MOUSE:HDAC5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hdac5
Protein Name(s)	Histone deacetylase 5 HD5 Histone deacetylase mHDA1
External Links
UniProt	Q9Z2V6
EMBL	AF006602 AF207748
UniGene	Mm.22665
ProteinModelPortal	Q9Z2V6
SMR	Q9Z2V6
DIP	DIP-40855N
IntAct	Q9Z2V6
MINT	MINT-125422
STRING	10090.ENSMUSP00000102770
BindingDB	Q9Z2V6
ChEMBL	CHEMBL2768
PhosphoSite	Q9Z2V6
MaxQB	Q9Z2V6
PaxDb	Q9Z2V6
PRIDE	Q9Z2V6
MGI	MGI:1333784
eggNOG	KOG1343 COG0123
HOVERGEN	HBG057100
InParanoid	Q9Z2V6
ChiTaRS	Hdac5
PRO	PR:Q9Z2V6
Proteomes	UP000000589
CleanEx	MM_HDAC5
GO	GO:0005737 GO:0005829 GO:0005794 GO:0000118 GO:0016604 GO:0000790 GO:0005654 GO:0005634 GO:0090571 GO:0001047 GO:0001046 GO:0004407 GO:0042826 GO:0046872 GO:0032041 GO:0033558 GO:0019901 GO:0005080 GO:0070491 GO:0001226 GO:0001085 GO:0001025 GO:0003714 GO:0008134 GO:0001077 GO:0042113 GO:0030183 GO:0071498 GO:0016568 GO:0007507 GO:0016575 GO:0006954 GO:0033555 GO:0090051 GO:0010629 GO:0010832 GO:0045668 GO:0045843 GO:0000122 GO:0045892 GO:0007399 GO:0002076 GO:2000179 GO:0051091 GO:2000648 GO:0045944 GO:0006476 GO:0040029 GO:0010830 GO:0043393 GO:0048742 GO:0051153 GO:0061333 GO:0042220 GO:0006366
Gene3D	3.40.800.20
InterPro	IPR000286 IPR023801 IPR024643 IPR017320 IPR030703
PANTHER	PTHR10625 PTHR10625:SF57
Pfam	PF12203 PF00850
PIRSF	PIRSF037911
PRINTS	PR01270

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0001226	RNA polymerase II transcription corepressor binding	PMID:12007404^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9JJY4	F		Seeded From UniProt	complete
part_of	GO:0090571	RNA polymerase II transcription repressor complex	PMID:12007404^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:12007404^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000581)	Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:20123967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0044295	axonal growth cone	PMID:26157139^[3]	ECO:0000314			C		Figure 5A	complete CACAO 11098
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:20123967^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11081517^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11081517^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:20123967^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q64104	F		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:20181743^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061333	renal tubule morphogenesis	PMID:20181743^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20181743^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17468767^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60670	F		Seeded From UniProt	complete
involved_in	GO:0010830	regulation of myotube differentiation	PMID:17468767^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10748098^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02078	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17468767^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17468767^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20181743^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20181743^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20181743^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051153	regulation of striated muscle cell differentiation	PMID:17786239^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1931221 MGI:MGI:3036234	P	occurs_in:(EMAPA:32716) regulates_o_results_in_acquisition_of_features_of:(CL:0000189)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048742	regulation of skeletal muscle fiber development	PMID:17786239^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1931221 MGI:MGI:3036234	P	occurs_in:(EMAPA:32716) occurs_in:(CL:0000189)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16260608^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:15990875^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	PMID:17988634^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056065	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	PMID:17988634^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033555	multicellular organismal response to stress	PMID:17988634^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3056065	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	C		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:11641275^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010832	negative regulation of myotube differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:23926128^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15367668^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1931221	P	results_in_development_of:(EMAPA:17333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18332106^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18198354^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11081517^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18198354^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11081517^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:15990875^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1201674	F	has_regulation_target:(MGI:MGI:88156)	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:10640276^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619980	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:15990875^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(CL:0000062)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17940050^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137495 MGI:MGI:97275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15990875^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98725	P	has_regulation_target:(MGI:MGI:88156)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15601857^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2137495	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23926128^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10640276^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UQL6	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017320	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017320 InterPro:IPR030703	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030703	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030703	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017320	P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017320 InterPro:IPR030703	P		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030703	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045843	negative regulation of striated muscle tissue development	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042113	B cell activation	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:12711221^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Klappacher, GW et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109 169-80 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Sun, G et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30 1997-2005 PubMed GONUTS page
↑ Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Berdeaux, R et al. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13 597-603 PubMed GONUTS page
↑ Lemercier, C et al. (2000) mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275 15594-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Potthoff, MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117 2459-67 PubMed GONUTS page
↑ Dai, YS et al. (2005) The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol. Cell. Biol. 25 9936-48 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Kang, JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 24 2543-55 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Renthal, W et al. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56 517-29 PubMed GONUTS page
↑ Potter, GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 15 2687-701 PubMed GONUTS page
↑ ^13.0 ^13.1 Fu, X et al. (2013) AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am. J. Physiol., Cell Physiol. 305 C887-95 PubMed GONUTS page
↑ Chang, S et al. (2004) Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol. Cell. Biol. 24 8467-76 PubMed GONUTS page
↑ Backs, J et al. (2008) Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol. Cell. Biol. 28 3437-45 PubMed GONUTS page
↑ ^16.0 ^16.1 Mukwevho, E et al. (2008) Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Am. J. Physiol. Endocrinol. Metab. 294 E582-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Kao, HY et al. (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 14 55-66 PubMed GONUTS page
↑ Long, X et al. (2007) Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc. Natl. Acad. Sci. U.S.A. 104 16570-5 PubMed GONUTS page
↑ Cao, D et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol. Cell. Biol. 25 364-76 PubMed GONUTS page
↑ ^20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

