MOUSE:HSF1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hsf1 (ECO:0000312 with MGI:MGI:96238)
Protein Name(s)	Heat shock factor protein 1 (ECO:0000250 with UniProtKB:Q00613) HSF 1 Heat shock transcription factor 1 (ECO:0000250 with UniProtKB:Q00613) HSTF 1
External Links
UniProt	P38532
EMBL	X61753 BC013716 AF059275
CCDS	CCDS27572.1
PIR	A40583
RefSeq	NP_001318083.1 NP_032322.1
UniGene	Mm.347444
ProteinModelPortal	P38532
SMR	P38532
BioGrid	200443
IntAct	P38532
STRING	10090.ENSMUSP00000072617
BindingDB	P38532
ChEMBL	CHEMBL5313
iPTMnet	P38532
PhosphoSitePlus	P38532
MaxQB	P38532
PaxDb	P38532
PeptideAtlas	P38532
PRIDE	P38532
Ensembl	ENSMUST00000072838
GeneID	15499
KEGG	mmu:15499
UCSC	uc056yzg.1
CTD	3297
MGI	MGI:96238
eggNOG	KOG0627 COG5169
GeneTree	ENSGT00390000001182
HOGENOM	HOG000253917
HOVERGEN	HBG005999
InParanoid	P38532
KO	K09414
OMA	QFSLEHV
PhylomeDB	P38532
TreeFam	TF330401
Reactome	R-MMU-3371453 R-MMU-3371511 R-MMU-3371568 R-MMU-3371571
PRO	PR:P38532
Proteomes	UP000000589
Bgee	ENSMUSG00000022556
CleanEx	MM_HSF1
ExpressionAtlas	P38532
Genevisible	P38532
GO	GO:0005813 GO:0000777 GO:0005737 GO:0005829 GO:0000791 GO:0000792 GO:0000776 GO:0097431 GO:0097165 GO:0005654 GO:0005634 GO:0048471 GO:0016605 GO:0045120 GO:0043234 GO:1990904 GO:0003682 GO:0031490 GO:0003677 GO:0031072 GO:0051879 GO:0042802 GO:1990841 GO:0046982 GO:0019901 GO:0043621 GO:0000979 GO:0001162 GO:0000978 GO:0043565 GO:0098847 GO:0097677 GO:0001078 GO:0061770 GO:0043623 GO:1904385 GO:0071276 GO:0071280 GO:0072738 GO:0071392 GO:0071480 GO:0034605 GO:0070301 GO:1904845 GO:0071222 GO:1904843 GO:0035865 GO:1903936 GO:0034620 GO:0006952 GO:0006281 GO:0001892 GO:0060136 GO:0007143 GO:0001701 GO:0000165 GO:0006397 GO:0009299 GO:0051028 GO:0010667 GO:0008285 GO:2001033 GO:0090084 GO:1901215 GO:0000122 GO:0032720 GO:1902512 GO:0008284 GO:0043280 GO:0090261 GO:1904528 GO:0045931 GO:1900365 GO:0040018 GO:0045944 GO:0061408 GO:0042531 GO:0051260 GO:0070207 GO:0006468 GO:1900034 GO:0043497 GO:0014823 GO:0009408 GO:1990910 GO:0032496 GO:0007584 GO:1990911 GO:0033574 GO:0007283
Gene3D	1.10.10.10
InterPro	IPR000232 IPR027725 IPR010542 IPR036388 IPR036390
PANTHER	PTHR10015
Pfam	PF00447 PF06546
PRINTS	PR00056
SMART	SM00415
SUPFAM	SSF46785
PROSITE	PS00434

