MOUSE:INSR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Insr
Protein Name(s)	Insulin receptor IR Insulin receptor subunit alpha Insulin receptor subunit beta
External Links
UniProt	P15208
EMBL	J05149 AC168068 M28869
CCDS	CCDS22059.1
PIR	A34157
RefSeq	NP_034698.2
UniGene	Mm.268003
PDB	1LK2
PDBsum	1LK2
ProteinModelPortal	P15208
SMR	P15208
BioGrid	200774
DIP	DIP-41452N
IntAct	P15208
MINT	MINT-1516207
ChEMBL	CHEMBL3187
PhosphoSite	P15208
MaxQB	P15208
PaxDb	P15208
PRIDE	P15208
Ensembl	ENSMUST00000091291
GeneID	16337
KEGG	mmu:16337
CTD	3643
MGI	MGI:96575
eggNOG	COG0515
GeneTree	ENSGT00760000118818
HOGENOM	HOG000038045
HOVERGEN	HBG006134
InParanoid	P15208
KO	K04527
OMA	CPERVTD
OrthoDB	EOG73RB9N
TreeFam	TF351636
BRENDA	2.7.10.1
Reactome	REACT_233181 REACT_240250 REACT_244029 REACT_246380 REACT_261478
ChiTaRS	Insr
EvolutionaryTrace	P15208
NextBio	289438
PRO	PR:P15208
Proteomes	UP000000589
CleanEx	MM_INSR
ExpressionAtlas	P15208
Genevestigator	P15208
GO	GO:0005901 GO:0070062 GO:0005899 GO:0016020 GO:0005886 GO:0043235 GO:0005524 GO:0005525 GO:0043559 GO:0043560 GO:0005009 GO:0043548 GO:0051425 GO:0004716 GO:0000187 GO:0032148 GO:0071363 GO:0008544 GO:0031017 GO:0007186 GO:0042593 GO:0003007 GO:0008286 GO:0030238 GO:0009887 GO:0038083 GO:0030335 GO:0048639 GO:0045740 GO:0045725 GO:0045821 GO:0045840 GO:0045429 GO:0051897 GO:0060267 GO:0046777 GO:0051290 GO:0045995 GO:0006355 GO:0019087
Gene3D	2.60.40.10 3.80.20.20
InterPro	IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF56112 SSF57184
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030325	adrenal gland development	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		Figure 6 shows that mice with an absence of Insr and Igf1r, through knockout, presented with adrenal agenesis.	complete CACAO 6576
	GO:0048639	positive regulation of developmental growth	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		Figure 1 shows that mice with the absence of Insulin receptor protein, due to gene knockout, experienced growth retardation.	complete CACAO 6577
	GO:0008584	male gonad development	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		Figures 1 and 2 show that mice without INSR, due to gene knockout, experienced male to female sex reversal and disrupted testicular development.	complete CACAO 6580
	GO:2000194	regulation of female gonad development	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		Figure 3 shows that mice without INSR, due to gene knockout, experienced delayed ovarian differentiation.	complete CACAO 6581
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		Fig 6 show that IGF1R and INSR positively regulate SF1 expression through gene interaction.	complete CACAO 6822
	GO:0051446	positive regulation of meiotic cell cycle	PMID:23300479^[1]	ECO:0000316		UniProtKB:Q60751	P		FIg 4 shows that IGF1R and INSR positively regulate the meiotic cell cycle. When IGF1R and INSR are absent, the speed of cells entering into meiosis is delayed.	complete CACAO 6823
involved_in	GO:0051446	positive regulation of meiotic cell cycle	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:2000194	regulation of female gonad development	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	PMID:23300479^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:20032056^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:9447983^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346037 MGI:MGI:96433 MGI:MGI:96575 PANTHER:PTN002521379 RGD:2869 RGD:2917 UniProtKB:P06213 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-020503-3 ZFIN:ZDB-GENE-020503-4	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213 UniProtKB:P08069	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 MGI:MGI:96433 PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 WB:WBGene00000898	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 PANTHER:PTN000699611 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2917 UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990535	neuron projection maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097242	amyloid-beta clearance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097062	dendritic spine maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	PMID:19744960^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060267	positive regulation of respiratory burst	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048639	positive regulation of developmental growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046326	positive regulation of glucose import	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045995	regulation of embryonic development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	PMID:23906066^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045821	positive regulation of glycolytic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0043423	3-phosphoinositide-dependent protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043243	positive regulation of protein complex disassembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:10100151^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
enables	GO:0038024	cargo receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034612	response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032869	cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0032809	neuronal cell body membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032410	negative regulation of transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032148	activation of protein kinase B activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032147	activation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
