MOUSE:HTRA2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Htra2 (synonyms: Omi, Prss25)
Protein Name(s)	Serine protease HTRA2, mitochondrial High temperature requirement protein A2 HtrA2 Omi stress-regulated endoprotease Serine protease 25 Serine proteinase OMI
External Links
UniProt	Q9JIY5
EMBL	AF164513 AF175324
CCDS	CCDS20267.1
RefSeq	NP_062726.3
UniGene	Mm.21880
ProteinModelPortal	Q9JIY5
SMR	Q9JIY5
BioGrid	211100
DIP	DIP-41272N
IntAct	Q9JIY5
MINT	MINT-219738
MEROPS	S01.278
PhosphoSite	Q9JIY5
REPRODUCTION-2DPAGE	Q9JIY5
MaxQB	Q9JIY5
PaxDb	Q9JIY5
PRIDE	Q9JIY5
Ensembl	ENSMUST00000089645
GeneID	64704
KEGG	mmu:64704
UCSC	uc009clu.3
CTD	27429
MGI	MGI:1928676
eggNOG	COG0265
GeneTree	ENSGT00510000046315
HOGENOM	HOG000223641
HOVERGEN	HBG052044
InParanoid	Q9JIY5
KO	K08669
OMA	CLTSGTP
PhylomeDB	Q9JIY5
TreeFam	TF323480
BRENDA	3.4.21.108
NextBio	320171
PRO	PR:Q9JIY5
Proteomes	UP000000589
Bgee	Q9JIY5
CleanEx	MM_HTRA2
ExpressionAtlas	Q9JIY5
Genevestigator	Q9JIY5
GO	GO:0035631 GO:0000785 GO:0009898 GO:0005856 GO:0005829 GO:0005758 GO:0031966 GO:0005739 GO:0005634 GO:0004252 GO:0008344 GO:0007628 GO:0071363 GO:0034605 GO:0006672 GO:0030900 GO:0097193 GO:0008630 GO:0007005 GO:0060548 GO:0048666 GO:0019742 GO:0043065 GO:2001269 GO:2001241 GO:0040014 GO:0009635
Gene3D	2.30.42.10
InterPro	IPR001478 IPR001940 IPR009003
Pfam	PF13180
PRINTS	PR00834
SMART	SM00228
SUPFAM	SSF50156 SSF50494
PROSITE	PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005515	protein binding	PMID:20614026^[1]	ECO:0000021		UniProtKB:P27512	F		Figures 1 & 2 show co-immunoprecipitation using Western blot verification of mass spectrometry results of hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
	GO:0009898	internal side of plasma membrane	PMID:20614026^[1]	ECO:0000314			C		Figure 2. Western blot verification of mass spectrometry results. hmCD40 and hmCD40D67 ARC ‘‘activated receptor capture’’ samples.	complete
involved_in	GO:1904924	negative regulation of mitophagy in response to mitochondrial depolarization	PMID:24709290^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:24709290^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:24709290^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q8VCM5) part_of:(GO:0034599)\|has_direct_input(UniProtKB:Q8VCM5) part_of:(GO:1904924)	Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:24709290^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q8VCM5) part_of:(GO:0034599)\|has_direct_input(UniProtKB:Q8VCM5) part_of:(GO:1904924)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11602612^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:20614026^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11604410^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P98170)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
part_of	GO:1905370	serine-type endopeptidase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097193	intrinsic apoptotic signaling pathway	PMID:15509788^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512633	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070207	protein homotrimerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308906	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	PMID:8325640^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856960	P	occurs_in:(EMAPA:17577) results_in_development_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044257	cellular protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308906	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040014	regulation of multicellular organism growth	PMID:8325640^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040014	regulation of multicellular organism growth	PMID:15509788^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512633	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035458	cellular response to interferon-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15509788^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512633	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:15509788^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512633	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	F		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308906	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:8325640^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856960	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:15574596^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512633	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308906	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:15044455^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308906	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O43464	C		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
involved_in	GO:0019742	pentacyclic triterpenoid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
involved_in	GO:0009635	response to herbicide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
involved_in	GO:0006672	ceramide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B0BNB9 ensembl:ENSRNOP00000030076	C		Seeded From UniProt	complete
involved_in	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
part_of	GO:1905370	serine-type endopeptidase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0044257	cellular protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	F		Seeded From UniProt	complete
involved_in	GO:0035458	cellular response to interferon-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0010822	positive regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O43464 ensembl:ENSP00000258080	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001940	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001940	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0169	C		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Cilenti, L et al. (2014) Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. Biochim. Biophys. Acta 1843 1295-307 PubMed GONUTS page
↑ Martins, LM et al. (2002) The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277 439-44 PubMed GONUTS page
↑ Verhagen, AM et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 445-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Martins, LM et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24 9848-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Jones, JM et al. (1993) mnd2: a new mouse model of inherited motor neuron disease. Genomics 16 669-77 PubMed GONUTS page
↑ Dannenberg, JH et al. (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 18 2952-62 PubMed GONUTS page
↑ Guo, Y et al. (2004) Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. J. Biol. Chem. 279 24813-25 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:20614026-1] 1.0 ^1.1 ^1.2 ^1.3 Hostager, BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS ONE 5 e11380 PubMed GONUTS page

[PMID:24709290-2] 2.0 ^2.1 ^2.2 ^2.3 Cilenti, L et al. (2014) Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. Biochim. Biophys. Acta 1843 1295-307 PubMed GONUTS page

[PMID:11602612-3] Martins, LM et al. (2002) The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277 439-44 PubMed GONUTS page

[PMID:11604410-4] Verhagen, AM et al. (2002) HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 445-54 PubMed GONUTS page

[PMID:15509788-5] 5.0 ^5.1 ^5.2 ^5.3 Martins, LM et al. (2004) Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24 9848-62 PubMed GONUTS page

[PMID:8325640-6] 6.0 ^6.1 ^6.2 Jones, JM et al. (1993) mnd2: a new mouse model of inherited motor neuron disease. Genomics 16 669-77 PubMed GONUTS page

[PMID:15574596-7] Dannenberg, JH et al. (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 18 2952-62 PubMed GONUTS page

[PMID:15044455-8] Guo, Y et al. (2004) Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. J. Biol. Chem. 279 24813-25 PubMed GONUTS page

[PMID:18614015-9] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-10] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

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MOUSE:HTRA2

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