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:26251235^[1]	ECO:0000315			P		Figure 4 shows a significant decrease in mRNA production in the HSF1KO-HD in mice relative to the control group. This indicates that HSF1 is a positive regulator of gene expression in Nfatc2, Pdzk3, and Cryab in heart, spleen and straitium tissues.	complete CACAO 13054
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26344102^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0097165	nuclear stress granule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
enables	GO:0061770	translation elongation factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
involved_in	GO:1900365	positive regulation of mRNA polyadenylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
involved_in	GO:1903936	cellular response to sodium arsenite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0072738	cellular response to diamide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
involved_in	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000001154 UniProtKB:Q00613	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001222 MGI:MGI:1347058 MGI:MGI:3045337 MGI:MGI:96238 MGI:MGI:96239 PANTHER:PTN000001154 RGD:1310808 SGD:S000005666 UniProtKB:P38529 UniProtKB:P38531 UniProtKB:Q00613 ZFIN:ZDB-GENE-000616-16 ZFIN:ZDB-GENE-011128-1 ZFIN:ZDB-GENE-050306-18	F		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3045337 PANTHER:PTN000001154 RGD:620913 UniProtKB:O80982 UniProtKB:P38529 UniProtKB:P38531 UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000195882 FB:FBgn0001222 MGI:MGI:3045337 MGI:MGI:96238 MGI:MGI:96239 PANTHER:PTN000001154 PomBase:SPAC2E12.02 PomBase:SPAC8C9.14 RGD:1310808 RGD:620913 SGD:S000001249 SGD:S000003041 SGD:S000005666 TAIR:locus:2005495 TAIR:locus:2075447 TAIR:locus:2117139 TAIR:locus:2144603 TAIR:locus:2149050 UniProtKB:I1LGH5 UniProtKB:I1MPZ9 UniProtKB:K7LH36 UniProtKB:O80982 UniProtKB:P38529 UniProtKB:P38530 UniProtKB:P38531 UniProtKB:Q00613 UniProtKB:Q43457 UniProtKB:Q5A287 UniProtKB:Q942D6 UniProtKB:Q9UBD0 WB:WBGene00002004	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000195882 FB:FBgn0001222 PANTHER:PTN000001154 SGD:S000001249 SGD:S000003041 TAIR:locus:2149050	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96238 MGI:MGI:96239 PANTHER:PTN000001154 PomBase:SPAC2E12.02 PomBase:SPAC8C9.14 SGD:S000005666 UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904528	positive regulation of microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904385	cellular response to angiotensin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903936	cellular response to sodium arsenite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902512	positive regulation of apoptotic DNA fragmentation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900365	positive regulation of mRNA polyadenylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900034	regulation of cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
enables	GO:0098847	sequence-specific single stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	F		Seeded From UniProt	complete
enables	GO:0097677	STAT family protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	F		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0097165	nuclear stress granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090261	positive regulation of inclusion body assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090084	negative regulation of inclusion body assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072738	cellular response to diamide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071478	cellular response to radiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071280	cellular response to copper ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071276	cellular response to cadmium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070207	protein homotrimerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
enables	GO:0061770	translation elongation factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060136	embryonic process involved in female pregnancy	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P	has_participant:(EMAPA:16042)\|has_participant:(EMAPA:35689)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
part_of	GO:0045120	pronucleus	PMID:14766729^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000365)	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:18755693^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17838)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040018	positive regulation of multicellular organism growth	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034620	cellular response to unfolded protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033574	response to testosterone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17785525^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01853 UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P	regulates_o_occurs_in:(EMAPA:35690)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032355	response to estradiol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P	has_participant:(EMAPA:16105)\|has_participant:(EMAPA:16894)\|has_participant:(EMAPA:16846)\|has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009299	mRNA transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:15483628^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347058	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:14994269^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96239	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007143	female meiotic nuclear division	PMID:21690297^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P	occurs_in:(CL:0000023)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006952	defense response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:18755693^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14766729^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000365)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11032181^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18434628^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11032181^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21690297^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000023)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11032181^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001892	embryonic placenta development	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P	results_in_development_of:(EMAPA:16042)\|results_in_development_of:(EMAPA:35689)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:10545106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155444	P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18434628^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	C		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620913	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q00613	P		Seeded From UniProt	complete
involved_in	GO:1990911	response to psychosocial stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1990910	response to hypobaric hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	F		Seeded From UniProt	complete
involved_in	GO:1904845	cellular response to L-glutamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1904843	cellular response to nitroglycerin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1904528	positive regulation of microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1902512	positive regulation of apoptotic DNA fragmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1901652	response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
enables	GO:0098847	sequence-specific single stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	F		Seeded From UniProt	complete
enables	GO:0097677	STAT family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	F		Seeded From UniProt	complete
involved_in	GO:0090261	positive regulation of inclusion body assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0090084	negative regulation of inclusion body assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0071478	cellular response to radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0071230	cellular response to amino acid stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0035865	cellular response to potassium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	F		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	C		Seeded From UniProt	complete
part_of	GO:0000791	euchromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAF1 ensembl:ENSRNOP00000047030	C		Seeded From UniProt	complete
involved_in	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:1903936	cellular response to sodium arsenite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:1900365	positive regulation of mRNA polyadenylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
part_of	GO:0097431	mitotic spindle pole	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
part_of	GO:0097165	nuclear stress granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
involved_in	GO:0072738	cellular response to diamide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0061770	translation elongation factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:0061408	positive regulation of transcription from RNA polymerase II promoter in response to heat stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
involved_in	GO:0034622	cellular protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
involved_in	GO:0009299	mRNA transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00613 ensembl:ENSP00000431512	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010542	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000232 InterPro:IPR010542	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000232	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000232 InterPro:IPR010542	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000232	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0995	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C		Seeded From UniProt	complete
part_of	GO:0000775	chromosome, centromeric region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0137	C		Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0448	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
part_of	GO:0000777	condensed chromosome kinetochore	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0149	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hayashida, N (2015) Non-Hsp genes are essential for HSF1-mediated maintenance of whole body homeostasis. Exp. Anim. 64 397-406 PubMed GONUTS page
↑ Ma, X et al. (2015) Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis. Cell Metab. 22 695-708 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Xiao, X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 18 5943-52 PubMed GONUTS page
↑ ^5.0 ^5.1 Fiorenza, MT et al. (2004) Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol. Reprod. 70 1606-13 PubMed GONUTS page
↑ ^6.0 ^6.1 Fujimoto, M et al. (2008) Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J. Biol. Chem. 283 29961-70 PubMed GONUTS page
↑ Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page
↑ Fujimoto, M et al. (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 23 4297-306 PubMed GONUTS page
↑ Wang, G et al. (2004) Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis 38 66-80 PubMed GONUTS page
↑ ^10.0 ^10.1 Le Masson, F et al. (2011) Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Mol. Cell. Biol. 31 3410-23 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Eriksson, M et al. (2000) Heat shock factor 2 is activated during mouse heart development. Int. J. Dev. Biol. 44 471-7 PubMed GONUTS page
↑ ^12.0 ^12.1 Wilkerson, DC et al. (2008) Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol. Reprod. 79 283-8 PubMed GONUTS page