enables	GO:0031995	insulin-like growth factor II binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
colocalizes_with	GO:0031981	nuclear lumen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
enables	GO:0031405	lipoic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031017	exocrine pancreas development	PMID:12101187^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857204	P	results_in_development_of:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030238	male sex determination	PMID:14628051^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857204	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019087	transformation of host cell by virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010560	positive regulation of glycoprotein biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010310	regulation of hydrogen peroxide metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12101187^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857204	P	has_participant:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:23906066^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	PMID:12488434^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857204	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008286	insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006898	receptor-mediated endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:16513830^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24078630^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14562105^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
colocalizes_with	GO:0005635	nuclear envelope	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2917	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0060267	positive regulation of respiratory burst	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0051425	PTB domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0048639	positive regulation of developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0045995	regulation of embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0031995	insulin-like growth factor II binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
part_of	GO:0031981	nuclear lumen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
involved_in	GO:0019087	transformation of host cell by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P06213 ensembl:ENSP00000303830	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	C		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Pitetti, JL et al. (2013) Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 9 e1003160 PubMed GONUTS page
↑ Liang, L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151 741-7 PubMed GONUTS page
↑ Ribon, V et al. (1998) A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol. Cell. Biol. 18 872-9 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Giovannone, B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum. Mol. Genet. 18 4629-39 PubMed GONUTS page
↑ ^6.0 ^6.1 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Martineau, LC et al. (1999) Age-associated alterations in cardiac and skeletal muscle glucose transporters, insulin and IGF-1 receptors, and PI3-kinase protein contents in the C57BL/6 mouse. Mech. Ageing Dev. 106 217-32 PubMed GONUTS page
↑ ^9.0 ^9.1 Kido, Y et al. (2002) Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance. J. Biol. Chem. 277 36740-7 PubMed GONUTS page
↑ Nef, S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426 291-5 PubMed GONUTS page
↑ Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page
↑ Lu, X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147 3123-32 PubMed GONUTS page
↑ Tseng, LT et al. (2013) LMBD1 protein serves as a specific adaptor for insulin receptor internalization. J. Biol. Chem. 288 32424-32 PubMed GONUTS page
↑ Bogan, JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425 727-33 PubMed GONUTS page

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[PMID:20032056-2] Liang, L et al. (2010) Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology 151 741-7 PubMed GONUTS page

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[PMID:19744960-5] Giovannone, B et al. (2009) GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum. Mol. Genet. 18 4629-39 PubMed GONUTS page

[PMID:23906066-6] 6.0 ^6.1 Günschmann, C et al. (2013) Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev. Cell 26 176-87 PubMed GONUTS page

[PMID:23382219-7] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

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[PMID:14628051-10] Nef, S et al. (2003) Testis determination requires insulin receptor family function in mice. Nature 426 291-5 PubMed GONUTS page

[PMID:12488434-11] Kitamura, T et al. (2002) The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 110 1839-47 PubMed GONUTS page

[PMID:16513830-12] Lu, X et al. (2006) DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology 147 3123-32 PubMed GONUTS page

[PMID:24078630-13] Tseng, LT et al. (2013) LMBD1 protein serves as a specific adaptor for insulin receptor internalization. J. Biol. Chem. 288 32424-32 PubMed GONUTS page

[PMID:14562105-14] Bogan, JS et al. (2003) Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature 425 727-33 PubMed GONUTS page

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