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MOUSE:IFI4

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ifi204
Protein Name(s) Interferon-activable protein 204

Ifi-204 Interferon-inducible protein p204

External Links
UniProt P0DOV2
EMBL M31419
AK150522
CT010351
BC010546
CCDS CCDS35792.1
PIR B34457
RefSeq NP_032355.2
UniGene Mm.261270
SMR P0DOV2
iPTMnet P0DOV2
PhosphoSitePlus P0DOV2
MaxQB P0DOV2
Ensembl ENSMUST00000111214
GeneID 15951
KEGG mmu:15951
CTD 15951
MGI MGI:96429
eggNOG ENOG410J5NP
ENOG410Y78B
GeneTree ENSGT00390000013296
HOGENOM HOG000033871
HOVERGEN HBG006122
KO K20914
OMA RKKNQMS
ChiTaRS Ifi204
PRO PR:P0DOV2
Proteomes UP000000589
CleanEx MM_IFI204
ExpressionAtlas P0DOV2
GO GO:0005829
GO:0016020
GO:0042405
GO:0016607
GO:0005730
GO:0005654
GO:0005634
GO:0001047
GO:0003690
GO:0042802
GO:0003723
GO:0000978
GO:0003712
GO:0008134
GO:0001078
GO:0035457
GO:0035458
GO:0048839
GO:0042771
GO:0045669
GO:0006357
GO:0006351
InterPro IPR004020
IPR004021
Pfam PF02760
PF02758
SMART SM01289
PROSITE PS50824
PS50834

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0042405

nuclear inclusion body

PMID:12513910[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035457

cellular response to interferon-alpha

PMID:12513910[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:12513910[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048839

inner ear development

PMID:21795542[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045669

positive regulation of osteoblast differentiation

PMID:15557274[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88177

P

Seeded From UniProt

complete

GO:0043032

positive regulation of macrophage activation

PMID:16244109[4]

ECO:0000314

P

Figure 6C: Analysis of RT-PCR showed that enforced expression of Ifi204 favors M-CSF-dependent macrophage differentiation in in FD-Fms cells.

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:14654789[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035458

cellular response to interferon-beta

PMID:19158679[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

PMID:19158679[6]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009617

response to bacterium

PMID:23012479[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006357

regulation of transcription by RNA polymerase II

PMID:15557274[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

colocalizes_with

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:14654789[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:14654789[5]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19158679[6]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

C

Seeded From UniProt

complete

enables

GO:0003712

transcription coregulator activity

PMID:15557274[3]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88177

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

PMID:19158679[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003690

double-stranded DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

F

Seeded From UniProt

complete

enables

GO:0001227

DNA-binding transcription repressor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q16666

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001227

P

Seeded From UniProt

complete

involved_in

GO:0002218

activation of innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040205

P

Seeded From UniProt

complete

involved_in

GO:0035458

cellular response to interferon-beta

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040205

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 De Andrea, M et al. (2002) The mouse interferon-inducible gene Ifi204 product interacts with the Tpr protein, a component of the nuclear pore complex. J. Interferon Cytokine Res. 22 1113-21 PubMed GONUTS page
  2. ↑ Lu, CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J. Neurosci. 31 10903-18 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Liu, CJ et al. (2005) The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation. J. Biol. Chem. 280 2788-96 PubMed GONUTS page
  4. ↑ Dauffy, J et al. (2006) The interferon-inducible gene, Ifi204, is transcriptionally activated in response to M-CSF, and its expression favors macrophage differentiation in myeloid progenitor cells. J. Leukoc. Biol. 79 173-83 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Aglipay, JA et al. (2003) A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene 22 8931-8 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
  7. ↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page
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