[PMID:26251235-1] Hayashida, N (2015) Non-Hsp genes are essential for HSF1-mediated maintenance of whole body homeostasis. Exp. Anim. 64 397-406 PubMed GONUTS page

[PMID:26344102-2] Ma, X et al. (2015) Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis. Cell Metab. 22 695-708 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10545106-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Xiao, X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J. 18 5943-52 PubMed GONUTS page

[PMID:14766729-5] 5.0 ^5.1 Fiorenza, MT et al. (2004) Early transcriptional activation of the hsp70.1 gene by osmotic stress in one-cell embryos of the mouse. Biol. Reprod. 70 1606-13 PubMed GONUTS page

[PMID:18755693-6] 6.0 ^6.1 Fujimoto, M et al. (2008) Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. J. Biol. Chem. 283 29961-70 PubMed GONUTS page

[PMID:17785525-7] Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page

[PMID:15483628-8] Fujimoto, M et al. (2004) HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 23 4297-306 PubMed GONUTS page

[PMID:14994269-9] Wang, G et al. (2004) Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility. Genesis 38 66-80 PubMed GONUTS page

[PMID:21690297-10] 10.0 ^10.1 Le Masson, F et al. (2011) Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis. Mol. Cell. Biol. 31 3410-23 PubMed GONUTS page

[PMID:11032181-11] 11.0 ^11.1 ^11.2 Eriksson, M et al. (2000) Heat shock factor 2 is activated during mouse heart development. Int. J. Dev. Biol. 44 471-7 PubMed GONUTS page

[PMID:18434628-12] 12.0 ^12.1 Wilkerson, DC et al. (2008) Interaction of HSF1 and HSF2 with the Hspa1b promoter in mouse epididymal spermatozoa. Biol. Reprod. 79 283-8 PubMed GONUTS page

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