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells. J. Biol. Chem. 282 29359-67 PubMed GONUTS page

[PMID:24305805-30] Onishi, K et al. (2013) Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J. Neurosci. 33 19071-85 PubMed GONUTS page

[PMID:10813773-31] Hirano, AA et al. (2000) Cloning and immunocytochemical localization of a cyclic nucleotide-gated channel alpha-subunit to all cone photoreceptors in the mouse retina. J. Comp. Neurol. 421 80-94 PubMed GONUTS page

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