MOUSE:HAND2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hand2 (synonyms: Dhand, Hed, Thing2)
Protein Name(s)	Heart- and neural crest derivatives-expressed protein 2 Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 dHAND Helix-loop-helix transcription factor expressed in embryo and deciduum Thing-2
External Links
UniProt	Q61039
EMBL	U40039 AK035160 U43715
CCDS	CCDS22315.1
RefSeq	NP_034532.3
UniGene	Mm.430844
ProteinModelPortal	Q61039
SMR	Q61039
BioGrid	200205
IntAct	Q61039
MINT	MINT-1666727
PhosphoSite	Q61039
MaxQB	Q61039
PRIDE	Q61039
Ensembl	ENSMUST00000040104
GeneID	15111
KEGG	mmu:15111
UCSC	uc009lss.2
CTD	9464
MGI	MGI:103580
eggNOG	NOG259520
GeneTree	ENSGT00760000119097
HOGENOM	HOG000232082
HOVERGEN	HBG051880
InParanoid	Q61039
KO	K18486
OMA	ATRCGHE
OrthoDB	EOG7G1V82
PhylomeDB	Q61039
TreeFam	TF315153
ChiTaRS	Hand2
NextBio	287514
PRO	PR:Q61039
Proteomes	UP000000589
Bgee	Q61039
Genevestigator	Q61039
GO	GO:0000790 GO:0005634 GO:0005667 GO:0033613 GO:0003680 GO:0070888 GO:0046982 GO:0042803 GO:0001077 GO:0000977 GO:0043565 GO:0003713 GO:0008134 GO:0007512 GO:0001525 GO:0003278 GO:0061309 GO:0003253 GO:0003219 GO:0060536 GO:0061325 GO:0060982 GO:0061371 GO:0042733 GO:0007507 GO:0001947 GO:0003007 GO:0001701 GO:0010463 GO:0060485 GO:0043066 GO:0010667 GO:0043392 GO:0045668 GO:0043433 GO:0014032 GO:0042475 GO:0060021 GO:0048935 GO:2000764 GO:0045944 GO:2000763 GO:2000679 GO:0045893 GO:0003266 GO:0006355 GO:0001967 GO:0048485 GO:0048538 GO:0043586 GO:0061032
Gene3D	4.10.280.10
InterPro	IPR011598
Pfam	PF00010
SMART	SM00353
SUPFAM	SSF47459
PROSITE	PS50888

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060021	palate development	PMID:19341725^[1]	ECO:0000315			P		Figure 1,4	complete
	GO:0008219	cell death	PMID:19341725^[1]	ECO:0000315			P		Fig. 6A,B Fig. 7G–I	complete
	GO:0045941	positive regulation of transcription	PMID:19341725^[1]	ECO:0000315			P		Figure 5A, 5B	complete
	GO:0008283	cell proliferation	PMID:19341725^[1]	ECO:0000315			P		Figure 6C–E	complete
involved_in	GO:2000764	positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000763	positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0070888	E-box binding	PMID:11812799^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11812799^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11812799^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:11812799^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11812799^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61039	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61295	F		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11812799^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15806-1	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:11812799^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61295	F		Seeded From UniProt	complete
involved_in	GO:0003266	regulation of secondary heart field cardioblast proliferation	PMID:19008477^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003219	cardiac right ventricle formation	PMID:11076755^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014032	neural crest cell development	PMID:9671575^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P	occurs_in:(EMAPA:16387)\|occurs_in:(EMAPA:16393)\|occurs_in:(EMAPA:16281)\|occurs_in:(EMAPA:16404)\|occurs_in:(EMAPA:16772)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010463	mesenchymal cell proliferation	PMID:19341725^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P	occurs_in:(EMAPA:17936)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19144722^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q08775	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621207	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007512	adult heart development	PMID:9171826^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15576406^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103577	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:15351717^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19144722^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621207	C		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003278	apoptotic process involved in heart morphogenesis	PMID:11784028^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	PMID:20144608^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:3803647	P	occurs_in:(EMAPA:16346)\|occurs_in:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003007	heart morphogenesis	PMID:11784028^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001967	suckling behavior	PMID:17531968^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:9171826^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:9171826^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621207	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903929	primary palate development	PMID:17531968^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20144608^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061371	determination of heart left/right asymmetry	PMID:9576835^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857639	P	has_participant:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061325	cell proliferation involved in outflow tract morphogenesis	PMID:20144608^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:3803647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061032	visceral serous pericardium development	PMID:21350214^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149,MGI:MGI:3801682	P	results_in_development_of:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060982	coronary artery morphogenesis	PMID:21350214^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149,MGI:MGI:4838016	P	occurs_in:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060536	cartilage morphogenesis	PMID:17764670^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103577	P	has_participant:(EMAPA:18290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060485	mesenchyme development	PMID:17764670^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103577	P	results_in_development_of:(EMAPA:18290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:19341725^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P	results_in_development_of:(EMAPA:17930)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:17531968^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048935	peripheral nervous system neuron development	PMID:16145670^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048485	sympathetic nervous system development	PMID:16145670^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:12392994^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42582	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20144608^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98510	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12070084^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98510	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16145670^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:19144722^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2653307	P	regulates_o_occurs_in:(EMAPA:18290)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045668	negative regulation of osteoblast differentiation	PMID:19144722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043586	tongue development	PMID:17531968^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12070084^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98510	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:19144722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043392	negative regulation of DNA binding	PMID:19144722^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:19341725^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3715149	P	regulates_o_occurs_in:(EMAPA:17935) regulates_o_occurs_in:(CL:0000078)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:12070084^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:17764670^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103577	P	has_participant:(EMAPA:32889)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034103	regulation of tissue remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61296	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621207	F		Seeded From UniProt	complete
involved_in	GO:2000679	positive regulation of transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:0034103	regulation of tissue remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	C		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
involved_in	GO:0007512	adult heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	P		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61296 ensembl:ENSP00000352565	C		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9007813	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xiong, W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev. Biol. 330 131-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Morikawa, Y & Cserjesi, P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ. Res. 103 1422-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Dai, YS & Cserjesi, P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J. Biol. Chem. 277 12604-12 PubMed GONUTS page
↑ McFadden, DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127 5331-41 PubMed GONUTS page
↑ Thomas, T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125 3005-14 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Funato, N et al. (2009) Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136 615-25 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Srivastava, D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat. Genet. 16 154-60 PubMed GONUTS page
↑ McFadden, DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132 189-201 PubMed GONUTS page
↑ Murakami, M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem. Biophys. Res. Commun. 323 168-74 PubMed GONUTS page
↑ ^10.0 ^10.1 Yamagishi, H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev. Biol. 239 190-203 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Holler, KL et al. (2010) Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev. Biol. 341 291-304 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Morikawa, Y et al. (2007) Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev. Biol. 307 114-26 PubMed GONUTS page
↑ Thomas, T et al. (1998) The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev. Biol. 196 228-36 PubMed GONUTS page
↑ ^14.0 ^14.1 Barnes, RM et al. (2011) Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ. Res. 108 940-9 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Barbosa, AC et al. (2007) Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev. Biol. 310 154-68 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Morikawa, Y et al. (2005) The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev. Dyn. 234 613-21 PubMed GONUTS page
↑ Thattaliyath, BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J. Mol. Cell. Cardiol. 34 1335-44 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 McFadden, DG et al. (2002) Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development 129 3077-88 PubMed GONUTS page

