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PMID:15574596
| Citation |
Dannenberg, JH, Schuijff, L, Dekker, M, van der Valk, M and te Riele, H (2004) Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev. 18:2952-62 |
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| Abstract |
The retinoblastoma gene family consists of three genes: RB, p107, and p130. While loss of pRB causes retinoblastoma in humans and pituitary gland tumors in mice, tumorigenesis in other tissues may be suppressed by p107 and p130. To test this hypothesis, we have generated chimeric mice from embryonic stem cells carrying compound loss-of-function mutations in the Rb gene family. We found that Rb/p107- and Rb/p130-deficient mice were highly cancer prone. We conclude that in a variety of tissues tumor development by loss of pRB is suppressed by its homologs p107 and p130. The redundancy of the retinoblastoma proteins in vivo is reflected by the behavior of Rb-family-defective mouse embryonic fibroblasts in vitro. |
| Links |
PubMed PMC534655 Online version:10.1101/gad.322004 |
| Keywords |
Animals; Blotting, Southern; Chimera; Mice; Nuclear Proteins/genetics; Nuclear Proteins/physiology; Polymerase Chain Reaction; Proteins/genetics; Proteins/physiology; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130 |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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