[PMID:12007404-1] 1.0 ^1.1 ^1.2 Klappacher, GW et al. (2002) An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell 109 169-80 PubMed GONUTS page

[PMID:20123967-2] 2.0 ^2.1 ^2.2 Sun, G et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30 1997-2005 PubMed GONUTS page

[PMID:26157139-3] Cho, Y et al. (2015) Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J. Biol. Chem. 290 22759-70 PubMed GONUTS page

[PMID:11081517-4] 4.0 ^4.1 ^4.2 ^4.3 McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page

[PMID:20181743-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page

[PMID:17468767-6] 6.0 ^6.1 ^6.2 ^6.3 Berdeaux, R et al. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat. Med. 13 597-603 PubMed GONUTS page

[PMID:10748098-7] Lemercier, C et al. (2000) mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J. Biol. Chem. 275 15594-9 PubMed GONUTS page

[PMID:17786239-8] 8.0 ^8.1 Potthoff, MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117 2459-67 PubMed GONUTS page

[PMID:16260608-9] Dai, YS et al. (2005) The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol. Cell. Biol. 25 9936-48 PubMed GONUTS page

[PMID:15990875-10] 10.0 ^10.1 ^10.2 ^10.3 Kang, JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 24 2543-55 PubMed GONUTS page

[PMID:17988634-11] 11.0 ^11.1 ^11.2 Renthal, W et al. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56 517-29 PubMed GONUTS page

[PMID:11641275-12] Potter, GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev. 15 2687-701 PubMed GONUTS page

[PMID:23926128-13] 13.0 ^13.1 Fu, X et al. (2013) AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am. J. Physiol., Cell Physiol. 305 C887-95 PubMed GONUTS page

[PMID:15367668-14] Chang, S et al. (2004) Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol. Cell. Biol. 24 8467-76 PubMed GONUTS page

[PMID:18332106-15] Backs, J et al. (2008) Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol. Cell. Biol. 28 3437-45 PubMed GONUTS page

[PMID:18198354-16] 16.0 ^16.1 Mukwevho, E et al. (2008) Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism. Am. J. Physiol. Endocrinol. Metab. 294 E582-8 PubMed GONUTS page

[PMID:10640276-17] 17.0 ^17.1 Kao, HY et al. (2000) Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression. Genes Dev. 14 55-66 PubMed GONUTS page

[PMID:17940050-18] Long, X et al. (2007) Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc. Natl. Acad. Sci. U.S.A. 104 16570-5 PubMed GONUTS page

[PMID:15601857-19] Cao, D et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol. Cell. Biol. 25 364-76 PubMed GONUTS page

[PMID:12711221-20] 20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

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MOUSE:HDAC5

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