[PMID:19341725-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Xiong, W et al. (2009) Hand2 is required in the epithelium for palatogenesis in mice. Dev. Biol. 330 131-41 PubMed GONUTS page

[PMID:19008477-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Morikawa, Y & Cserjesi, P (2008) Cardiac neural crest expression of Hand2 regulates outflow and second heart field development. Circ. Res. 103 1422-9 PubMed GONUTS page

[PMID:11812799-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Dai, YS & Cserjesi, P (2002) The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. J. Biol. Chem. 277 12604-12 PubMed GONUTS page

[PMID:11076755-4] McFadden, DG et al. (2000) A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. Development 127 5331-41 PubMed GONUTS page

[PMID:9671575-5] Thomas, T et al. (1998) A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development 125 3005-14 PubMed GONUTS page

[PMID:19144722-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Funato, N et al. (2009) Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development 136 615-25 PubMed GONUTS page

[PMID:9171826-7] 7.0 ^7.1 ^7.2 Srivastava, D et al. (1997) Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat. Genet. 16 154-60 PubMed GONUTS page

[PMID:15576406-8] McFadden, DG et al. (2005) The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132 189-201 PubMed GONUTS page

[PMID:15351717-9] Murakami, M et al. (2004) Differential cooperation between dHAND and three different E-proteins. Biochem. Biophys. Res. Commun. 323 168-74 PubMed GONUTS page

[PMID:11784028-10] 10.0 ^10.1 Yamagishi, H et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev. Biol. 239 190-203 PubMed GONUTS page

[PMID:20144608-11] 11.0 ^11.1 ^11.2 ^11.3 Holler, KL et al. (2010) Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev. Biol. 341 291-304 PubMed GONUTS page

[PMID:17531968-12] 12.0 ^12.1 ^12.2 ^12.3 Morikawa, Y et al. (2007) Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev. Biol. 307 114-26 PubMed GONUTS page

[PMID:9576835-13] Thomas, T et al. (1998) The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness. Dev. Biol. 196 228-36 PubMed GONUTS page

[PMID:21350214-14] 14.0 ^14.1 Barnes, RM et al. (2011) Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ. Res. 108 940-9 PubMed GONUTS page

[PMID:17764670-15] 15.0 ^15.1 ^15.2 Barbosa, AC et al. (2007) Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev. Biol. 310 154-68 PubMed GONUTS page

[PMID:16145670-16] 16.0 ^16.1 ^16.2 Morikawa, Y et al. (2005) The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev. Dyn. 234 613-21 PubMed GONUTS page

[PMID:12392994-17] Thattaliyath, BD et al. (2002) The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J. Mol. Cell. Cardiol. 34 1335-44 PubMed GONUTS page

[PMID:12070084-18] 18.0 ^18.1 ^18.2 McFadden, DG et al. (2002) Misexpression of dHAND induces ectopic digits in the developing limb bud in the absence of direct DNA binding. Development 129 3077-88 PubMed GONUTS page

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MOUSE:HAND2

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